Emerging Opportunity and Destiny of mcr-1- and tet(X4)-Coharboring Plasmids in Escherichia coli

Emerging Opportunity and Destiny of mcr-1- and tet(X4)-Coharboring Plasmids in Escherichia coli

ABSTRACT The emergence of the plasmid-mediated colistin resistance gene mcr-1 and the plasmid-mediated tigecycline resistance gene tet(X4) represents a significant threat to public health. Although mcr-1 and tet(X4) have been reported to coexist in the same isolate, there are no reports on the emerg...

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Bibliographic Details
Main Authors: Xiaoyu Lu, Xia Xiao, Yuan Liu, Ruichao Li, Zhiqiang Wang
Format: Article
Language:English
Published: American Society for Microbiology 2021-12-01
Series:Microbiology Spectrum
Subjects:
Escherichia coli
tet(X4)
mcr-1
fusion plasmids
plasmid evolution
fitness costs
Online Access:https://journals.asm.org/doi/10.1128/Spectrum.01520-21

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