Association between Uremic Toxin Concentrations and Bone Mineral Density after Kidney Transplantation
Although uremic osteoporosis is a component of mineral and bone disorder in chronic kidney disease, uremic toxin (UT) concentrations in patients with end-stage kidney disease and bone mineral density (BMD) changes after kidney transplantation have not previously been described. We hypothesized that...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-11-01
|
| Series: | Toxins |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6651/12/11/715 |
| _version_ | 1797547979107729408 |
|---|---|
| author | Benjamin Batteux Sandra Bodeau Camille André Anne-Sophie Hurtel-Lemaire Valérie Gras-Champel Isabelle Desailly-Henry Kamel Masmoudi Youssef Bennis Ziad A. Massy Saïd Kamel Gabriel Choukroun Sophie Liabeuf |
| author_facet | Benjamin Batteux Sandra Bodeau Camille André Anne-Sophie Hurtel-Lemaire Valérie Gras-Champel Isabelle Desailly-Henry Kamel Masmoudi Youssef Bennis Ziad A. Massy Saïd Kamel Gabriel Choukroun Sophie Liabeuf |
| author_sort | Benjamin Batteux |
| collection | DOAJ |
| description | Although uremic osteoporosis is a component of mineral and bone disorder in chronic kidney disease, uremic toxin (UT) concentrations in patients with end-stage kidney disease and bone mineral density (BMD) changes after kidney transplantation have not previously been described. We hypothesized that elevated UT concentrations at the time of transplantation could have a negative impact on bone during the early post-transplantation period. Hence, we sought to determine whether concentrations of UTs (trimethylamine-N-oxide, indoxylsulfate, p-cresylsulfate, p-cresylglucuronide, indole-3-acetic acid, hippuric acid, and 3-carboxy-4-methyl-5-propyl-furanpropionic acid) upon transplantation are predictive markers for (i) osteoporosis one month after transplantation, and (ii) a BMD decrease and the occurrence of fractures 12 and 24 months after kidney transplantation. Between 2012 and 2018, 310 kidney transplant recipients were included, and dual-energy X-ray absorptiometry was performed 1, 12, and 24 months after transplantation. The UT concentrations upon transplantation were determined by reverse-phase high-performance liquid chromatography. Indoxylsulfate concentrations upon transplantation were positively correlated with BMD one month after transplantation for the femoral neck but were not associated with osteoporosis status upon transplantation. Concentrations of the other UTs upon transplantation were not associated with osteoporosis or BMD one month after transplantation. None of the UT concentrations were associated with BMD changes and the occurrence of osteoporotic fractures 12 and 24 months after transplantation. Hence, UT concentrations at the time of kidney transplantation were not predictive markers of osteoporosis or fractures. |
| first_indexed | 2024-03-10T14:52:50Z |
| format | Article |
| id | doaj.art-62959a0dab984bd09b01d28ba904560e |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T14:52:50Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-62959a0dab984bd09b01d28ba904560e2023-11-20T20:49:52ZengMDPI AGToxins2072-66512020-11-01121171510.3390/toxins12110715Association between Uremic Toxin Concentrations and Bone Mineral Density after Kidney TransplantationBenjamin Batteux0Sandra Bodeau1Camille André2Anne-Sophie Hurtel-Lemaire3Valérie Gras-Champel4Isabelle Desailly-Henry5Kamel Masmoudi6Youssef Bennis7Ziad A. Massy8Saïd Kamel9Gabriel Choukroun10Sophie Liabeuf11Department of Pharmacology, Amiens University Medical Center, F-80000 Amiens, FranceDepartment of Pharmacology, Amiens University Medical Center, F-80000 Amiens, FranceDepartment of Pharmacology, Amiens University Medical Center, F-80000 Amiens, FranceDepartment of Pharmacology, Amiens University Medical Center, F-80000 Amiens, FranceDepartment of Pharmacology, Amiens University Medical Center, F-80000 Amiens, FranceDepartment of Rheumatology, Amiens University Medical Center, F-80000 Amiens, FranceDepartment of Pharmacology, Amiens University Medical Center, F-80000 Amiens, FranceDepartment of Pharmacology, Amiens University Medical Center, F-80000 Amiens, FranceDepartment of Nephrology, Ambroise Paré University Hospital, APHP, Boulogne Billancourt, F-92100 Paris, FranceMP3CV Laboratory, EA7517, Jules Verne University of Picardie, F-80000 Amiens, FranceMP3CV Laboratory, EA7517, Jules Verne University of Picardie, F-80000 Amiens, FranceDepartment of Pharmacology, Amiens University Medical Center, F-80000 Amiens, FranceAlthough uremic osteoporosis is a component of mineral and bone disorder in chronic kidney disease, uremic toxin (UT) concentrations in patients with end-stage kidney disease and bone mineral density (BMD) changes after kidney transplantation have not previously been described. We hypothesized that elevated UT concentrations at the time of transplantation could have a negative impact on bone during the early post-transplantation period. Hence, we sought to determine whether concentrations of UTs (trimethylamine-N-oxide, indoxylsulfate, p-cresylsulfate, p-cresylglucuronide, indole-3-acetic acid, hippuric acid, and 3-carboxy-4-methyl-5-propyl-furanpropionic acid) upon transplantation are predictive markers for (i) osteoporosis one month after transplantation, and (ii) a BMD decrease and the occurrence of fractures 12 and 24 months after kidney transplantation. Between 2012 and 2018, 310 kidney transplant recipients were included, and dual-energy X-ray absorptiometry was performed 1, 12, and 24 months after transplantation. The UT concentrations upon transplantation were determined by reverse-phase high-performance liquid chromatography. Indoxylsulfate concentrations upon transplantation were positively correlated with BMD one month after transplantation for the femoral neck but were not associated with osteoporosis status upon transplantation. Concentrations of the other UTs upon transplantation were not associated with osteoporosis or BMD one month after transplantation. None of the UT concentrations were associated with BMD changes and the occurrence of osteoporotic fractures 12 and 24 months after transplantation. Hence, UT concentrations at the time of kidney transplantation were not predictive markers of osteoporosis or fractures.https://www.mdpi.com/2072-6651/12/11/715uremic toxinbone mineral densityfracturekidney transplantation |
| spellingShingle | Benjamin Batteux Sandra Bodeau Camille André Anne-Sophie Hurtel-Lemaire Valérie Gras-Champel Isabelle Desailly-Henry Kamel Masmoudi Youssef Bennis Ziad A. Massy Saïd Kamel Gabriel Choukroun Sophie Liabeuf Association between Uremic Toxin Concentrations and Bone Mineral Density after Kidney Transplantation Toxins uremic toxin bone mineral density fracture kidney transplantation |
| title | Association between Uremic Toxin Concentrations and Bone Mineral Density after Kidney Transplantation |
| title_full | Association between Uremic Toxin Concentrations and Bone Mineral Density after Kidney Transplantation |
| title_fullStr | Association between Uremic Toxin Concentrations and Bone Mineral Density after Kidney Transplantation |
| title_full_unstemmed | Association between Uremic Toxin Concentrations and Bone Mineral Density after Kidney Transplantation |
| title_short | Association between Uremic Toxin Concentrations and Bone Mineral Density after Kidney Transplantation |
| title_sort | association between uremic toxin concentrations and bone mineral density after kidney transplantation |
| topic | uremic toxin bone mineral density fracture kidney transplantation |
| url | https://www.mdpi.com/2072-6651/12/11/715 |
| work_keys_str_mv | AT benjaminbatteux associationbetweenuremictoxinconcentrationsandbonemineraldensityafterkidneytransplantation AT sandrabodeau associationbetweenuremictoxinconcentrationsandbonemineraldensityafterkidneytransplantation AT camilleandre associationbetweenuremictoxinconcentrationsandbonemineraldensityafterkidneytransplantation AT annesophiehurtellemaire associationbetweenuremictoxinconcentrationsandbonemineraldensityafterkidneytransplantation AT valeriegraschampel associationbetweenuremictoxinconcentrationsandbonemineraldensityafterkidneytransplantation AT isabelledesaillyhenry associationbetweenuremictoxinconcentrationsandbonemineraldensityafterkidneytransplantation AT kamelmasmoudi associationbetweenuremictoxinconcentrationsandbonemineraldensityafterkidneytransplantation AT youssefbennis associationbetweenuremictoxinconcentrationsandbonemineraldensityafterkidneytransplantation AT ziadamassy associationbetweenuremictoxinconcentrationsandbonemineraldensityafterkidneytransplantation AT saidkamel associationbetweenuremictoxinconcentrationsandbonemineraldensityafterkidneytransplantation AT gabrielchoukroun associationbetweenuremictoxinconcentrationsandbonemineraldensityafterkidneytransplantation AT sophieliabeuf associationbetweenuremictoxinconcentrationsandbonemineraldensityafterkidneytransplantation |