Almonertinib-induced interstitial lung disease in a lung adenocarcinoma patient complicated with interstitial lung abnormality
Abstract Background With the use of targeted drugs in lung cancer patients, targeted drug-induced interstitial lung disease (ILD) has attracted more and more attention. The incidence, time, and severity of different targeted drug-induced ILD vary. Almonertinib/HS-10296 is a third-generation epiderma...
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12890-023-02367-x |
| _version_ | 1797865672276967424 |
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| author | Qian Zhou Zhong Hu Xin Li Xiaokui Tang |
| author_facet | Qian Zhou Zhong Hu Xin Li Xiaokui Tang |
| author_sort | Qian Zhou |
| collection | DOAJ |
| description | Abstract Background With the use of targeted drugs in lung cancer patients, targeted drug-induced interstitial lung disease (ILD) has attracted more and more attention. The incidence, time, and severity of different targeted drug-induced ILD vary. Almonertinib/HS-10296 is a third-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI). Post-marketing safety and effectiveness of almonertinib have been confirmed. The reported adverse events of almonertinib were mainly an increase in creatine phosphokinase, aspartate aminotransferase, and alanine aminotransferase, and onset of rash. Almonertinib-induced ILD is rare. Case report This paper reported the case of a patient with lung adenocarcinoma complicated with interstitial lung abnormality (ILA). Gene detection showed L858R mutation in exon 21 of the EGFR gene. After operation, almonertinib (110 mg per day) was prescribed. 3 months later, ILD was found by chest CT due to dyspnea. Management and outcome Subsequently, almonertinib was stopped. With the administration of intravenous glucocorticoid and oxygen inhalation, the patient's dyspnea was significantly regressed and lung lesions regressed on follow-up chest CT done after discharge. Discussion This case suggested that we should pay attention to the existence of ILD/ILA before using targeted drugs. The use of targeted drugs should be more strictly controlled and monitored in patients with previous ILA or ILD. This paper also reviewed the relevant literature on the drug characteristics and summarized the risk factors of ILD caused by EGFR-TKI. |
| first_indexed | 2024-04-09T23:11:56Z |
| format | Article |
| id | doaj.art-62971449985b4299b606bf45fd71c41e |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-04-09T23:11:56Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-62971449985b4299b606bf45fd71c41e2023-03-22T10:19:02ZengBMCBMC Pulmonary Medicine1471-24662023-03-012311810.1186/s12890-023-02367-xAlmonertinib-induced interstitial lung disease in a lung adenocarcinoma patient complicated with interstitial lung abnormalityQian Zhou0Zhong Hu1Xin Li2Xiaokui Tang3Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Respiratory and Critical Care Medicine, The First People’s Hospital of Chongqing Liang Jiang New AreaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical UniversityAbstract Background With the use of targeted drugs in lung cancer patients, targeted drug-induced interstitial lung disease (ILD) has attracted more and more attention. The incidence, time, and severity of different targeted drug-induced ILD vary. Almonertinib/HS-10296 is a third-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI). Post-marketing safety and effectiveness of almonertinib have been confirmed. The reported adverse events of almonertinib were mainly an increase in creatine phosphokinase, aspartate aminotransferase, and alanine aminotransferase, and onset of rash. Almonertinib-induced ILD is rare. Case report This paper reported the case of a patient with lung adenocarcinoma complicated with interstitial lung abnormality (ILA). Gene detection showed L858R mutation in exon 21 of the EGFR gene. After operation, almonertinib (110 mg per day) was prescribed. 3 months later, ILD was found by chest CT due to dyspnea. Management and outcome Subsequently, almonertinib was stopped. With the administration of intravenous glucocorticoid and oxygen inhalation, the patient's dyspnea was significantly regressed and lung lesions regressed on follow-up chest CT done after discharge. Discussion This case suggested that we should pay attention to the existence of ILD/ILA before using targeted drugs. The use of targeted drugs should be more strictly controlled and monitored in patients with previous ILA or ILD. This paper also reviewed the relevant literature on the drug characteristics and summarized the risk factors of ILD caused by EGFR-TKI.https://doi.org/10.1186/s12890-023-02367-xAlmonertinibInterstitial lung diseaseEGFR-TKILung adenocarcinomaCase report |
| spellingShingle | Qian Zhou Zhong Hu Xin Li Xiaokui Tang Almonertinib-induced interstitial lung disease in a lung adenocarcinoma patient complicated with interstitial lung abnormality BMC Pulmonary Medicine Almonertinib Interstitial lung disease EGFR-TKI Lung adenocarcinoma Case report |
| title | Almonertinib-induced interstitial lung disease in a lung adenocarcinoma patient complicated with interstitial lung abnormality |
| title_full | Almonertinib-induced interstitial lung disease in a lung adenocarcinoma patient complicated with interstitial lung abnormality |
| title_fullStr | Almonertinib-induced interstitial lung disease in a lung adenocarcinoma patient complicated with interstitial lung abnormality |
| title_full_unstemmed | Almonertinib-induced interstitial lung disease in a lung adenocarcinoma patient complicated with interstitial lung abnormality |
| title_short | Almonertinib-induced interstitial lung disease in a lung adenocarcinoma patient complicated with interstitial lung abnormality |
| title_sort | almonertinib induced interstitial lung disease in a lung adenocarcinoma patient complicated with interstitial lung abnormality |
| topic | Almonertinib Interstitial lung disease EGFR-TKI Lung adenocarcinoma Case report |
| url | https://doi.org/10.1186/s12890-023-02367-x |
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