Fluorescent properties and protein-ligand interactions of boron dipyrromethene molecular rotor
A fluorescent molecular rotor (FMR) based on boron dipyrromethene core was obtained. Fluorescence emission properties of the compound strongly depend on the medium viscosity. The emission intensity increases 27 times after viscosity changing from ethanol to glycerol medium. At the same time, the com...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Belarusian |
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Belarusian State University
2022-04-01
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| Series: | Журнал Белорусского государственного университета: Химия |
| Subjects: | |
| Online Access: | https://journals.bsu.by/index.php/chemistry/article/view/4284 |
| _version_ | 1828805017539182592 |
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| author | Anastasiya Dudko Matvey S. Horetski Nina S. Frolova Yaroslav V. Faletrov Vladimir M. Shkumatov |
| author_facet | Anastasiya Dudko Matvey S. Horetski Nina S. Frolova Yaroslav V. Faletrov Vladimir M. Shkumatov |
| author_sort | Anastasiya Dudko |
| collection | DOAJ |
| description | A fluorescent molecular rotor (FMR) based on boron dipyrromethene core was obtained. Fluorescence emission properties of the compound strongly depend on the medium viscosity. The emission intensity increases 27 times after viscosity changing from ethanol to glycerol medium. At the same time, the compound appeared almost insensitive to solvatochromic effects. Obtained FMR also can affinely bind with the bovine serum albumin protein active sites followed by noticeable emission intensity growth. Possible ligand binding cites and main amino acid surrounding were described with molecular docking simulations and are in an agreement with experimental data. The results can be used for further design and synthesis of novel fluorescent viscosity and protein-ligand interactions censors suitable for implementation in biosystems in vitro and in vivo. |
| first_indexed | 2024-12-12T07:48:43Z |
| format | Article |
| id | doaj.art-6297328754234b22b514f3f194af4a52 |
| institution | Directory Open Access Journal |
| issn | 2520-257X 2617-3980 |
| language | Belarusian |
| last_indexed | 2024-12-12T07:48:43Z |
| publishDate | 2022-04-01 |
| publisher | Belarusian State University |
| record_format | Article |
| series | Журнал Белорусского государственного университета: Химия |
| spelling | doaj.art-6297328754234b22b514f3f194af4a522022-12-22T00:32:30ZbelBelarusian State UniversityЖурнал Белорусского государственного университета: Химия2520-257X2617-39802022-04-011617110.33581/2520-257X-2022-1-61-714284Fluorescent properties and protein-ligand interactions of boron dipyrromethene molecular rotorAnastasiya Dudko0https://orcid.org/0000-0002-9961-5587Matvey S. Horetski1https://orcid.org/0000-0003-3065-6214Nina S. Frolova2Yaroslav V. Faletrov3Vladimir M. Shkumatov4Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, BelarusResearch Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, BelarusResearch Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, BelarusResearch Institute for Physical Chemical Problems, Belarusian State University; 14 Lieninhradskaja Street, Minsk 220006, Belarus; Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, BelarusResearch Institute for Physical Chemical Problems of the Belarusian State University, 14, Leningradskaya str., 220030 Minsk, Republic of BelarusA fluorescent molecular rotor (FMR) based on boron dipyrromethene core was obtained. Fluorescence emission properties of the compound strongly depend on the medium viscosity. The emission intensity increases 27 times after viscosity changing from ethanol to glycerol medium. At the same time, the compound appeared almost insensitive to solvatochromic effects. Obtained FMR also can affinely bind with the bovine serum albumin protein active sites followed by noticeable emission intensity growth. Possible ligand binding cites and main amino acid surrounding were described with molecular docking simulations and are in an agreement with experimental data. The results can be used for further design and synthesis of novel fluorescent viscosity and protein-ligand interactions censors suitable for implementation in biosystems in vitro and in vivo.https://journals.bsu.by/index.php/chemistry/article/view/4284бордипиррометенбычий сывороточный альбуминмолекулярный докингмолекулярный роторфлуоресценция |
| spellingShingle | Anastasiya Dudko Matvey S. Horetski Nina S. Frolova Yaroslav V. Faletrov Vladimir M. Shkumatov Fluorescent properties and protein-ligand interactions of boron dipyrromethene molecular rotor Журнал Белорусского государственного университета: Химия бордипиррометен бычий сывороточный альбумин молекулярный докинг молекулярный ротор флуоресценция |
| title | Fluorescent properties and protein-ligand interactions of boron dipyrromethene molecular rotor |
| title_full | Fluorescent properties and protein-ligand interactions of boron dipyrromethene molecular rotor |
| title_fullStr | Fluorescent properties and protein-ligand interactions of boron dipyrromethene molecular rotor |
| title_full_unstemmed | Fluorescent properties and protein-ligand interactions of boron dipyrromethene molecular rotor |
| title_short | Fluorescent properties and protein-ligand interactions of boron dipyrromethene molecular rotor |
| title_sort | fluorescent properties and protein ligand interactions of boron dipyrromethene molecular rotor |
| topic | бордипиррометен бычий сывороточный альбумин молекулярный докинг молекулярный ротор флуоресценция |
| url | https://journals.bsu.by/index.php/chemistry/article/view/4284 |
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