Bioactive Compounds from Plant Origin as Natural Antimicrobial Agents for the Treatment of Wound Infections
The rising prevalence of drug-resistant bacteria underscores the need to search for innovative and nature-based solutions. One of the approaches may be the use of plants that constitute a rich source of miscellaneous compounds with a wide range of biological properties. This review explores the anti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/4/2100 |
| _version_ | 1797298005269807104 |
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| author | Katarzyna Pacyga Paweł Pacyga Ewa Topola Szymon Viscardi Anna Duda-Madej |
| author_facet | Katarzyna Pacyga Paweł Pacyga Ewa Topola Szymon Viscardi Anna Duda-Madej |
| author_sort | Katarzyna Pacyga |
| collection | DOAJ |
| description | The rising prevalence of drug-resistant bacteria underscores the need to search for innovative and nature-based solutions. One of the approaches may be the use of plants that constitute a rich source of miscellaneous compounds with a wide range of biological properties. This review explores the antimicrobial activity of seven bioactives and their possible molecular mechanisms of action. Special attention was focused on the antibacterial properties of berberine, catechin, chelerythrine, cinnamaldehyde, ellagic acid, proanthocyanidin, and sanguinarine against <i>Staphylococcus aureus</i>, <i>Enterococcus</i> spp., <i>Klebsiella pneumoniae</i>, <i>Acinetobacter baumannii</i>, <i>Escherichia coli</i>, <i>Serratia marcescens</i> and <i>Pseudomonas aeruginosa</i>. The growing interest in novel therapeutic strategies based on new plant-derived formulations was confirmed by the growing number of articles. Natural products are one of the most promising and intensively examined agents to combat the consequences of the overuse and misuse of classical antibiotics. |
| first_indexed | 2024-03-07T22:29:38Z |
| format | Article |
| id | doaj.art-62983930f96f45178b2761f216bc82a6 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-07T22:29:38Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-62983930f96f45178b2761f216bc82a62024-02-23T15:19:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-02-01254210010.3390/ijms25042100Bioactive Compounds from Plant Origin as Natural Antimicrobial Agents for the Treatment of Wound InfectionsKatarzyna Pacyga0Paweł Pacyga1Ewa Topola2Szymon Viscardi3Anna Duda-Madej4Department of Environment Hygiene and Animal Welfare, Faculty of Biology and Animal Science, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, PolandDepartment of Thermodynamics and Renewable Energy Sources, Faculty of Mechanical and Power Engineering, Wrocław University of Science and Technology, 50-370 Wrocław, PolandFaculty of Medicine, Wroclaw Medical University, Ludwika Pasteura 1, 50-367 Wrocław, PolandFaculty of Medicine, Wroclaw Medical University, Ludwika Pasteura 1, 50-367 Wrocław, PolandDepartment of Microbiology, Faculty of Medicine, Wroclaw Medical University, Chałubińskiego 4, 50-368 Wrocław, PolandThe rising prevalence of drug-resistant bacteria underscores the need to search for innovative and nature-based solutions. One of the approaches may be the use of plants that constitute a rich source of miscellaneous compounds with a wide range of biological properties. This review explores the antimicrobial activity of seven bioactives and their possible molecular mechanisms of action. Special attention was focused on the antibacterial properties of berberine, catechin, chelerythrine, cinnamaldehyde, ellagic acid, proanthocyanidin, and sanguinarine against <i>Staphylococcus aureus</i>, <i>Enterococcus</i> spp., <i>Klebsiella pneumoniae</i>, <i>Acinetobacter baumannii</i>, <i>Escherichia coli</i>, <i>Serratia marcescens</i> and <i>Pseudomonas aeruginosa</i>. The growing interest in novel therapeutic strategies based on new plant-derived formulations was confirmed by the growing number of articles. Natural products are one of the most promising and intensively examined agents to combat the consequences of the overuse and misuse of classical antibiotics.https://www.mdpi.com/1422-0067/25/4/2100plantsbioactive compoundsantibacterial activitymolecular effectsdrug-resistant bacteria |
| spellingShingle | Katarzyna Pacyga Paweł Pacyga Ewa Topola Szymon Viscardi Anna Duda-Madej Bioactive Compounds from Plant Origin as Natural Antimicrobial Agents for the Treatment of Wound Infections International Journal of Molecular Sciences plants bioactive compounds antibacterial activity molecular effects drug-resistant bacteria |
| title | Bioactive Compounds from Plant Origin as Natural Antimicrobial Agents for the Treatment of Wound Infections |
| title_full | Bioactive Compounds from Plant Origin as Natural Antimicrobial Agents for the Treatment of Wound Infections |
| title_fullStr | Bioactive Compounds from Plant Origin as Natural Antimicrobial Agents for the Treatment of Wound Infections |
| title_full_unstemmed | Bioactive Compounds from Plant Origin as Natural Antimicrobial Agents for the Treatment of Wound Infections |
| title_short | Bioactive Compounds from Plant Origin as Natural Antimicrobial Agents for the Treatment of Wound Infections |
| title_sort | bioactive compounds from plant origin as natural antimicrobial agents for the treatment of wound infections |
| topic | plants bioactive compounds antibacterial activity molecular effects drug-resistant bacteria |
| url | https://www.mdpi.com/1422-0067/25/4/2100 |
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