Phytotoxic and Cytotoxic Polyketides Produced by Fungal Endophytes Isolated from Psidium guajava
Endophytic fungi reside within their host plants with no obvious symptoms. They have been proven as abundant sources of new bioactive compounds with diverse structures. In our continuous search of the new compound from endophytic fungi, a new compound, 5,7-dihydroxy-3(R)-methylphthalide (1), was is...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Bogor Agricultural University
2023-01-01
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| Series: | Hayati Journal of Biosciences |
| Online Access: | https://journal.ipb.ac.id/index.php/hayati/article/view/39161 |
| _version_ | 1827998350877655040 |
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| author | Tendy Oktriawan Nanang Ariefta Tri Joko Raharjo Endang Astuti Takuya Koseki Yoshihito Shiono |
| author_facet | Tendy Oktriawan Nanang Ariefta Tri Joko Raharjo Endang Astuti Takuya Koseki Yoshihito Shiono |
| author_sort | Tendy Oktriawan |
| collection | DOAJ |
| description |
Endophytic fungi reside within their host plants with no obvious symptoms. They have been proven as abundant sources of new bioactive compounds with diverse structures. In our continuous search of the new compound from endophytic fungi, a new compound, 5,7-dihydroxy-3(R)-methylphthalide (1), was isolated from Xylaria brevipes PGR1, and three known compounds, (–)-altenuene (2), alternariol (3), and altertoxin I (4), were isolated from Alternaria alternata D-8. Both endophytic fungi were isolated from the branch of an Indonesian medicinal plant, Psidium guajava. Their structures were elucidated using extensive spectroscopy analyses, including 1D/2D NMR, HRESITOFMS, and data comparisons with the literature. Compounds 1–3 exhibited phytotoxicity at IC50 (µg/ml) values of 4.6, 23.07, and 77.28, respectively. Additionally, 1–4 showed significant cytotoxicity in the brine shrimp lethality test (BSLT), with mortality rates at 75%, 50%, 90%, and 80% at the concentration of 0.19 μg/ml, respectively.
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| first_indexed | 2024-04-10T05:42:05Z |
| format | Article |
| id | doaj.art-629af4571d7946d49b28ffff4409d4a1 |
| institution | Directory Open Access Journal |
| issn | 1978-3019 2086-4094 |
| language | English |
| last_indexed | 2024-04-10T05:42:05Z |
| publishDate | 2023-01-01 |
| publisher | Bogor Agricultural University |
| record_format | Article |
| series | Hayati Journal of Biosciences |
| spelling | doaj.art-629af4571d7946d49b28ffff4409d4a12023-03-06T07:57:47ZengBogor Agricultural UniversityHayati Journal of Biosciences1978-30192086-40942023-01-0130310.4308/hjb.30.3.473-479Phytotoxic and Cytotoxic Polyketides Produced by Fungal Endophytes Isolated from Psidium guajavaTendy Oktriawan0Nanang Ariefta1Tri Joko Raharjo2Endang Astuti3Takuya Koseki4Yoshihito Shiono5Department of Food, Life, and Environmental Sciences, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Bulaksumur, Yogyakarta 55281, IndonesiaDepartment of Food, Life, and Environmental Sciences, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, JapanDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Bulaksumur, Yogyakarta 55281, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Bulaksumur, Yogyakarta 55281, IndonesiaDepartment of Food, Life, and Environmental Sciences, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, JapanDepartment of Food, Life, and Environmental Sciences, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan Endophytic fungi reside within their host plants with no obvious symptoms. They have been proven as abundant sources of new bioactive compounds with diverse structures. In our continuous search of the new compound from endophytic fungi, a new compound, 5,7-dihydroxy-3(R)-methylphthalide (1), was isolated from Xylaria brevipes PGR1, and three known compounds, (–)-altenuene (2), alternariol (3), and altertoxin I (4), were isolated from Alternaria alternata D-8. Both endophytic fungi were isolated from the branch of an Indonesian medicinal plant, Psidium guajava. Their structures were elucidated using extensive spectroscopy analyses, including 1D/2D NMR, HRESITOFMS, and data comparisons with the literature. Compounds 1–3 exhibited phytotoxicity at IC50 (µg/ml) values of 4.6, 23.07, and 77.28, respectively. Additionally, 1–4 showed significant cytotoxicity in the brine shrimp lethality test (BSLT), with mortality rates at 75%, 50%, 90%, and 80% at the concentration of 0.19 μg/ml, respectively. https://journal.ipb.ac.id/index.php/hayati/article/view/39161 |
| spellingShingle | Tendy Oktriawan Nanang Ariefta Tri Joko Raharjo Endang Astuti Takuya Koseki Yoshihito Shiono Phytotoxic and Cytotoxic Polyketides Produced by Fungal Endophytes Isolated from Psidium guajava Hayati Journal of Biosciences |
| title | Phytotoxic and Cytotoxic Polyketides Produced by Fungal Endophytes Isolated from Psidium guajava |
| title_full | Phytotoxic and Cytotoxic Polyketides Produced by Fungal Endophytes Isolated from Psidium guajava |
| title_fullStr | Phytotoxic and Cytotoxic Polyketides Produced by Fungal Endophytes Isolated from Psidium guajava |
| title_full_unstemmed | Phytotoxic and Cytotoxic Polyketides Produced by Fungal Endophytes Isolated from Psidium guajava |
| title_short | Phytotoxic and Cytotoxic Polyketides Produced by Fungal Endophytes Isolated from Psidium guajava |
| title_sort | phytotoxic and cytotoxic polyketides produced by fungal endophytes isolated from psidium guajava |
| url | https://journal.ipb.ac.id/index.php/hayati/article/view/39161 |
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