Granular cell tumor: rare presentation in pediatric age
Granular cell tumors (GCT) are rare soft tissue neoplasms that usually present as solitary lesions, although occasionally, they may be multiple. Most of these tumors arise in the oral mucosa and skin of adults, usually evolving as a slow-growing tumors. It is considered very rare in children. Malign...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Portuguesa de Dermatologia e Venereologia
2023-04-01
|
| Series: | Revista da Sociedade Portuguesa de Dermatologia e Venereologia |
| Subjects: | |
| Online Access: | https://www.portuguesejournalofdermatology.com/frame_esp.php?id=81 |
| _version_ | 1797782822022283264 |
|---|---|
| author | Pedro R. Matos Ana Nogueira Filomena Azevedo Elisabete Rios |
| author_facet | Pedro R. Matos Ana Nogueira Filomena Azevedo Elisabete Rios |
| author_sort | Pedro R. Matos |
| collection | DOAJ |
| description | Granular cell tumors (GCT) are rare soft tissue neoplasms that usually present as solitary lesions, although occasionally, they may be multiple. Most of these tumors arise in the oral mucosa and skin of adults, usually evolving as a slow-growing tumors. It is considered very rare in children. Malignant transformation is very rare, and only 2% of cases are known to spread to distant sites. Here we report a case of a 10-year-old child with a hard painless nodule on the tongue evolving for 6 months. Histopathological examination revealed infiltration of the tongue mucosa by polygonal cells with small nuclei and abundant pale eosinophilic granular cytoplasm expressing S100 protein strongly and diffusely, compatible with a granular cell tumor. A right partial glossectomy was performed. This case highlights the importance of mucosal biopsy for the diagnosis. It also emphasizes that regardless of pediatric age, a biopsy should not be postponed whenever there is uncertainty in the clinical diagnosis.
|
| first_indexed | 2024-03-13T00:17:21Z |
| format | Article |
| id | doaj.art-629ce320c68c42b09da38d5fc1fa2e56 |
| institution | Directory Open Access Journal |
| issn | 2182-2395 2182-2409 |
| language | English |
| last_indexed | 2024-03-13T00:17:21Z |
| publishDate | 2023-04-01 |
| publisher | Sociedade Portuguesa de Dermatologia e Venereologia |
| record_format | Article |
| series | Revista da Sociedade Portuguesa de Dermatologia e Venereologia |
| spelling | doaj.art-629ce320c68c42b09da38d5fc1fa2e562023-07-11T22:05:19ZengSociedade Portuguesa de Dermatologia e VenereologiaRevista da Sociedade Portuguesa de Dermatologia e Venereologia2182-23952182-24092023-04-0181210.24875/PJDV.22000047Granular cell tumor: rare presentation in pediatric agePedro R. Matos0Ana Nogueira1Filomena Azevedo2Elisabete Rios3Department of Dermatology and Venereology, Centro Hospitalar e Universitário de São João (CHUSJ), Porto, PortugalDepartment of Dermatology and Venereology, Centro Hospitalar e Universitário de São João (CHUSJ), Porto, PortugalDepartment of Dermatology and Venereology, Centro Hospitalar Universitário de São João, Porto, PortugalDepartment of Pathological Anatomy, Centro Hospitalar e Universitário de São João (CHUSJ). Porto, PortugalGranular cell tumors (GCT) are rare soft tissue neoplasms that usually present as solitary lesions, although occasionally, they may be multiple. Most of these tumors arise in the oral mucosa and skin of adults, usually evolving as a slow-growing tumors. It is considered very rare in children. Malignant transformation is very rare, and only 2% of cases are known to spread to distant sites. Here we report a case of a 10-year-old child with a hard painless nodule on the tongue evolving for 6 months. Histopathological examination revealed infiltration of the tongue mucosa by polygonal cells with small nuclei and abundant pale eosinophilic granular cytoplasm expressing S100 protein strongly and diffusely, compatible with a granular cell tumor. A right partial glossectomy was performed. This case highlights the importance of mucosal biopsy for the diagnosis. It also emphasizes that regardless of pediatric age, a biopsy should not be postponed whenever there is uncertainty in the clinical diagnosis. https://www.portuguesejournalofdermatology.com/frame_esp.php?id=81Granular cell tumor. Oral mucosa. Tongue. |
| spellingShingle | Pedro R. Matos Ana Nogueira Filomena Azevedo Elisabete Rios Granular cell tumor: rare presentation in pediatric age Revista da Sociedade Portuguesa de Dermatologia e Venereologia Granular cell tumor. Oral mucosa. Tongue. |
| title | Granular cell tumor: rare presentation in pediatric age |
| title_full | Granular cell tumor: rare presentation in pediatric age |
| title_fullStr | Granular cell tumor: rare presentation in pediatric age |
| title_full_unstemmed | Granular cell tumor: rare presentation in pediatric age |
| title_short | Granular cell tumor: rare presentation in pediatric age |
| title_sort | granular cell tumor rare presentation in pediatric age |
| topic | Granular cell tumor. Oral mucosa. Tongue. |
| url | https://www.portuguesejournalofdermatology.com/frame_esp.php?id=81 |
| work_keys_str_mv | AT pedrormatos granularcelltumorrarepresentationinpediatricage AT ananogueira granularcelltumorrarepresentationinpediatricage AT filomenaazevedo granularcelltumorrarepresentationinpediatricage AT elisabeterios granularcelltumorrarepresentationinpediatricage |