Association of dietary and nutrient patterns with systemic inflammation in community dwelling adults
PurposeEvidence investigating associations between dietary and nutrient patterns and inflammatory biomarkers is inconsistent and scarce. Therefore, we aimed to determine the association of dietary and nutrient patterns with inflammation.MethodsOverall, 1,792 participants from the North-West Adelaide...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.977029/full |
| _version_ | 1798037115539292160 |
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| author | Yoko Brigitte Wang Yoko Brigitte Wang Amanda J. Page Amanda J. Page Tiffany K. Gill Yohannes Adama Melaku Yohannes Adama Melaku Yohannes Adama Melaku Yohannes Adama Melaku |
| author_facet | Yoko Brigitte Wang Yoko Brigitte Wang Amanda J. Page Amanda J. Page Tiffany K. Gill Yohannes Adama Melaku Yohannes Adama Melaku Yohannes Adama Melaku Yohannes Adama Melaku |
| author_sort | Yoko Brigitte Wang |
| collection | DOAJ |
| description | PurposeEvidence investigating associations between dietary and nutrient patterns and inflammatory biomarkers is inconsistent and scarce. Therefore, we aimed to determine the association of dietary and nutrient patterns with inflammation.MethodsOverall, 1,792 participants from the North-West Adelaide Health Study were included in this cross-sectional study. We derived dietary and nutrient patterns from food frequency questionnaire data using principal component analysis. Multivariable ordinal logistic regression determined the association between dietary and nutrient patterns and the grade of inflammation (normal, moderate, and severe) based on C-reactive protein (CRP) values. Subgroup analyses were stratified by gender, obesity and metabolic health status.ResultsIn the fully adjusted model, a plant-sourced nutrient pattern (NP) was strongly associated with a lower grade of inflammation in men (ORQ5vsQ1 = 0.59, 95% CI: 0.38–0.93, p-trend = 0.08), obesity (ORQ5vsQ1 = 0.43; 95% CI: 0.24–0.77, p-trend = 0.03) and metabolically unhealthy obesity (ORQ5vsQ1 = 0.24; 95% CI: 0.11–0.52, p-trend = 0.01). A mixed NP was positively associated with higher grade of inflammation (ORQ5vsQ1 = 1.35; 95% CI: 0.99–1.84, p-trend = 0.03) in all participants. A prudent dietary pattern was inversely associated with a lower grade of inflammation (ORQ5vsQ1 = 0.72, 95% CI: 0.52–1.01, p-trend = 0.14). In contrast, a western dietary pattern and animal-sourced NP were associated with a higher grade of inflammation in the all participants although BMI attenuated the magnitude of association (ORQ5vsQ1 = 0.83, 95% CI: 0.55–1.25; and ORQ5vsQ1 = 0.94, 95% CI: 0.63–1.39, respectively) in the fully adjusted model.ConclusionA plant-sourced NP was independently associated with lower inflammation. The association was stronger in men, and those classified as obese and metabolically unhealthy obese. Increasing consumption of plant-based foods may mitigate obesity-induced inflammation and its consequences. |
| first_indexed | 2024-04-11T21:22:11Z |
| format | Article |
| id | doaj.art-629da942bc3a41329f0c1e93d1324713 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-11T21:22:11Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-629da942bc3a41329f0c1e93d13247132022-12-22T04:02:35ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-08-01910.3389/fnut.2022.977029977029Association of dietary and nutrient patterns with systemic inflammation in community dwelling adultsYoko Brigitte Wang0Yoko Brigitte Wang1Amanda J. Page2Amanda J. Page3Tiffany K. Gill4Yohannes Adama Melaku5Yohannes Adama Melaku6Yohannes Adama Melaku7Yohannes Adama Melaku8Vagal Afferent Research Group, School of Biomedicine, University of Adelaide, Adelaide, SA, AustraliaNutrition, Diabetes and Gut Health, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA, AustraliaVagal Afferent Research Group, School of Biomedicine, University of Adelaide, Adelaide, SA, AustraliaNutrition, Diabetes and Gut Health, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA, AustraliaAdelaide Medical School, The University of Adelaide, Adelaide, SA, AustraliaNutrition, Diabetes and Gut Health, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA, AustraliaAdelaide Medical School, The University of Adelaide, Adelaide, SA, AustraliaAdelaide Institute for Sleep Health, College of Medicine and Public Health, Flinders University, Bedford Park, SA, AustraliaCancer Council Victoria, Cancer Epidemiology Division, Melbourne, VIC, AustraliaPurposeEvidence investigating associations between dietary and nutrient patterns and inflammatory biomarkers is inconsistent and scarce. Therefore, we aimed to determine the association of dietary and nutrient patterns with inflammation.MethodsOverall, 1,792 participants from the North-West Adelaide Health Study were included in this cross-sectional study. We derived dietary and nutrient patterns from food frequency questionnaire data using principal component analysis. Multivariable ordinal logistic regression determined the association between dietary and nutrient patterns and the grade of inflammation (normal, moderate, and severe) based on C-reactive protein (CRP) values. Subgroup analyses were stratified by gender, obesity and metabolic health status.ResultsIn the fully adjusted model, a plant-sourced nutrient pattern (NP) was strongly associated with a lower grade of inflammation in men (ORQ5vsQ1 = 0.59, 95% CI: 0.38–0.93, p-trend = 0.08), obesity (ORQ5vsQ1 = 0.43; 95% CI: 0.24–0.77, p-trend = 0.03) and metabolically unhealthy obesity (ORQ5vsQ1 = 0.24; 95% CI: 0.11–0.52, p-trend = 0.01). A mixed NP was positively associated with higher grade of inflammation (ORQ5vsQ1 = 1.35; 95% CI: 0.99–1.84, p-trend = 0.03) in all participants. A prudent dietary pattern was inversely associated with a lower grade of inflammation (ORQ5vsQ1 = 0.72, 95% CI: 0.52–1.01, p-trend = 0.14). In contrast, a western dietary pattern and animal-sourced NP were associated with a higher grade of inflammation in the all participants although BMI attenuated the magnitude of association (ORQ5vsQ1 = 0.83, 95% CI: 0.55–1.25; and ORQ5vsQ1 = 0.94, 95% CI: 0.63–1.39, respectively) in the fully adjusted model.ConclusionA plant-sourced NP was independently associated with lower inflammation. The association was stronger in men, and those classified as obese and metabolically unhealthy obese. Increasing consumption of plant-based foods may mitigate obesity-induced inflammation and its consequences.https://www.frontiersin.org/articles/10.3389/fnut.2022.977029/fullnutrient patterndietary patterninflammationC-reactive proteinobesity |
| spellingShingle | Yoko Brigitte Wang Yoko Brigitte Wang Amanda J. Page Amanda J. Page Tiffany K. Gill Yohannes Adama Melaku Yohannes Adama Melaku Yohannes Adama Melaku Yohannes Adama Melaku Association of dietary and nutrient patterns with systemic inflammation in community dwelling adults Frontiers in Nutrition nutrient pattern dietary pattern inflammation C-reactive protein obesity |
| title | Association of dietary and nutrient patterns with systemic inflammation in community dwelling adults |
| title_full | Association of dietary and nutrient patterns with systemic inflammation in community dwelling adults |
| title_fullStr | Association of dietary and nutrient patterns with systemic inflammation in community dwelling adults |
| title_full_unstemmed | Association of dietary and nutrient patterns with systemic inflammation in community dwelling adults |
| title_short | Association of dietary and nutrient patterns with systemic inflammation in community dwelling adults |
| title_sort | association of dietary and nutrient patterns with systemic inflammation in community dwelling adults |
| topic | nutrient pattern dietary pattern inflammation C-reactive protein obesity |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.977029/full |
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