Buyang Huanwu decoction facilitates neurorehabilitation through an improvement of synaptic plasticity in cerebral ischemic rats
Abstract Background Loss of neural function is a critical but unsolved issue after cerebral ischemia insult. Neuronal plasticity and remodeling are crucial for recovery of neural functions after brain injury. Buyang Huanwu decoction, which is a classic formula in traditional Chinese medicine, can po...
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| Format: | Article |
| Language: | English |
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BMC
2017-03-01
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| Series: | BMC Complementary and Alternative Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12906-017-1680-9 |
| _version_ | 1811208176656187392 |
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| author | Ruihuan Pan Jun Cai Lechang Zhan Youhua Guo Run-Yue Huang Xiong Li Mingchao Zhou Dandan Xu Jie Zhan Hongxia Chen |
| author_facet | Ruihuan Pan Jun Cai Lechang Zhan Youhua Guo Run-Yue Huang Xiong Li Mingchao Zhou Dandan Xu Jie Zhan Hongxia Chen |
| author_sort | Ruihuan Pan |
| collection | DOAJ |
| description | Abstract Background Loss of neural function is a critical but unsolved issue after cerebral ischemia insult. Neuronal plasticity and remodeling are crucial for recovery of neural functions after brain injury. Buyang Huanwu decoction, which is a classic formula in traditional Chinese medicine, can positively alter synaptic plasticity. This study assessed the effects of Buyang Huanwu decoction in combination with physical exercise on neuronal plasticity in cerebral ischemic rats. Methods Cerebral ischemic rats were administered Buyang Huanwu decoction and participated in physical exercise after the induction of a permanent middle cerebral artery occlusion. The neurobehavioral functions and infarct volumes were evaluated. The presynaptic (SYN), postsynaptic (GAP-43) and cytoskeletal (MAP-2) proteins in the coronal brain samples were evaluated by immunohistochemistry and western blot analyses. The ultrastructure of the neuronal synaptic junctions in the same region were analyzed using transmission electron microscopy. Results Combination treatment of Buyang Huanwu decoction and physical exercise ameliorated the neurobehavioral deficits (p < 0.05), significantly enhanced the expression levels of SYN, GAP-43 and MAP-2 (p < 0.05), and maintained the synaptic ultrastructure. Conclusions Buyang Huanwu decoction facilitated neurorehabilitation following a cerebral ischemia insult through an improvement in synaptic plasticity. Graphical abstract The Buyang Huanwu decoction (BYHWD) combined with physical exercise (PE) attenuates synaptic disruption and promotes synaptic plasticity following cerebral ischemia (stroke). |
| first_indexed | 2024-04-12T04:17:45Z |
| format | Article |
| id | doaj.art-629e4f614cd64187a08a99a9a34bbcdc |
| institution | Directory Open Access Journal |
| issn | 1472-6882 |
| language | English |
| last_indexed | 2024-04-12T04:17:45Z |
| publishDate | 2017-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Complementary and Alternative Medicine |
| spelling | doaj.art-629e4f614cd64187a08a99a9a34bbcdc2022-12-22T03:48:20ZengBMCBMC Complementary and Alternative Medicine1472-68822017-03-0117111110.1186/s12906-017-1680-9Buyang Huanwu decoction facilitates neurorehabilitation through an improvement of synaptic plasticity in cerebral ischemic ratsRuihuan Pan0Jun Cai1Lechang Zhan2Youhua Guo3Run-Yue Huang4Xiong Li5Mingchao Zhou6Dandan Xu7Jie Zhan8Hongxia Chen9Department of Rehabilitation, Hospital of Guangzhou Higher Education Mega Center, Guangdong Provincial Hospital of Chinese MedicineDepartment of Neurosurgery, Hospital of Guangzhou Higher Education Mega Center, Guangdong Provincial Hospital of Chinese MedicineDepartment of Rehabilitation, Hospital of Guangzhou Higher Education Mega Center, Guangdong Provincial Hospital of Chinese MedicineDepartment of Rehabilitation, Hospital of Guangzhou Higher Education Mega Center, Guangdong Provincial Hospital of Chinese MedicineDepartment of Rheumatism, Hospital of Guangzhou Higher Education Mega Center, Guangdong Provincial Hospital of Chinese MedicinePhase 1 Clinical Research Center, Guangdong Provincial Hospital of Chinese MedicineDepartment of Rehabilitation, Hospital of Guangzhou Higher Education Mega Center, Guangdong Provincial Hospital of Chinese MedicineThe Second Institute of Clinical Medicine, Guangzhou University of Chinese MedicineDepartment of Rehabilitation, Hospital of Guangzhou Higher Education Mega Center, Guangdong Provincial Hospital of Chinese MedicineDepartment of Rehabilitation, Hospital of Guangzhou Higher Education Mega Center, Guangdong Provincial Hospital of Chinese MedicineAbstract Background Loss of neural function is a critical but unsolved issue after cerebral ischemia insult. Neuronal plasticity and remodeling are crucial for recovery of neural functions after brain injury. Buyang Huanwu decoction, which is a classic formula in traditional Chinese medicine, can positively alter synaptic plasticity. This study assessed the effects of Buyang Huanwu decoction in combination with physical exercise on neuronal plasticity in cerebral ischemic rats. Methods Cerebral ischemic rats were administered Buyang Huanwu decoction and participated in physical exercise after the induction of a permanent middle cerebral artery occlusion. The neurobehavioral functions and infarct volumes were evaluated. The presynaptic (SYN), postsynaptic (GAP-43) and cytoskeletal (MAP-2) proteins in the coronal brain samples were evaluated by immunohistochemistry and western blot analyses. The ultrastructure of the neuronal synaptic junctions in the same region were analyzed using transmission electron microscopy. Results Combination treatment of Buyang Huanwu decoction and physical exercise ameliorated the neurobehavioral deficits (p < 0.05), significantly enhanced the expression levels of SYN, GAP-43 and MAP-2 (p < 0.05), and maintained the synaptic ultrastructure. Conclusions Buyang Huanwu decoction facilitated neurorehabilitation following a cerebral ischemia insult through an improvement in synaptic plasticity. Graphical abstract The Buyang Huanwu decoction (BYHWD) combined with physical exercise (PE) attenuates synaptic disruption and promotes synaptic plasticity following cerebral ischemia (stroke).http://link.springer.com/article/10.1186/s12906-017-1680-9Buyang Huanwu decoctionCerebral ischemiaNeurorehabilitationSynaptic plasticity |
| spellingShingle | Ruihuan Pan Jun Cai Lechang Zhan Youhua Guo Run-Yue Huang Xiong Li Mingchao Zhou Dandan Xu Jie Zhan Hongxia Chen Buyang Huanwu decoction facilitates neurorehabilitation through an improvement of synaptic plasticity in cerebral ischemic rats BMC Complementary and Alternative Medicine Buyang Huanwu decoction Cerebral ischemia Neurorehabilitation Synaptic plasticity |
| title | Buyang Huanwu decoction facilitates neurorehabilitation through an improvement of synaptic plasticity in cerebral ischemic rats |
| title_full | Buyang Huanwu decoction facilitates neurorehabilitation through an improvement of synaptic plasticity in cerebral ischemic rats |
| title_fullStr | Buyang Huanwu decoction facilitates neurorehabilitation through an improvement of synaptic plasticity in cerebral ischemic rats |
| title_full_unstemmed | Buyang Huanwu decoction facilitates neurorehabilitation through an improvement of synaptic plasticity in cerebral ischemic rats |
| title_short | Buyang Huanwu decoction facilitates neurorehabilitation through an improvement of synaptic plasticity in cerebral ischemic rats |
| title_sort | buyang huanwu decoction facilitates neurorehabilitation through an improvement of synaptic plasticity in cerebral ischemic rats |
| topic | Buyang Huanwu decoction Cerebral ischemia Neurorehabilitation Synaptic plasticity |
| url | http://link.springer.com/article/10.1186/s12906-017-1680-9 |
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