The SWI/SNF complex member SMARCB1 supports lineage fidelity in kidney cancer

The SWI/SNF complex member SMARCB1 supports lineage fidelity in kidney cancer

Summary: Lineage switching can induce therapy resistance in cancer. Yet, how lineage fidelity is maintained and how it can be lost remain poorly understood. Here, we have used CRISPR-Cas9-based genetic screening to demonstrate that loss of SMARCB1, a member of the SWI/SNF chromatin remodeling comple...

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Bibliographic Details
Main Authors: Ludovic Wesolowski, Jianfeng Ge, Leticia Castillon, Debora Sesia, Anna Dyas, Shoko Hirosue, Veronica Caraffini, Anne Y. Warren, Paulo Rodrigues, Giovanni Ciriello, Saroor A. Patel, Sakari Vanharanta
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:iScience
Subjects:
Human genetics
Cellular physiology
Medical microbiology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223014372

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