Association between intracranial and extracranial atherosclerosis and white matter hyperintensities: a systematic review and meta-analysis
BackgroundWhite matter hyperintensities (WMHs) are key neuroimaging markers of cerebral small vessel diseases. This study aimed to investigate whether intracranial and extracranial atherosclerotic stenosis is associated with WMHs.MethodsFollowing a previously registered protocol (PROSPERO protocol:...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1240509/full |
| _version_ | 1797362539919572992 |
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| author | Wenyuan Zhang Fangwang Fu Zhenxiang Zhan |
| author_facet | Wenyuan Zhang Fangwang Fu Zhenxiang Zhan |
| author_sort | Wenyuan Zhang |
| collection | DOAJ |
| description | BackgroundWhite matter hyperintensities (WMHs) are key neuroimaging markers of cerebral small vessel diseases. This study aimed to investigate whether intracranial and extracranial atherosclerotic stenosis is associated with WMHs.MethodsFollowing a previously registered protocol (PROSPERO protocol: CRD42023407465), PubMed, Web of Science, and Embase were systematically searched for relevant literature published until March 2023. Cross-sectional studies examining the association between intracranial and extracranial atherosclerotic stenosis and WMHs were included. Random effects models were used to calculate the pooled estimates.ResultsTwenty-one eligible studies, including 10,841 participants, were identified. Intracranial and extracranial atherosclerotic stenosis was associated with an increased risk of WMHs (OR 1.80, 95% CI 1.25–2.57, I2 = 75%) and increased WMH volumes (SMD 0.40, 95% CI 0.18–0.63, I2 = 63%). Heterogeneity resulted from the WMHs rating method and the location. Extracranial atherosclerotic stenosis (ECAS) was significantly associated with WMHs (OR 2.10, 95% CI 1.22–3.62, I2 = 71%), but intracranial atherosclerotic stenosis (ICAS) was insignificantly associated with WMHs (OR 1.75, 95% CI 0.97–3.15, I2 = 84%). The association was stable in the subgroup analysis based on WMHs location, which included deep WMHs and periventricular WMHs.ConclusionIntracranial and extracranial atherosclerotic stenosis is associated with WMHs. This association is significant in ECAS, but attenuated in ICAS. |
| first_indexed | 2024-03-08T16:08:23Z |
| format | Article |
| id | doaj.art-62a29c6592dd4292a97472d0d3d0760f |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-08T16:08:23Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-62a29c6592dd4292a97472d0d3d0760f2024-01-08T04:30:18ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652024-01-011510.3389/fnagi.2023.12405091240509Association between intracranial and extracranial atherosclerosis and white matter hyperintensities: a systematic review and meta-analysisWenyuan Zhang0Fangwang Fu1Zhenxiang Zhan2Department of Neurology, Affiliated Yueqing Hospital, Wenzhou Medical University, Yueqing, ChinaDepartment of Neurology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, ChinaBackgroundWhite matter hyperintensities (WMHs) are key neuroimaging markers of cerebral small vessel diseases. This study aimed to investigate whether intracranial and extracranial atherosclerotic stenosis is associated with WMHs.MethodsFollowing a previously registered protocol (PROSPERO protocol: CRD42023407465), PubMed, Web of Science, and Embase were systematically searched for relevant literature published until March 2023. Cross-sectional studies examining the association between intracranial and extracranial atherosclerotic stenosis and WMHs were included. Random effects models were used to calculate the pooled estimates.ResultsTwenty-one eligible studies, including 10,841 participants, were identified. Intracranial and extracranial atherosclerotic stenosis was associated with an increased risk of WMHs (OR 1.80, 95% CI 1.25–2.57, I2 = 75%) and increased WMH volumes (SMD 0.40, 95% CI 0.18–0.63, I2 = 63%). Heterogeneity resulted from the WMHs rating method and the location. Extracranial atherosclerotic stenosis (ECAS) was significantly associated with WMHs (OR 2.10, 95% CI 1.22–3.62, I2 = 71%), but intracranial atherosclerotic stenosis (ICAS) was insignificantly associated with WMHs (OR 1.75, 95% CI 0.97–3.15, I2 = 84%). The association was stable in the subgroup analysis based on WMHs location, which included deep WMHs and periventricular WMHs.ConclusionIntracranial and extracranial atherosclerotic stenosis is associated with WMHs. This association is significant in ECAS, but attenuated in ICAS.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1240509/fullcerebral small vessel diseaseextracranial atherosclerosisintracranial atherosclerosismeta-analysiswhite matter hyperintensities |
| spellingShingle | Wenyuan Zhang Fangwang Fu Zhenxiang Zhan Association between intracranial and extracranial atherosclerosis and white matter hyperintensities: a systematic review and meta-analysis Frontiers in Aging Neuroscience cerebral small vessel disease extracranial atherosclerosis intracranial atherosclerosis meta-analysis white matter hyperintensities |
| title | Association between intracranial and extracranial atherosclerosis and white matter hyperintensities: a systematic review and meta-analysis |
| title_full | Association between intracranial and extracranial atherosclerosis and white matter hyperintensities: a systematic review and meta-analysis |
| title_fullStr | Association between intracranial and extracranial atherosclerosis and white matter hyperintensities: a systematic review and meta-analysis |
| title_full_unstemmed | Association between intracranial and extracranial atherosclerosis and white matter hyperintensities: a systematic review and meta-analysis |
| title_short | Association between intracranial and extracranial atherosclerosis and white matter hyperintensities: a systematic review and meta-analysis |
| title_sort | association between intracranial and extracranial atherosclerosis and white matter hyperintensities a systematic review and meta analysis |
| topic | cerebral small vessel disease extracranial atherosclerosis intracranial atherosclerosis meta-analysis white matter hyperintensities |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1240509/full |
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