Brain Oxygen Perfusion and Oxidative Stress Biomarkers in Fetuses with Congenital Heart Disease—A Retrospective, Case-Control Pilot Study
Fetuses with congenital heart disease (CHD) have circulatory changes that may lead to predictable blood flow disturbances that may affect normal brain development. Hypoxemia and hypoperfusion may alter the redox balance leading to oxidative stress (OS), that can be assessed measuring stable end-prod...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/2/299 |
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| author | Maria C. Escobar-Diaz Miriam Pérez-Cruz Miguel Arráez Mari-Merce Cascant-Vilaplana Abel Albiach-Delgado Julia Kuligowski Máximo Vento Narcis Masoller Maria Dolores Gómez-Roig Olga Gómez Joan Sanchez-de-Toledo Marta Camprubí-Camprubí |
| author_facet | Maria C. Escobar-Diaz Miriam Pérez-Cruz Miguel Arráez Mari-Merce Cascant-Vilaplana Abel Albiach-Delgado Julia Kuligowski Máximo Vento Narcis Masoller Maria Dolores Gómez-Roig Olga Gómez Joan Sanchez-de-Toledo Marta Camprubí-Camprubí |
| author_sort | Maria C. Escobar-Diaz |
| collection | DOAJ |
| description | Fetuses with congenital heart disease (CHD) have circulatory changes that may lead to predictable blood flow disturbances that may affect normal brain development. Hypoxemia and hypoperfusion may alter the redox balance leading to oxidative stress (OS), that can be assessed measuring stable end-products. OS biomarkers (OSB) were measured in amniotic fluid in fetuses with (<i>n</i> = 41) and without CHD (<i>n</i> = 44) and analyzed according to aortic flow, expected cyanosis after birth, and a CHD classification derived from this. Birth head circumference (HC) was used as a neurodevelopment biomarker. CHD fetuses had higher levels of ortho-Tyrosine (o-Tyr) than controls (<i>p</i> = 0.0003). There were no differences in o-Tyr levels considering aortic flow obstruction (<i>p</i> = 0.617). Fetuses with expected extreme cyanosis presented the highest levels of o-Tyr (<i>p</i> = 0.003). Among groups of CHD, fetuses without aortic obstruction and extreme cyanosis had the highest levels of o-Tyr (<i>p</i> = 0.005). CHD patients had lower HC than controls (<i>p</i> = 0.023), without correlation with OSB. Patients with HC < 10th percentile, presented high levels of o-Tyr (<i>p</i> = 0.024). Fetuses with CHD showed increased OSB and lower HC when compared to controls, especially those with expected extreme cyanosis. Our results suggest that increased levels of OSB are more influenced by the effect of low oxygenation than by aortic flow obstruction. Future studies with larger sample size are needed to further investigate the role of OSB as an early predictor of neurodevelopmental problems in CHD survivors. |
| first_indexed | 2024-03-09T22:44:30Z |
| format | Article |
| id | doaj.art-62a47127738b41e497c709b789b65a82 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T22:44:30Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-62a47127738b41e497c709b789b65a822023-11-23T18:31:35ZengMDPI AGAntioxidants2076-39212022-01-0111229910.3390/antiox11020299Brain Oxygen Perfusion and Oxidative Stress Biomarkers in Fetuses with Congenital Heart Disease—A Retrospective, Case-Control Pilot StudyMaria C. Escobar-Diaz0Miriam Pérez-Cruz1Miguel Arráez2Mari-Merce Cascant-Vilaplana3Abel Albiach-Delgado4Julia Kuligowski5Máximo Vento6Narcis Masoller7Maria Dolores Gómez-Roig8Olga Gómez9Joan Sanchez-de-Toledo10Marta Camprubí-Camprubí11Pediatric Cardiology Department, Sant Joan de Déu Hospital, 08950 Barcelona, SpainSant Joan de Deu Research Institute, 08950 Barcelona, SpainSant Joan de Deu Research Institute, 08950 Barcelona, SpainNeonatal Research Group, Health Research Institute La Fe, 46026 Valencia, SpainNeonatal Research Group, Health Research Institute La Fe, 46026 Valencia, SpainNeonatal Research Group, Health Research Institute La Fe, 46026 Valencia, SpainNeonatal Research Group, Health Research Institute La Fe, 46026 Valencia, SpainBCNatal-Barcelona Center for Maternal Fetal and Neonatal Medicine, Hospital Clínic, Sant Joan de Déu Hospital, 08950 Barcelona, SpainSant Joan de Deu Research Institute, 08950 Barcelona, SpainBCNatal-Barcelona Center for Maternal Fetal and Neonatal Medicine, Hospital Clínic, Sant Joan de Déu Hospital, 08950 Barcelona, SpainPediatric Cardiology Department, Sant Joan de Déu Hospital, 08950 Barcelona, SpainSant Joan de Deu Research Institute, 08950 Barcelona, SpainFetuses with congenital heart disease (CHD) have circulatory changes that may lead to predictable blood flow disturbances that may affect normal brain development. Hypoxemia and hypoperfusion may alter the redox balance leading to oxidative stress (OS), that can be assessed measuring stable end-products. OS biomarkers (OSB) were measured in amniotic fluid in fetuses with (<i>n</i> = 41) and without CHD (<i>n</i> = 44) and analyzed according to aortic flow, expected cyanosis after birth, and a CHD classification derived from this. Birth head circumference (HC) was used as a neurodevelopment biomarker. CHD fetuses had higher levels of ortho-Tyrosine (o-Tyr) than controls (<i>p</i> = 0.0003). There were no differences in o-Tyr levels considering aortic flow obstruction (<i>p</i> = 0.617). Fetuses with expected extreme cyanosis presented the highest levels of o-Tyr (<i>p</i> = 0.003). Among groups of CHD, fetuses without aortic obstruction and extreme cyanosis had the highest levels of o-Tyr (<i>p</i> = 0.005). CHD patients had lower HC than controls (<i>p</i> = 0.023), without correlation with OSB. Patients with HC < 10th percentile, presented high levels of o-Tyr (<i>p</i> = 0.024). Fetuses with CHD showed increased OSB and lower HC when compared to controls, especially those with expected extreme cyanosis. Our results suggest that increased levels of OSB are more influenced by the effect of low oxygenation than by aortic flow obstruction. Future studies with larger sample size are needed to further investigate the role of OSB as an early predictor of neurodevelopmental problems in CHD survivors.https://www.mdpi.com/2076-3921/11/2/299congenital heart diseasehypoxiabrain perfusionreactive oxygen speciesortho-Tyrosineoxidative stress |
| spellingShingle | Maria C. Escobar-Diaz Miriam Pérez-Cruz Miguel Arráez Mari-Merce Cascant-Vilaplana Abel Albiach-Delgado Julia Kuligowski Máximo Vento Narcis Masoller Maria Dolores Gómez-Roig Olga Gómez Joan Sanchez-de-Toledo Marta Camprubí-Camprubí Brain Oxygen Perfusion and Oxidative Stress Biomarkers in Fetuses with Congenital Heart Disease—A Retrospective, Case-Control Pilot Study Antioxidants congenital heart disease hypoxia brain perfusion reactive oxygen species ortho-Tyrosine oxidative stress |
| title | Brain Oxygen Perfusion and Oxidative Stress Biomarkers in Fetuses with Congenital Heart Disease—A Retrospective, Case-Control Pilot Study |
| title_full | Brain Oxygen Perfusion and Oxidative Stress Biomarkers in Fetuses with Congenital Heart Disease—A Retrospective, Case-Control Pilot Study |
| title_fullStr | Brain Oxygen Perfusion and Oxidative Stress Biomarkers in Fetuses with Congenital Heart Disease—A Retrospective, Case-Control Pilot Study |
| title_full_unstemmed | Brain Oxygen Perfusion and Oxidative Stress Biomarkers in Fetuses with Congenital Heart Disease—A Retrospective, Case-Control Pilot Study |
| title_short | Brain Oxygen Perfusion and Oxidative Stress Biomarkers in Fetuses with Congenital Heart Disease—A Retrospective, Case-Control Pilot Study |
| title_sort | brain oxygen perfusion and oxidative stress biomarkers in fetuses with congenital heart disease a retrospective case control pilot study |
| topic | congenital heart disease hypoxia brain perfusion reactive oxygen species ortho-Tyrosine oxidative stress |
| url | https://www.mdpi.com/2076-3921/11/2/299 |
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