Pulmonary Toxicity and Proteomic Analysis in Bronchoalveolar Lavage Fluids and Lungs of Rats Exposed to Copper Oxide Nanoparticles

Pulmonary Toxicity and Proteomic Analysis in Bronchoalveolar Lavage Fluids and Lungs of Rats Exposed to Copper Oxide Nanoparticles

Copper oxide nanoparticles (CuO NPs) were intratracheally instilled into lungs at concentrations of 0, 0.15, and 1.5 mg/kg bodyweight to 7-week-old Sprague–Dawley rats. The cytotoxicity, immunotoxicity, and oxidative stress were evaluated, followed by proteomic analysis of bronchoalveolar lavage flu...

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Bibliographic Details
Main Authors: Jung-Taek Kwon, Yoonjin Kim, Seonyoung Choi, Byung-ll Yoon, Hyun-Sook Kim, Ilseob Shim, Donggeun Sul
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
bronchoalveolar lavage fluid
copper oxide
nanoparticles
proteomics
rat lung
Online Access:https://www.mdpi.com/1422-0067/23/21/13265

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