Synergistic treatment strategy: combining CAR-NK cell therapy and radiotherapy to combat solid tumors
Immunotherapy, notably chimeric antigen receptor (CAR) modified natural killer (NK) cell therapy, has shown exciting promise in the treatment of hematologic malignancies due to its unique advantages including fewer side effects, diverse activation mechanisms, and wide availability. However, CAR-NK c...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1298683/full |
| _version_ | 1827583478722461696 |
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| author | Jie He Jie He Yushan Yan Yushan Yan Jun Zhang Zhiming Wei Huashun Li Ligang Xing Ligang Xing |
| author_facet | Jie He Jie He Yushan Yan Yushan Yan Jun Zhang Zhiming Wei Huashun Li Ligang Xing Ligang Xing |
| author_sort | Jie He |
| collection | DOAJ |
| description | Immunotherapy, notably chimeric antigen receptor (CAR) modified natural killer (NK) cell therapy, has shown exciting promise in the treatment of hematologic malignancies due to its unique advantages including fewer side effects, diverse activation mechanisms, and wide availability. However, CAR-NK cell therapies have demonstrated limited efficacy against solid tumors, primarily due to challenges posed by the solid tumor microenvironment. In contrast, radiotherapy, a well-established treatment modality, has been proven to modulate the tumor microenvironment and facilitate immune cell infiltration. With these observations, we hypothesize that a novel therapeutic strategy integrating CAR-NK cell therapy with radiotherapy could enhance the ability to treat solid tumors. This hypothesis aims to address the obstacles CAR-NK cell therapies face within the solid tumor microenvironment and explore the potential efficacy of their combination with radiotherapy. By capitalizing on the synergistic advantages of CAR-NK cell therapy and radiotherapy, we posit that this could lead to improved prognoses for patients with solid tumors. |
| first_indexed | 2024-03-08T23:07:23Z |
| format | Article |
| id | doaj.art-62a7026fe85447baa1a3470b6f09b8f5 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T23:07:23Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-62a7026fe85447baa1a3470b6f09b8f52023-12-15T10:35:54ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-12-011410.3389/fimmu.2023.12986831298683Synergistic treatment strategy: combining CAR-NK cell therapy and radiotherapy to combat solid tumorsJie He0Jie He1Yushan Yan2Yushan Yan3Jun Zhang4Zhiming Wei5Huashun Li6Ligang Xing7Ligang Xing8Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaShandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaShandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaAsclepius (Soochow) Technology Company Group, Suzhou, Jiangsu, ChinaAsclepius (Soochow) Technology Company Group, Suzhou, Jiangsu, ChinaAsclepius (Soochow) Technology Company Group, Suzhou, Jiangsu, ChinaDepartment of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaShandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaImmunotherapy, notably chimeric antigen receptor (CAR) modified natural killer (NK) cell therapy, has shown exciting promise in the treatment of hematologic malignancies due to its unique advantages including fewer side effects, diverse activation mechanisms, and wide availability. However, CAR-NK cell therapies have demonstrated limited efficacy against solid tumors, primarily due to challenges posed by the solid tumor microenvironment. In contrast, radiotherapy, a well-established treatment modality, has been proven to modulate the tumor microenvironment and facilitate immune cell infiltration. With these observations, we hypothesize that a novel therapeutic strategy integrating CAR-NK cell therapy with radiotherapy could enhance the ability to treat solid tumors. This hypothesis aims to address the obstacles CAR-NK cell therapies face within the solid tumor microenvironment and explore the potential efficacy of their combination with radiotherapy. By capitalizing on the synergistic advantages of CAR-NK cell therapy and radiotherapy, we posit that this could lead to improved prognoses for patients with solid tumors.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1298683/fullchimeric antigen receptorradiotherapysolid tumorstumor microenvironmentnatural killer cells |
| spellingShingle | Jie He Jie He Yushan Yan Yushan Yan Jun Zhang Zhiming Wei Huashun Li Ligang Xing Ligang Xing Synergistic treatment strategy: combining CAR-NK cell therapy and radiotherapy to combat solid tumors Frontiers in Immunology chimeric antigen receptor radiotherapy solid tumors tumor microenvironment natural killer cells |
| title | Synergistic treatment strategy: combining CAR-NK cell therapy and radiotherapy to combat solid tumors |
| title_full | Synergistic treatment strategy: combining CAR-NK cell therapy and radiotherapy to combat solid tumors |
| title_fullStr | Synergistic treatment strategy: combining CAR-NK cell therapy and radiotherapy to combat solid tumors |
| title_full_unstemmed | Synergistic treatment strategy: combining CAR-NK cell therapy and radiotherapy to combat solid tumors |
| title_short | Synergistic treatment strategy: combining CAR-NK cell therapy and radiotherapy to combat solid tumors |
| title_sort | synergistic treatment strategy combining car nk cell therapy and radiotherapy to combat solid tumors |
| topic | chimeric antigen receptor radiotherapy solid tumors tumor microenvironment natural killer cells |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1298683/full |
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