Antithrombotic Effects of the Novel Small-Molecule Factor XIa Inhibitor Milvexian in a Rabbit Arteriovenous Shunt Model of Venous Thrombosis

Antithrombotic Effects of the Novel Small-Molecule Factor XIa Inhibitor Milvexian in a Rabbit Arteriovenous Shunt Model of Venous Thrombosis

Abstract Background Factor XIa (FXIa) is an emerging therapeutic target, and FXIa inhibition is a promising mechanism to improve therapeutic index over current anticoagulants. Milvexian (BMS-986177/JNJ-70033093) is an oral small-molecule FXIa inhibitor....

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Bibliographic Details
Main Authors: Xinkang Wang, Qiu Li, Fuyong Du, Neetu Shukla, Andrea R. Nawrocki, Madhu Chintala
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2023-04-01
Series:TH Open
Subjects:
anticoagulants
factor xi
thrombosis
models
animal
pharmacology
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/a-2061-3311

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