Unraveling the prognostic significance of RGS gene family in gastric cancer and the potential implication of RGS4 in regulating tumor-infiltrating fibroblast
Regulator of G-protein signaling (RGS) proteins are regulators of signal transduction mediated by G protein-coupled receptors (GPCRs). Current studies have shown that some molecules in the RGS gene family are related to the occurrence, development and poor prognosis of malignant tumors. However, the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2024.1158852/full |
| _version_ | 1797203097580208128 |
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| author | Yalan Yang Siyuan Xing Xi Luo Lulu Guan Yao Lu Yiting Wang Feng Wang |
| author_facet | Yalan Yang Siyuan Xing Xi Luo Lulu Guan Yao Lu Yiting Wang Feng Wang |
| author_sort | Yalan Yang |
| collection | DOAJ |
| description | Regulator of G-protein signaling (RGS) proteins are regulators of signal transduction mediated by G protein-coupled receptors (GPCRs). Current studies have shown that some molecules in the RGS gene family are related to the occurrence, development and poor prognosis of malignant tumors. However, the RGS gene family has been rarely studied in gastric cancer. In this study, we explored the mutation and expression profile of RGS gene family in gastric cancer, and evaluated the prognostic value of RGS expression. Then we established a prognostic model based on RGS gene family and performed functional analysis. Further studies showed that RGS4, as an independent prognostic predictor, may play an important role in regulating fibroblasts in the immune microenvironment. In conclusion, this study explores the value of RGS gene family in gastric cancer, which is of great significance for predicting the prognosis and guiding the treatment of gastric cancer. |
| first_indexed | 2024-04-24T08:13:55Z |
| format | Article |
| id | doaj.art-62a78a9da7fd410da3f895513315b1e7 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-24T08:13:55Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-62a78a9da7fd410da3f895513315b1e72024-04-17T04:39:25ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2024-04-011110.3389/fmolb.2024.11588521158852Unraveling the prognostic significance of RGS gene family in gastric cancer and the potential implication of RGS4 in regulating tumor-infiltrating fibroblastYalan YangSiyuan XingXi LuoLulu GuanYao LuYiting WangFeng WangRegulator of G-protein signaling (RGS) proteins are regulators of signal transduction mediated by G protein-coupled receptors (GPCRs). Current studies have shown that some molecules in the RGS gene family are related to the occurrence, development and poor prognosis of malignant tumors. However, the RGS gene family has been rarely studied in gastric cancer. In this study, we explored the mutation and expression profile of RGS gene family in gastric cancer, and evaluated the prognostic value of RGS expression. Then we established a prognostic model based on RGS gene family and performed functional analysis. Further studies showed that RGS4, as an independent prognostic predictor, may play an important role in regulating fibroblasts in the immune microenvironment. In conclusion, this study explores the value of RGS gene family in gastric cancer, which is of great significance for predicting the prognosis and guiding the treatment of gastric cancer.https://www.frontiersin.org/articles/10.3389/fmolb.2024.1158852/fullRGS4gastric cancerprognosisfibroblastimmune infiltration |
| spellingShingle | Yalan Yang Siyuan Xing Xi Luo Lulu Guan Yao Lu Yiting Wang Feng Wang Unraveling the prognostic significance of RGS gene family in gastric cancer and the potential implication of RGS4 in regulating tumor-infiltrating fibroblast Frontiers in Molecular Biosciences RGS4 gastric cancer prognosis fibroblast immune infiltration |
| title | Unraveling the prognostic significance of RGS gene family in gastric cancer and the potential implication of RGS4 in regulating tumor-infiltrating fibroblast |
| title_full | Unraveling the prognostic significance of RGS gene family in gastric cancer and the potential implication of RGS4 in regulating tumor-infiltrating fibroblast |
| title_fullStr | Unraveling the prognostic significance of RGS gene family in gastric cancer and the potential implication of RGS4 in regulating tumor-infiltrating fibroblast |
| title_full_unstemmed | Unraveling the prognostic significance of RGS gene family in gastric cancer and the potential implication of RGS4 in regulating tumor-infiltrating fibroblast |
| title_short | Unraveling the prognostic significance of RGS gene family in gastric cancer and the potential implication of RGS4 in regulating tumor-infiltrating fibroblast |
| title_sort | unraveling the prognostic significance of rgs gene family in gastric cancer and the potential implication of rgs4 in regulating tumor infiltrating fibroblast |
| topic | RGS4 gastric cancer prognosis fibroblast immune infiltration |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2024.1158852/full |
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