Beyond Borders: Investigating the Mysteries of Cacipacoré, a Lesser-Studied Arbovirus in Brazil
Cacipacoré virus (CPCV) was discovered in 1977 deep in the Amazon rainforest from the blood of a black-faced ant thrush (<i>Formicarius analis</i>). As a member of the family Flaviviridae and genus orthoflavivirus, CPCV’s intricate ecological association with vectors and hosts raises pro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/16/3/336 |
| _version_ | 1797239094828335104 |
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| author | Marielena V. Saivish Maurício L. Nogueira Shannan L. Rossi Nikos Vasilakis |
| author_facet | Marielena V. Saivish Maurício L. Nogueira Shannan L. Rossi Nikos Vasilakis |
| author_sort | Marielena V. Saivish |
| collection | DOAJ |
| description | Cacipacoré virus (CPCV) was discovered in 1977 deep in the Amazon rainforest from the blood of a black-faced ant thrush (<i>Formicarius analis</i>). As a member of the family Flaviviridae and genus orthoflavivirus, CPCV’s intricate ecological association with vectors and hosts raises profound questions. CPCV’s transmission cycle may involve birds, rodents, equids, bovines, marsupials, non-human primates, and bats as potential vertebrate hosts, whereas <i>Culex</i> and <i>Aedes</i> spp. mosquitoes have been implicated as potential vectors of transmission. The virus’ isolation across diverse biomes, including urban settings, suggests its adaptability, as well as presents challenges for its accurate diagnosis, and thus its impact on veterinary and human health. With no specific treatment or vaccine, its prevention hinges on traditional arbovirus control measures. Here, we provide an overview of its ecology, transmission cycles, epidemiology, pathogenesis, and prevention, aiming at improving our ability to better understand this neglected arbovirus. |
| first_indexed | 2024-04-24T17:46:05Z |
| format | Article |
| id | doaj.art-62a8173475974f779d47b93a57f116de |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-04-24T17:46:05Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-62a8173475974f779d47b93a57f116de2024-03-27T14:07:35ZengMDPI AGViruses1999-49152024-02-0116333610.3390/v16030336Beyond Borders: Investigating the Mysteries of Cacipacoré, a Lesser-Studied Arbovirus in BrazilMarielena V. Saivish0Maurício L. Nogueira1Shannan L. Rossi2Nikos Vasilakis3Laboratórios de Pesquisas em Virologia, Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias, Faculdade de Medicina de São José do Rio Preto, Sao Jose do Rio Preto 15090-000, SP, BrazilLaboratórios de Pesquisas em Virologia, Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias, Faculdade de Medicina de São José do Rio Preto, Sao Jose do Rio Preto 15090-000, SP, BrazilDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USADepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USACacipacoré virus (CPCV) was discovered in 1977 deep in the Amazon rainforest from the blood of a black-faced ant thrush (<i>Formicarius analis</i>). As a member of the family Flaviviridae and genus orthoflavivirus, CPCV’s intricate ecological association with vectors and hosts raises profound questions. CPCV’s transmission cycle may involve birds, rodents, equids, bovines, marsupials, non-human primates, and bats as potential vertebrate hosts, whereas <i>Culex</i> and <i>Aedes</i> spp. mosquitoes have been implicated as potential vectors of transmission. The virus’ isolation across diverse biomes, including urban settings, suggests its adaptability, as well as presents challenges for its accurate diagnosis, and thus its impact on veterinary and human health. With no specific treatment or vaccine, its prevention hinges on traditional arbovirus control measures. Here, we provide an overview of its ecology, transmission cycles, epidemiology, pathogenesis, and prevention, aiming at improving our ability to better understand this neglected arbovirus.https://www.mdpi.com/1999-4915/16/3/336<i>Orthoflavivirus</i>transmission cyclesepidemiologypathogenesisclinical manifestations |
| spellingShingle | Marielena V. Saivish Maurício L. Nogueira Shannan L. Rossi Nikos Vasilakis Beyond Borders: Investigating the Mysteries of Cacipacoré, a Lesser-Studied Arbovirus in Brazil Viruses <i>Orthoflavivirus</i> transmission cycles epidemiology pathogenesis clinical manifestations |
| title | Beyond Borders: Investigating the Mysteries of Cacipacoré, a Lesser-Studied Arbovirus in Brazil |
| title_full | Beyond Borders: Investigating the Mysteries of Cacipacoré, a Lesser-Studied Arbovirus in Brazil |
| title_fullStr | Beyond Borders: Investigating the Mysteries of Cacipacoré, a Lesser-Studied Arbovirus in Brazil |
| title_full_unstemmed | Beyond Borders: Investigating the Mysteries of Cacipacoré, a Lesser-Studied Arbovirus in Brazil |
| title_short | Beyond Borders: Investigating the Mysteries of Cacipacoré, a Lesser-Studied Arbovirus in Brazil |
| title_sort | beyond borders investigating the mysteries of cacipacore a lesser studied arbovirus in brazil |
| topic | <i>Orthoflavivirus</i> transmission cycles epidemiology pathogenesis clinical manifestations |
| url | https://www.mdpi.com/1999-4915/16/3/336 |
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