BINARY MICELLES (E45S8/F127) FOR QUERCETIN AND GRISEOFULVIN SOLUBILISATION
Micelles have aroused interest due to their ability to assist in the transport of poorly soluble drugs. In this study the mixture of copolymers F127/E45S8 in different proportions (F/ES 30/70, 50/50 and 70/30) was performed to improve the bioavailability of griseofulvin and quercetin. The results of...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2020-10-01
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| Series: | Química Nova |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000801011&tlng=en |
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| author | Karen P. S. Lopes Igor M. Cavalcante Raquel F. da Silva Débora H. A. de Brito Lillian M. U. D. Fechine Denise R. Moreira Ícaro G. P. Vieira Francisco Vinícius Clemente S. Azul Luzia K. A. M. Leal Maria E. N. P. Ribeiro Nágila M. P. S. Ricardo |
| author_facet | Karen P. S. Lopes Igor M. Cavalcante Raquel F. da Silva Débora H. A. de Brito Lillian M. U. D. Fechine Denise R. Moreira Ícaro G. P. Vieira Francisco Vinícius Clemente S. Azul Luzia K. A. M. Leal Maria E. N. P. Ribeiro Nágila M. P. S. Ricardo |
| author_sort | Karen P. S. Lopes |
| collection | DOAJ |
| description | Micelles have aroused interest due to their ability to assist in the transport of poorly soluble drugs. In this study the mixture of copolymers F127/E45S8 in different proportions (F/ES 30/70, 50/50 and 70/30) was performed to improve the bioavailability of griseofulvin and quercetin. The results of cytotoxicity (MTT assay) revealed that the copolymers F127 and E45S8 had considerable biocompatibility and did not affect the metabolism of human neutrophils. The binary systems were also evaluated by critical micellar concentration (CMC) and thermoresponsive behavior. The CMC values were intermediate to those of the isolated copolymers. The systems maintained the thermoresponsive properties present in F127 making the systems interesting for subcutaneous administration. The systems presented small size, an average range in size from 17 to 38 nm, and the samples prepared with higher hydrophobic proportion presented more uniform sizes. Results suggest stability and the increasing of the nanosystems circulation time. The F/ES 30/70 system has polydispersity smaller than 0.1 and showed an increase of 129 times for quercetin solubility. Thus, it is possible to consider F127/E45S8 micelles as potential nanosystems for poorly soluble drug delivery. |
| first_indexed | 2024-12-24T01:59:17Z |
| format | Article |
| id | doaj.art-62a8472b0eda4987a2a89d5fc9679f97 |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-12-24T01:59:17Z |
| publishDate | 2020-10-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-62a8472b0eda4987a2a89d5fc9679f972022-12-21T17:21:29ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642020-10-014381011101610.21577/0100-4042.20170570BINARY MICELLES (E45S8/F127) FOR QUERCETIN AND GRISEOFULVIN SOLUBILISATIONKaren P. S. LopesIgor M. CavalcanteRaquel F. da SilvaDébora H. A. de BritoLillian M. U. D. FechineDenise R. MoreiraÍcaro G. P. VieiraFrancisco Vinícius Clemente S. AzulLuzia K. A. M. LealMaria E. N. P. Ribeirohttps://orcid.org/0000-0001-6896-7179Nágila M. P. S. RicardoMicelles have aroused interest due to their ability to assist in the transport of poorly soluble drugs. In this study the mixture of copolymers F127/E45S8 in different proportions (F/ES 30/70, 50/50 and 70/30) was performed to improve the bioavailability of griseofulvin and quercetin. The results of cytotoxicity (MTT assay) revealed that the copolymers F127 and E45S8 had considerable biocompatibility and did not affect the metabolism of human neutrophils. The binary systems were also evaluated by critical micellar concentration (CMC) and thermoresponsive behavior. The CMC values were intermediate to those of the isolated copolymers. The systems maintained the thermoresponsive properties present in F127 making the systems interesting for subcutaneous administration. The systems presented small size, an average range in size from 17 to 38 nm, and the samples prepared with higher hydrophobic proportion presented more uniform sizes. Results suggest stability and the increasing of the nanosystems circulation time. The F/ES 30/70 system has polydispersity smaller than 0.1 and showed an increase of 129 times for quercetin solubility. Thus, it is possible to consider F127/E45S8 micelles as potential nanosystems for poorly soluble drug delivery.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000801011&tlng=enAtomic Force Microscopydrug solubilisationcytotoxicity assaytube inversion |
| spellingShingle | Karen P. S. Lopes Igor M. Cavalcante Raquel F. da Silva Débora H. A. de Brito Lillian M. U. D. Fechine Denise R. Moreira Ícaro G. P. Vieira Francisco Vinícius Clemente S. Azul Luzia K. A. M. Leal Maria E. N. P. Ribeiro Nágila M. P. S. Ricardo BINARY MICELLES (E45S8/F127) FOR QUERCETIN AND GRISEOFULVIN SOLUBILISATION Química Nova Atomic Force Microscopy drug solubilisation cytotoxicity assay tube inversion |
| title | BINARY MICELLES (E45S8/F127) FOR QUERCETIN AND GRISEOFULVIN SOLUBILISATION |
| title_full | BINARY MICELLES (E45S8/F127) FOR QUERCETIN AND GRISEOFULVIN SOLUBILISATION |
| title_fullStr | BINARY MICELLES (E45S8/F127) FOR QUERCETIN AND GRISEOFULVIN SOLUBILISATION |
| title_full_unstemmed | BINARY MICELLES (E45S8/F127) FOR QUERCETIN AND GRISEOFULVIN SOLUBILISATION |
| title_short | BINARY MICELLES (E45S8/F127) FOR QUERCETIN AND GRISEOFULVIN SOLUBILISATION |
| title_sort | binary micelles e45s8 f127 for quercetin and griseofulvin solubilisation |
| topic | Atomic Force Microscopy drug solubilisation cytotoxicity assay tube inversion |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000801011&tlng=en |
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