Central nervous system effects of TAK-653, an investigational alpha-amino-3-hydroxy-5-methyl-4-isoxazole receptor (AMPAR) positive allosteric modulator in healthy volunteers

Central nervous system effects of TAK-653, an investigational alpha-amino-3-hydroxy-5-methyl-4-isoxazole receptor (AMPAR) positive allosteric modulator in healthy volunteers

Abstract TAK-653 is a novel AMPA receptor positive allosteric modulator in clinical development for the treatment of major depressive disorder (MDD). This study aimed to measure the functional pharmacodynamic central nervous system (CNS) effects of TAK-653. A randomised, double-blind, placebo-contro...

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Bibliographic Details
Main Authors: Francis Dijkstra, Patricio O’Donnell, Erica Klaassen, Derek Buhl, Mahnaz Asgharnejad, Laura Rosen, Rob Zuiker, Joop van Gerven, Gabriël Jacobs
Format: Article
Language:English
Published: Nature Publishing Group 2022-09-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-022-02148-w

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https://doi.org/10.1038/s41398-022-02148-w

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