Cell-Mediated Delivery of Brain-Derived Neurotrophic Factor Enhances Dopamine Levels in an Mpp+ Rat Model of Substantia Nigra Degeneration

Cell-Mediated Delivery of Brain-Derived Neurotrophic Factor Enhances Dopamine Levels in an Mpp+ Rat Model of Substantia Nigra Degeneration

Brain-derived neurotrophic factor (BDNF) promotes the survival of fetal mesencephalic dopaminergic cells and protects dopaminergic neurons against the toxicity of MPP+ in vitro. Supranigral implantation of fibroblasts genetically engineered to secrete BDNF attenuates the loss of substantia nigra par...

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Bibliographic Details
Main Authors:	Wendy R. Galpern, David M. Frim, Stephen B. Tatter, C. Anthony Altar, M. Flint Beal, Ole Isacson
Format:	Article
Language:	English
Published:	SAGE Publishing 1996-03-01
Series:	Cell Transplantation
Online Access:	https://doi.org/10.1177/096368979600500211

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