YpfΦ : a filamentous phage acquired by Yersinia pestis
Yersinia pestis, the plague bacillus, has an exceptional pathogenicity for humans. The plague bacillus emerged very recently (≈3,000 years ago) from the enteropathogen Y. pseudotuberculosis. Early after its emergence, Y. pestis became infected by a filamentous phage named YpfΦ. During the microevolu...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-12-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00701/full |
| _version_ | 1819128485975687168 |
|---|---|
| author | Anne eDerbise Elisabeth eCarniel |
| author_facet | Anne eDerbise Elisabeth eCarniel |
| author_sort | Anne eDerbise |
| collection | DOAJ |
| description | Yersinia pestis, the plague bacillus, has an exceptional pathogenicity for humans. The plague bacillus emerged very recently (≈3,000 years ago) from the enteropathogen Y. pseudotuberculosis. Early after its emergence, Y. pestis became infected by a filamentous phage named YpfΦ. During the microevolution of the plague bacillus, the phage remained in the various lineages as an unstable extrachromosomal element. However, in the sub branch that caused the third plague pandemic, YpfΦ integrated itself into the bacterial chromosome to become a stable prophage. The genome of this phage has the same genetic organization as that of other filamentous phages such as the V. cholerae CTXΦ phage, and shares high sequence identity with the CUS-1 filamentous phage of a high-virulence E. coli K1 clone. In addition to genes involved in phage physiology, YpfΦ carries at each extremity of its genome two open reading frames with no predicted functions. This filamentous phage confers some selective properties to Y. pestis during the infectious process, which may explain why it was conserved during Y. pestis microevolution, despite its instability as an extrachromosomal element in most branches. |
| first_indexed | 2024-12-22T08:28:35Z |
| format | Article |
| id | doaj.art-62b0521fa9ae4291b7094bf444a159e5 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-22T08:28:35Z |
| publishDate | 2014-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-62b0521fa9ae4291b7094bf444a159e52022-12-21T18:32:33ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2014-12-01510.3389/fmicb.2014.00701120015YpfΦ : a filamentous phage acquired by Yersinia pestisAnne eDerbise0Elisabeth eCarniel1Pasteur InstitutPasteur InstitutYersinia pestis, the plague bacillus, has an exceptional pathogenicity for humans. The plague bacillus emerged very recently (≈3,000 years ago) from the enteropathogen Y. pseudotuberculosis. Early after its emergence, Y. pestis became infected by a filamentous phage named YpfΦ. During the microevolution of the plague bacillus, the phage remained in the various lineages as an unstable extrachromosomal element. However, in the sub branch that caused the third plague pandemic, YpfΦ integrated itself into the bacterial chromosome to become a stable prophage. The genome of this phage has the same genetic organization as that of other filamentous phages such as the V. cholerae CTXΦ phage, and shares high sequence identity with the CUS-1 filamentous phage of a high-virulence E. coli K1 clone. In addition to genes involved in phage physiology, YpfΦ carries at each extremity of its genome two open reading frames with no predicted functions. This filamentous phage confers some selective properties to Y. pestis during the infectious process, which may explain why it was conserved during Y. pestis microevolution, despite its instability as an extrachromosomal element in most branches.http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00701/fullPlagueYersinia pestisfilamentous bacteriophageYpfΦpathogene emergence |
| spellingShingle | Anne eDerbise Elisabeth eCarniel YpfΦ : a filamentous phage acquired by Yersinia pestis Frontiers in Microbiology Plague Yersinia pestis filamentous bacteriophage YpfΦ pathogene emergence |
| title | YpfΦ : a filamentous phage acquired by Yersinia pestis |
| title_full | YpfΦ : a filamentous phage acquired by Yersinia pestis |
| title_fullStr | YpfΦ : a filamentous phage acquired by Yersinia pestis |
| title_full_unstemmed | YpfΦ : a filamentous phage acquired by Yersinia pestis |
| title_short | YpfΦ : a filamentous phage acquired by Yersinia pestis |
| title_sort | ypfφ a filamentous phage acquired by yersinia pestis |
| topic | Plague Yersinia pestis filamentous bacteriophage YpfΦ pathogene emergence |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00701/full |
| work_keys_str_mv | AT anneederbise ypfphafilamentousphageacquiredbyyersiniapestis AT elisabethecarniel ypfphafilamentousphageacquiredbyyersiniapestis |