Comparing Different Diagnostic Guidelines for Gestational Diabetes Mellitus in Relation to Birthweight in Sri Lankan Women
Introduction: While the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria is widely adopted in many countries, clinicians have questioned the applicability of these diagnostic thresholds for different races/ethnicities. We first compared the prevalence of gestational...
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2018.00682/full |
| _version_ | 1811221809984438272 |
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| author | Thiran Dias Shahul Hameed Mohamed Siraj Izzuddin Mohamed Aris Ling-Jun Li Ling-Jun Li Ling-Jun Li Kok Hian Tan Kok Hian Tan |
| author_facet | Thiran Dias Shahul Hameed Mohamed Siraj Izzuddin Mohamed Aris Ling-Jun Li Ling-Jun Li Ling-Jun Li Kok Hian Tan Kok Hian Tan |
| author_sort | Thiran Dias |
| collection | DOAJ |
| description | Introduction: While the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria is widely adopted in many countries, clinicians have questioned the applicability of these diagnostic thresholds for different races/ethnicities. We first compared the prevalence of gestational diabetes mellitus (GDM) diagnosed with different criteria including IADPSG, World Health Organization (WHO) 1999 and Sri Lankan national guidelines, and subsequently related individual guidelines-specific GDM prevalence to offspring birthweight in Sri Lanka.Materials and Methods: We retrospectively collected data on singleton pregnancies (n = 795) from two tertiary hospitals in Sri Lanka. We applied three diagnostic guidelines to define GDM, namely IADPSG criteria, the Sri Lankan national and WHO 1999 guidelines. We calculated the age- and first booking BMI-adjusted prevalence rates of GDM and assessed the association of GDM (using each guideline) with birthweight.Results: The age- and first booking BMI-adjusted GDM prevalence rates were 31.2, 28.0, and 13.1% for IADPSG criteria, Sri Lankan national and WHO 1999 guidelines, respectively. The IADPSG criteria identified 90 distinctive GDM cases at a lower cut-off of fasting glucose (from 5.1 to 5.5 mmol/L) while Sri Lankan national guideline identified 15 distinctive GDM cases at a lower cut-off for 2-h glucose (from 7.8 to 8.4 mmol/L). After adjusting for age, GDM diagnosed by IADPSG criteria was associated with higher birthweight [90.8 g, 95% CI: 10.8, 170.9], while the associations for GDM diagnosed either by Sri Lankan national or WHO 1999 guidelines were not significant.Conclusion: Adopting the IADPSG criteria for diagnosing GDM may be important in Sri Lankan pregnant population. |
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| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T08:06:36Z |
| publishDate | 2018-11-01 |
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| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-62b07d7a3bde4e33bcb2ee7f88cac7932022-12-22T03:41:08ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922018-11-01910.3389/fendo.2018.00682408802Comparing Different Diagnostic Guidelines for Gestational Diabetes Mellitus in Relation to Birthweight in Sri Lankan WomenThiran Dias0Shahul Hameed Mohamed Siraj1Izzuddin Mohamed Aris2Ling-Jun Li3Ling-Jun Li4Ling-Jun Li5Kok Hian Tan6Kok Hian Tan7Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Colombo, Colombo, Sri LankaDepartment of Obstetrics and Gynaecology, Teaching Hospital, Batticaloa, Sri LankaDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, United StatesDivision of O&G, KK Women's and Children's Hospital, Singapore, SingaporeO&G Academic Clinical Programme (ACP), Duke-NUS Medical School, Singapore, SingaporeSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, SingaporeDivision of O&G, KK Women's and Children's Hospital, Singapore, SingaporeO&G Academic Clinical Programme (ACP), Duke-NUS Medical School, Singapore, SingaporeIntroduction: While the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria is widely adopted in many countries, clinicians have questioned the applicability of these diagnostic thresholds for different races/ethnicities. We first compared the prevalence of gestational diabetes mellitus (GDM) diagnosed with different criteria including IADPSG, World Health Organization (WHO) 1999 and Sri Lankan national guidelines, and subsequently related individual guidelines-specific GDM prevalence to offspring birthweight in Sri Lanka.Materials and Methods: We retrospectively collected data on singleton pregnancies (n = 795) from two tertiary hospitals in Sri Lanka. We applied three diagnostic guidelines to define GDM, namely IADPSG criteria, the Sri Lankan national and WHO 1999 guidelines. We calculated the age- and first booking BMI-adjusted prevalence rates of GDM and assessed the association of GDM (using each guideline) with birthweight.Results: The age- and first booking BMI-adjusted GDM prevalence rates were 31.2, 28.0, and 13.1% for IADPSG criteria, Sri Lankan national and WHO 1999 guidelines, respectively. The IADPSG criteria identified 90 distinctive GDM cases at a lower cut-off of fasting glucose (from 5.1 to 5.5 mmol/L) while Sri Lankan national guideline identified 15 distinctive GDM cases at a lower cut-off for 2-h glucose (from 7.8 to 8.4 mmol/L). After adjusting for age, GDM diagnosed by IADPSG criteria was associated with higher birthweight [90.8 g, 95% CI: 10.8, 170.9], while the associations for GDM diagnosed either by Sri Lankan national or WHO 1999 guidelines were not significant.Conclusion: Adopting the IADPSG criteria for diagnosing GDM may be important in Sri Lankan pregnant population.https://www.frontiersin.org/article/10.3389/fendo.2018.00682/fullgestational diabetes mellitusscreeningpregnancyIADSPGWHO 1999 |
| spellingShingle | Thiran Dias Shahul Hameed Mohamed Siraj Izzuddin Mohamed Aris Ling-Jun Li Ling-Jun Li Ling-Jun Li Kok Hian Tan Kok Hian Tan Comparing Different Diagnostic Guidelines for Gestational Diabetes Mellitus in Relation to Birthweight in Sri Lankan Women Frontiers in Endocrinology gestational diabetes mellitus screening pregnancy IADSPG WHO 1999 |
| title | Comparing Different Diagnostic Guidelines for Gestational Diabetes Mellitus in Relation to Birthweight in Sri Lankan Women |
| title_full | Comparing Different Diagnostic Guidelines for Gestational Diabetes Mellitus in Relation to Birthweight in Sri Lankan Women |
| title_fullStr | Comparing Different Diagnostic Guidelines for Gestational Diabetes Mellitus in Relation to Birthweight in Sri Lankan Women |
| title_full_unstemmed | Comparing Different Diagnostic Guidelines for Gestational Diabetes Mellitus in Relation to Birthweight in Sri Lankan Women |
| title_short | Comparing Different Diagnostic Guidelines for Gestational Diabetes Mellitus in Relation to Birthweight in Sri Lankan Women |
| title_sort | comparing different diagnostic guidelines for gestational diabetes mellitus in relation to birthweight in sri lankan women |
| topic | gestational diabetes mellitus screening pregnancy IADSPG WHO 1999 |
| url | https://www.frontiersin.org/article/10.3389/fendo.2018.00682/full |
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