A controlled, double blind, study of adding Nalbuphine to Propofol for laryngeal mask insertion conditions and hemodynamics in adults
Purpose: The purpose of this study was to evaluate laryngeal mask airway placement conditions achieved with Nalbuphine/Propofol combination when given intravenously as well as hemodynamic changes if any. Methods: 60 ASA grade 1 and 11 patients of age group 20–60 years, scheduled for general anesthes...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2015-10-01
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| Series: | Egyptian Journal of Anaesthesia |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110184915000549 |
| _version_ | 1818446703773089792 |
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| author | Ossama Hamdy Salman |
| author_facet | Ossama Hamdy Salman |
| author_sort | Ossama Hamdy Salman |
| collection | DOAJ |
| description | Purpose: The purpose of this study was to evaluate laryngeal mask airway placement conditions achieved with Nalbuphine/Propofol combination when given intravenously as well as hemodynamic changes if any.
Methods: 60 ASA grade 1 and 11 patients of age group 20–60 years, scheduled for general anesthesia with spontaneous breathing were randomly allocated to receive intravenously either Fentanyl 2 μg/kg, controlled group (Group F, n = 30) or Nalbuphine 0.2 mg/kg (Group N, n = 30), before induction of anesthesia with Propofol 2–2.5 mg/kg. Heart rate and arterial blood pressure were measured before induction of anesthesia and at 1, 3, and 5 min after LMA insertion. Assessment of LMA insertion was done using 6 variables: mouth opening, gagging, swallowing, head and limb movements, laryngospasm and resistance to insertion. Incidence and duration of apnea were recorded.
Results: The incidence of coughing/gagging was higher in the F group (50%) compared to the N group (30%), (P = 0.019). Swallowing was also statistically significant (P = 0.017), being higher in F group (50%), compared to N group (16.6%). Limb moving followed the same pattern being higher in the F group (40%) compared to (13.3%) in the N group, (P = 0.008). Laryngospasm was seen in neither group. There was also statistically significant difference (P = 0.007) in the incidence of apnea between the control group (F) 86.6% and (N) group. Heart rate variation and MAP changes were not statistically significant in either F or N groups.
Conclusion: The addition of Nalbuphine to Propofol for LMA insertion provides excellent insertion conditions with stable hemodynamics in adults. |
| first_indexed | 2024-12-14T19:51:57Z |
| format | Article |
| id | doaj.art-62b127f22913403d9a6771cf5ceaa996 |
| institution | Directory Open Access Journal |
| issn | 1110-1849 |
| language | English |
| last_indexed | 2024-12-14T19:51:57Z |
| publishDate | 2015-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Egyptian Journal of Anaesthesia |
| spelling | doaj.art-62b127f22913403d9a6771cf5ceaa9962022-12-21T22:49:24ZengTaylor & Francis GroupEgyptian Journal of Anaesthesia1110-18492015-10-0131427728110.1016/j.egja.2015.03.009A controlled, double blind, study of adding Nalbuphine to Propofol for laryngeal mask insertion conditions and hemodynamics in adultsOssama Hamdy SalmanPurpose: The purpose of this study was to evaluate laryngeal mask airway placement conditions achieved with Nalbuphine/Propofol combination when given intravenously as well as hemodynamic changes if any. Methods: 60 ASA grade 1 and 11 patients of age group 20–60 years, scheduled for general anesthesia with spontaneous breathing were randomly allocated to receive intravenously either Fentanyl 2 μg/kg, controlled group (Group F, n = 30) or Nalbuphine 0.2 mg/kg (Group N, n = 30), before induction of anesthesia with Propofol 2–2.5 mg/kg. Heart rate and arterial blood pressure were measured before induction of anesthesia and at 1, 3, and 5 min after LMA insertion. Assessment of LMA insertion was done using 6 variables: mouth opening, gagging, swallowing, head and limb movements, laryngospasm and resistance to insertion. Incidence and duration of apnea were recorded. Results: The incidence of coughing/gagging was higher in the F group (50%) compared to the N group (30%), (P = 0.019). Swallowing was also statistically significant (P = 0.017), being higher in F group (50%), compared to N group (16.6%). Limb moving followed the same pattern being higher in the F group (40%) compared to (13.3%) in the N group, (P = 0.008). Laryngospasm was seen in neither group. There was also statistically significant difference (P = 0.007) in the incidence of apnea between the control group (F) 86.6% and (N) group. Heart rate variation and MAP changes were not statistically significant in either F or N groups. Conclusion: The addition of Nalbuphine to Propofol for LMA insertion provides excellent insertion conditions with stable hemodynamics in adults.http://www.sciencedirect.com/science/article/pii/S1110184915000549Laryngeal mask airway (LMA)American Society of Anesthetists (ASA)Mean arterial pressure (MAP) |
| spellingShingle | Ossama Hamdy Salman A controlled, double blind, study of adding Nalbuphine to Propofol for laryngeal mask insertion conditions and hemodynamics in adults Egyptian Journal of Anaesthesia Laryngeal mask airway (LMA) American Society of Anesthetists (ASA) Mean arterial pressure (MAP) |
| title | A controlled, double blind, study of adding Nalbuphine to Propofol for laryngeal mask insertion conditions and hemodynamics in adults |
| title_full | A controlled, double blind, study of adding Nalbuphine to Propofol for laryngeal mask insertion conditions and hemodynamics in adults |
| title_fullStr | A controlled, double blind, study of adding Nalbuphine to Propofol for laryngeal mask insertion conditions and hemodynamics in adults |
| title_full_unstemmed | A controlled, double blind, study of adding Nalbuphine to Propofol for laryngeal mask insertion conditions and hemodynamics in adults |
| title_short | A controlled, double blind, study of adding Nalbuphine to Propofol for laryngeal mask insertion conditions and hemodynamics in adults |
| title_sort | controlled double blind study of adding nalbuphine to propofol for laryngeal mask insertion conditions and hemodynamics in adults |
| topic | Laryngeal mask airway (LMA) American Society of Anesthetists (ASA) Mean arterial pressure (MAP) |
| url | http://www.sciencedirect.com/science/article/pii/S1110184915000549 |
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