Alpha-synuclein/synapsin III pathological interplay boosts the motor response to methylphenidate

Alpha-synuclein/synapsin III pathological interplay boosts the motor response to methylphenidate

Loss of dopaminergic nigrostriatal neurons and fibrillary α-synuclein (α-syn) aggregation in Lewy bodies (LB) characterize Parkinson's disease (PD). We recently found that Synapsin III (Syn III), a phosphoprotein regulating dopamine (DA) release with α-syn, is another key component of LB fibril...

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Main Authors: Gaia Faustini, Francesca Longhena, Agostino Bruno, Federica Bono, Jessica Grigoletto, Luca La Via, Alessandro Barbon, Andrea Casiraghi, Valentina Straniero, Ermanno Valoti, Gabriele Costantino, Fabio Benfenati, Cristina Missale, Marina Pizzi, Maria Grazia Spillantini, Arianna Bellucci
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
α-Synuclein
Synapsin III
Methylphenidate
Cocaine
Motor behaviour
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120300644

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