Treatment of Chronic Kidney Diseases with Histone Deacetylase Inhibitors
Histone deacetylases (HDACs) induce deacetylation of both histone and non-histone proteins and play a critical role in the modulation of physiological and pathological gene expression. Pharmacological inhibition of HDAC has been reported to attenuate progression of renal fibrogenesis in obstructed k...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-04-01
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| Series: | Frontiers in Physiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00121/full |
| _version_ | 1818930043270725632 |
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| author | Shougang eZhuang Na eLiu |
| author_facet | Shougang eZhuang Na eLiu |
| author_sort | Shougang eZhuang |
| collection | DOAJ |
| description | Histone deacetylases (HDACs) induce deacetylation of both histone and non-histone proteins and play a critical role in the modulation of physiological and pathological gene expression. Pharmacological inhibition of HDAC has been reported to attenuate progression of renal fibrogenesis in obstructed kidney and reduce cyst formation in polycystic kidney disease. HDAC inhibitors (HDACis) are also able to ameliorate renal lesions in diabetes nephropathy, lupus nephritis, aristolochic acid nephropathy and transplant nephropathy. The beneficial effects of HDACis are associated with their anti-fibrosis, anti-inflammation, and immmunosuppressant effects. In this review, we summarize recent advances on the treatment of various chronic kidney diseases with HDACis in preclinical models. |
| first_indexed | 2024-12-20T03:54:25Z |
| format | Article |
| id | doaj.art-62b6407ad69841c1aabf68422f5a28ab |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-20T03:54:25Z |
| publishDate | 2015-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-62b6407ad69841c1aabf68422f5a28ab2022-12-21T19:54:22ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2015-04-01610.3389/fphys.2015.00121131997Treatment of Chronic Kidney Diseases with Histone Deacetylase InhibitorsShougang eZhuang0Na eLiu1Rhode Island Hospital and Aplert Medical School, Brown UniversityShanghai East Hospital, Tongji University School of MedicineHistone deacetylases (HDACs) induce deacetylation of both histone and non-histone proteins and play a critical role in the modulation of physiological and pathological gene expression. Pharmacological inhibition of HDAC has been reported to attenuate progression of renal fibrogenesis in obstructed kidney and reduce cyst formation in polycystic kidney disease. HDAC inhibitors (HDACis) are also able to ameliorate renal lesions in diabetes nephropathy, lupus nephritis, aristolochic acid nephropathy and transplant nephropathy. The beneficial effects of HDACis are associated with their anti-fibrosis, anti-inflammation, and immmunosuppressant effects. In this review, we summarize recent advances on the treatment of various chronic kidney diseases with HDACis in preclinical models.http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00121/fullHistone DeacetylasesLupus Nephritischronic kidney diseasesrenal fibrosisDiabetes nephropathyrenal fibroblasts |
| spellingShingle | Shougang eZhuang Na eLiu Treatment of Chronic Kidney Diseases with Histone Deacetylase Inhibitors Frontiers in Physiology Histone Deacetylases Lupus Nephritis chronic kidney diseases renal fibrosis Diabetes nephropathy renal fibroblasts |
| title | Treatment of Chronic Kidney Diseases with Histone Deacetylase Inhibitors |
| title_full | Treatment of Chronic Kidney Diseases with Histone Deacetylase Inhibitors |
| title_fullStr | Treatment of Chronic Kidney Diseases with Histone Deacetylase Inhibitors |
| title_full_unstemmed | Treatment of Chronic Kidney Diseases with Histone Deacetylase Inhibitors |
| title_short | Treatment of Chronic Kidney Diseases with Histone Deacetylase Inhibitors |
| title_sort | treatment of chronic kidney diseases with histone deacetylase inhibitors |
| topic | Histone Deacetylases Lupus Nephritis chronic kidney diseases renal fibrosis Diabetes nephropathy renal fibroblasts |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00121/full |
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