From Research to Diagnostic Application of Raman Spectroscopy in Neurosciences: Past and Perspectives
In recent years, Raman spectroscopy has been more and more frequently applied to address research questions in neuroscience. As a non-destructive technique based on inelastic scattering of photons, it can be used for a wide spectrum of applications including neurooncological tumor diagnostics or an...
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| Format: | Article |
| Language: | English |
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University of Münster / Open Journals System
2022-08-01
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| Series: | Free Neuropathology |
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| Online Access: | https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/4210 |
| _version_ | 1828379625795878912 |
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| author | Gilbert Georg Klamminger Katrin Frauenknecht Michel Mittelbronn Felix Bruno Kleine Borgmann |
| author_facet | Gilbert Georg Klamminger Katrin Frauenknecht Michel Mittelbronn Felix Bruno Kleine Borgmann |
| author_sort | Gilbert Georg Klamminger |
| collection | DOAJ |
| description |
In recent years, Raman spectroscopy has been more and more frequently applied to address research questions in neuroscience. As a non-destructive technique based on inelastic scattering of photons, it can be used for a wide spectrum of applications including neurooncological tumor diagnostics or analysis of misfolded protein aggregates involved in neurodegenerative diseases. Progress in the technical development of this method allows for an increasingly detailed analysis of biological samples and may therefore open new fields of applications. The goal of our review is to provide an introduction into Raman scattering, its practical usage and also commonly associated pitfalls. Furthermore, intraoperative assessment of tumor recurrence using Raman based histology images as well as the search for non-invasive ways of diagnosis in neurodegenerative diseases are discussed. Some of the applications mentioned here may serve as a basis and possibly set the course for a future use of the technique in clinical practice. Covering a broad range of content, this overview can serve not only as a quick and accessible reference tool but also provide more in-depth information on a specific subtopic of interest.
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| first_indexed | 2024-12-10T03:43:05Z |
| format | Article |
| id | doaj.art-62ba21e5e111420ca10c2fe0643e49d1 |
| institution | Directory Open Access Journal |
| issn | 2699-4445 |
| language | English |
| last_indexed | 2024-12-10T03:43:05Z |
| publishDate | 2022-08-01 |
| publisher | University of Münster / Open Journals System |
| record_format | Article |
| series | Free Neuropathology |
| spelling | doaj.art-62ba21e5e111420ca10c2fe0643e49d12022-12-22T02:03:30ZengUniversity of Münster / Open Journals SystemFree Neuropathology2699-44452022-08-013From Research to Diagnostic Application of Raman Spectroscopy in Neurosciences: Past and PerspectivesGilbert Georg Klamminger0Katrin Frauenknecht1Michel Mittelbronn2Felix Bruno Kleine Borgmann3Saarland University Medical Center and Faculty of Medicine, Homburg, Germany; National Center of Pathology (NCP), Laboratoire national de santé (LNS), Dudelange, Luxembourg, Luxembourg Center of Neuropathology (LCNP), Dudelange, LuxembourgNational Center of Pathology (NCP), Laboratoire national de santé (LNS), Dudelange, Luxembourg; Luxembourg Center of Neuropathology (LCNP), Dudelange, LuxembourgNational Center of Pathology (NCP), Laboratoire national de santé (LNS), Dudelange, Luxembourg; Luxembourg Center of Neuropathology (LCNP), Dudelange, Luxembourg; Luxembourg Centre of Systems Biomedicine (LCSB), University of Luxembourg (UL), Esch-sur-Alzette, Luxembourg; Department of Cancer Research (DoCR), Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg; Department of Life Sciences and Medicine (DLSM); University of Luxembourg; Esch-sur-Alzette, Luxembourg; Faculty of Science, Technology and Medicine (FSTM), University of Luxembourg, Esch-sur-Alzette, LuxembourgNational Center of Pathology (NCP), Laboratoire national de santé (LNS), Dudelange, Luxembourg; Luxembourg Center of Neuropathology (LCNP), Dudelange, Luxembourg; Saarland University Medical Center and Faculty of Medicine, Homburg, Germany ; Department of Cancer Research (DoCR), Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg In recent years, Raman spectroscopy has been more and more frequently applied to address research questions in neuroscience. As a non-destructive technique based on inelastic scattering of photons, it can be used for a wide spectrum of applications including neurooncological tumor diagnostics or analysis of misfolded protein aggregates involved in neurodegenerative diseases. Progress in the technical development of this method allows for an increasingly detailed analysis of biological samples and may therefore open new fields of applications. The goal of our review is to provide an introduction into Raman scattering, its practical usage and also commonly associated pitfalls. Furthermore, intraoperative assessment of tumor recurrence using Raman based histology images as well as the search for non-invasive ways of diagnosis in neurodegenerative diseases are discussed. Some of the applications mentioned here may serve as a basis and possibly set the course for a future use of the technique in clinical practice. Covering a broad range of content, this overview can serve not only as a quick and accessible reference tool but also provide more in-depth information on a specific subtopic of interest. https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/4210Raman spectroscopyNeurooncologyNeurodegenerationNeurosurgeryNeuropathologyMachine learning |
| spellingShingle | Gilbert Georg Klamminger Katrin Frauenknecht Michel Mittelbronn Felix Bruno Kleine Borgmann From Research to Diagnostic Application of Raman Spectroscopy in Neurosciences: Past and Perspectives Free Neuropathology Raman spectroscopy Neurooncology Neurodegeneration Neurosurgery Neuropathology Machine learning |
| title | From Research to Diagnostic Application of Raman Spectroscopy in Neurosciences: Past and Perspectives |
| title_full | From Research to Diagnostic Application of Raman Spectroscopy in Neurosciences: Past and Perspectives |
| title_fullStr | From Research to Diagnostic Application of Raman Spectroscopy in Neurosciences: Past and Perspectives |
| title_full_unstemmed | From Research to Diagnostic Application of Raman Spectroscopy in Neurosciences: Past and Perspectives |
| title_short | From Research to Diagnostic Application of Raman Spectroscopy in Neurosciences: Past and Perspectives |
| title_sort | from research to diagnostic application of raman spectroscopy in neurosciences past and perspectives |
| topic | Raman spectroscopy Neurooncology Neurodegeneration Neurosurgery Neuropathology Machine learning |
| url | https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/4210 |
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