Hyaluronic Acid in Rheumatology
Hyaluronic acid (HA), also known as hyaluronan, is an anionic glycosaminoglycan widely distributed throughout various tissues of the human body. It stands out from other glycosaminoglycans as it lacks sulfation and can attain considerable size: the average human synovial HA molecule weighs about 7 m...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-08-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/9/2247 |
| _version_ | 1797577951443681280 |
|---|---|
| author | Haiko Sprott Christian Fleck |
| author_facet | Haiko Sprott Christian Fleck |
| author_sort | Haiko Sprott |
| collection | DOAJ |
| description | Hyaluronic acid (HA), also known as hyaluronan, is an anionic glycosaminoglycan widely distributed throughout various tissues of the human body. It stands out from other glycosaminoglycans as it lacks sulfation and can attain considerable size: the average human synovial HA molecule weighs about 7 million Dalton (Da), equivalent to roughly 20,000 disaccharide monomers; although some sources report a lower range of 3–4 million Da. In recent years, HA has garnered significant attention in the field of rheumatology due to its involvement in joint lubrication, cartilage maintenance, and modulation of inflammatory and/or immune responses. This review aims to provide a comprehensive overview of HA’s involvement in rheumatology, covering its physiology, pharmacology, therapeutic applications, and potential future directions for enhancing patient outcomes. Nevertheless, the use of HA therapy in rheumatology remains controversial with conflicting evidence regarding its efficacy and safety. In conclusion, HA represents a promising therapeutic option to improve joint function and alleviate inflammation and pain. |
| first_indexed | 2024-03-10T22:15:21Z |
| format | Article |
| id | doaj.art-62bada2337ae4a2f82c3a909ad82e626 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T22:15:21Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-62bada2337ae4a2f82c3a909ad82e6262023-11-19T12:27:03ZengMDPI AGPharmaceutics1999-49232023-08-01159224710.3390/pharmaceutics15092247Hyaluronic Acid in RheumatologyHaiko Sprott0Christian Fleck1Medical Faculty, University of Zurich (UZH), CH-8006 Zurich, SwitzerlandMedical Faculty, University of Jena, D-07743 Jena, GermanyHyaluronic acid (HA), also known as hyaluronan, is an anionic glycosaminoglycan widely distributed throughout various tissues of the human body. It stands out from other glycosaminoglycans as it lacks sulfation and can attain considerable size: the average human synovial HA molecule weighs about 7 million Dalton (Da), equivalent to roughly 20,000 disaccharide monomers; although some sources report a lower range of 3–4 million Da. In recent years, HA has garnered significant attention in the field of rheumatology due to its involvement in joint lubrication, cartilage maintenance, and modulation of inflammatory and/or immune responses. This review aims to provide a comprehensive overview of HA’s involvement in rheumatology, covering its physiology, pharmacology, therapeutic applications, and potential future directions for enhancing patient outcomes. Nevertheless, the use of HA therapy in rheumatology remains controversial with conflicting evidence regarding its efficacy and safety. In conclusion, HA represents a promising therapeutic option to improve joint function and alleviate inflammation and pain.https://www.mdpi.com/1999-4923/15/9/2247hyaluronic acidrheumatologyosteoarthritisrheumatoid arthritisjoint lubricationcartilage |
| spellingShingle | Haiko Sprott Christian Fleck Hyaluronic Acid in Rheumatology Pharmaceutics hyaluronic acid rheumatology osteoarthritis rheumatoid arthritis joint lubrication cartilage |
| title | Hyaluronic Acid in Rheumatology |
| title_full | Hyaluronic Acid in Rheumatology |
| title_fullStr | Hyaluronic Acid in Rheumatology |
| title_full_unstemmed | Hyaluronic Acid in Rheumatology |
| title_short | Hyaluronic Acid in Rheumatology |
| title_sort | hyaluronic acid in rheumatology |
| topic | hyaluronic acid rheumatology osteoarthritis rheumatoid arthritis joint lubrication cartilage |
| url | https://www.mdpi.com/1999-4923/15/9/2247 |
| work_keys_str_mv | AT haikosprott hyaluronicacidinrheumatology AT christianfleck hyaluronicacidinrheumatology |