A case of pulmonary tumor thrombotic microangiopathy following lymphedema on the lower extremities
Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare manifestation of malignancy. The antemortem diagnosis is difficult, since patients present with rapidly progressive symptoms. We recently observed a case of PTTM following lymphedema of the lower extremities. We did not reach a diagnosis, e...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Respiratory Medicine Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007122000533 |
| _version_ | 1818207939577511936 |
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| author | Yuri Shiraiwa Yuri Taniguchi Mari Hyoudou Aya Shiba Masaharu Aga Kazuhito Miyazaki Yusuke Hamakawa Yuki Misumi Yoko Agemi Tsuneo Shimokawa Chie Hasegawa Hiroyuki Hayashi Hiroaki Okamoto |
| author_facet | Yuri Shiraiwa Yuri Taniguchi Mari Hyoudou Aya Shiba Masaharu Aga Kazuhito Miyazaki Yusuke Hamakawa Yuki Misumi Yoko Agemi Tsuneo Shimokawa Chie Hasegawa Hiroyuki Hayashi Hiroaki Okamoto |
| author_sort | Yuri Shiraiwa |
| collection | DOAJ |
| description | Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare manifestation of malignancy. The antemortem diagnosis is difficult, since patients present with rapidly progressive symptoms. We recently observed a case of PTTM following lymphedema of the lower extremities. We did not reach a diagnosis, even after performing BAL and TBLB. The patient manifested pulmonary hypertension and died on the 9th day of admission. Autopsy revealed a tumor embolism in the pulmonary arterioles accompanied by fibrocellular epithelial cell proliferation, but the primary organ was not identified. To our knowledge, this is the first reported case of PTTM with lymphedema. |
| first_indexed | 2024-12-12T04:36:53Z |
| format | Article |
| id | doaj.art-62baeba8325d4f8e8384462320fb3543 |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-12-12T04:36:53Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-62baeba8325d4f8e8384462320fb35432022-12-22T00:37:55ZengElsevierRespiratory Medicine Case Reports2213-00712022-01-0137101631A case of pulmonary tumor thrombotic microangiopathy following lymphedema on the lower extremitiesYuri Shiraiwa0Yuri Taniguchi1Mari Hyoudou2Aya Shiba3Masaharu Aga4Kazuhito Miyazaki5Yusuke Hamakawa6Yuki Misumi7Yoko Agemi8Tsuneo Shimokawa9Chie Hasegawa10Hiroyuki Hayashi11Hiroaki Okamoto12Department of Respiratory Medicine, Yokohama Municipal Citizen's Hospital, 1-1 Mitsuzawa-nishimachi, Kanagawa-ku, Yokohama, Kanagawa, 221-0855, Japan; Corresponding author.Department of Respiratory Medicine, Yokohama Municipal Citizen's Hospital, 1-1 Mitsuzawa-nishimachi, Kanagawa-ku, Yokohama, Kanagawa, 221-0855, JapanDepartment of Respiratory Medicine, Yokohama Municipal Citizen's Hospital, 1-1 Mitsuzawa-nishimachi, Kanagawa-ku, Yokohama, Kanagawa, 221-0855, JapanDepartment of Respiratory Medicine, Yokohama Municipal Citizen's Hospital, 1-1 Mitsuzawa-nishimachi, Kanagawa-ku, Yokohama, Kanagawa, 221-0855, JapanDepartment of Respiratory Medicine, Yokohama Municipal Citizen's Hospital, 1-1 Mitsuzawa-nishimachi, Kanagawa-ku, Yokohama, Kanagawa, 221-0855, JapanDepartment of Respiratory Medicine, Yokohama Municipal Citizen's Hospital, 1-1 Mitsuzawa-nishimachi, Kanagawa-ku, Yokohama, Kanagawa, 221-0855, JapanDepartment of Respiratory Medicine, Yokohama Municipal Citizen's Hospital, 1-1 Mitsuzawa-nishimachi, Kanagawa-ku, Yokohama, Kanagawa, 221-0855, JapanDepartment of Respiratory Medicine, Yokohama Municipal Citizen's Hospital, 1-1 Mitsuzawa-nishimachi, Kanagawa-ku, Yokohama, Kanagawa, 221-0855, JapanDepartment of Respiratory Medicine, Yokohama Municipal Citizen's Hospital, 1-1 Mitsuzawa-nishimachi, Kanagawa-ku, Yokohama, Kanagawa, 221-0855, JapanDepartment of Respiratory Medicine, Yokohama Municipal Citizen's Hospital, 1-1 Mitsuzawa-nishimachi, Kanagawa-ku, Yokohama, Kanagawa, 221-0855, JapanDepartment of Pathology, Yokohama Municipal Citizen's Hospital, JapanDepartment of Pathology, Yokohama Municipal Citizen's Hospital, JapanDepartment of Respiratory Medicine, Yokohama Municipal Citizen's Hospital, 1-1 Mitsuzawa-nishimachi, Kanagawa-ku, Yokohama, Kanagawa, 221-0855, JapanPulmonary tumor thrombotic microangiopathy (PTTM) is a rare manifestation of malignancy. The antemortem diagnosis is difficult, since patients present with rapidly progressive symptoms. We recently observed a case of PTTM following lymphedema of the lower extremities. We did not reach a diagnosis, even after performing BAL and TBLB. The patient manifested pulmonary hypertension and died on the 9th day of admission. Autopsy revealed a tumor embolism in the pulmonary arterioles accompanied by fibrocellular epithelial cell proliferation, but the primary organ was not identified. To our knowledge, this is the first reported case of PTTM with lymphedema.http://www.sciencedirect.com/science/article/pii/S2213007122000533Pulmonary tumor thrombus microangiopathyPTTMLymphedemaAdenocarcinomaUnknown origin |
| spellingShingle | Yuri Shiraiwa Yuri Taniguchi Mari Hyoudou Aya Shiba Masaharu Aga Kazuhito Miyazaki Yusuke Hamakawa Yuki Misumi Yoko Agemi Tsuneo Shimokawa Chie Hasegawa Hiroyuki Hayashi Hiroaki Okamoto A case of pulmonary tumor thrombotic microangiopathy following lymphedema on the lower extremities Respiratory Medicine Case Reports Pulmonary tumor thrombus microangiopathy PTTM Lymphedema Adenocarcinoma Unknown origin |
| title | A case of pulmonary tumor thrombotic microangiopathy following lymphedema on the lower extremities |
| title_full | A case of pulmonary tumor thrombotic microangiopathy following lymphedema on the lower extremities |
| title_fullStr | A case of pulmonary tumor thrombotic microangiopathy following lymphedema on the lower extremities |
| title_full_unstemmed | A case of pulmonary tumor thrombotic microangiopathy following lymphedema on the lower extremities |
| title_short | A case of pulmonary tumor thrombotic microangiopathy following lymphedema on the lower extremities |
| title_sort | case of pulmonary tumor thrombotic microangiopathy following lymphedema on the lower extremities |
| topic | Pulmonary tumor thrombus microangiopathy PTTM Lymphedema Adenocarcinoma Unknown origin |
| url | http://www.sciencedirect.com/science/article/pii/S2213007122000533 |
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