Molecular Mechanism of Food-Derived Polyphenols on PD-L1 Dimerization: A Molecular Dynamics Simulation Study

Molecular Mechanism of Food-Derived Polyphenols on PD-L1 Dimerization: A Molecular Dynamics Simulation Study

In cancer immunotherapy, an emerging approach is to block the interactions of programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) using small-molecule inhibitors. The food-derived polyphenols curcumin (CC), resveratrol (RSV) and epigallocatechin gallate (EGCG) have anticancer i...

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Bibliographic Details
Main Authors: Yan Guo, Jianhuai Liang, Boping Liu, Yulong Jin
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
PD-1/PD-L1 pathway
food-derived polyphenols
small-molecule inhibitors
molecular docking
molecular dynamics simulation
Online Access:https://www.mdpi.com/1422-0067/22/20/10924

Internet

https://www.mdpi.com/1422-0067/22/20/10924

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