Single therapeutic dose of an antiviral UL29 siRNA swarm diminishes symptoms and viral load of mice infected intranasally with HSV‐1

Single therapeutic dose of an antiviral UL29 siRNA swarm diminishes symptoms and viral load of mice infected intranasally with HSV‐1

Abstract Herpes simplex virus type 1 (HSV‐1) is a human pathogen that causes recurrent infections. Acyclovir‐resistant strains exist and can cause severe complications, which are potentially untreatable with current therapies. We have developed siRNA swarms that target a 653 base pair long region of...

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Bibliographic Details
Main Authors: Tuomas Lasanen, Fanny Frejborg, Liisa M. Lund, Marie C. Nyman, Julius Orpana, Huda Habib, Salla Alaollitervo, Alesia A. Levanova, Minna M. Poranen, Veijo Hukkanen, Kiira Kalke
Format: Article
Language:English
Published: Wiley-VCH 2023-05-01
Series:Smart Medicine
Subjects:
antiviral
herpes simplex virus
infection models
intranasal
RNA interference
siRNA swarms
Online Access:https://doi.org/10.1002/SMMD.20230009

Internet

https://doi.org/10.1002/SMMD.20230009

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