Caspofungin Cerebral Penetration and Therapeutic Efficacy in Experimental Cerebral Aspergillosis

Caspofungin Cerebral Penetration and Therapeutic Efficacy in Experimental Cerebral Aspergillosis

ABSTRACT Despite best available therapy, cerebral aspergillosis is an often-lethal complication of disseminated aspergillosis. There is an urgent need to expand the currently limited therapeutic options. In this study, we assessed cerebral drug exposure and efficacy of caspofungin (CAS) using a leth...

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Bibliographic Details
Main Authors: Irina Ullmann, Andrea Aregger, Stephen L. Leib, Stefan Zimmerli
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:Microbiology Spectrum
Subjects:
cerebral aspergillosis
antifungal therapy
caspofungin
CNS drug penetration
animal model
rat
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02753-21

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