The Role of EMT-Related lncRNAs in Ovarian Cancer
Ovarian cancer (OC) is one of the deadliest cancers worldwide; late diagnosis and drug resistance are two major factors often responsible for high morbidity and treatment failure. Epithelial-to-mesenchymal transition (EMT) is a dynamic process that has been closely linked with cancer. Long non-codin...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-06-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/12/10079 |
| _version_ | 1797594353867161600 |
|---|---|
| author | Dimitra Ioanna Lampropoulou Marios Papadimitriou Christos Papadimitriou Dimitrios Filippou Georgia Kourlaba Gerasimos Aravantinos Maria Gazouli |
| author_facet | Dimitra Ioanna Lampropoulou Marios Papadimitriou Christos Papadimitriou Dimitrios Filippou Georgia Kourlaba Gerasimos Aravantinos Maria Gazouli |
| author_sort | Dimitra Ioanna Lampropoulou |
| collection | DOAJ |
| description | Ovarian cancer (OC) is one of the deadliest cancers worldwide; late diagnosis and drug resistance are two major factors often responsible for high morbidity and treatment failure. Epithelial-to-mesenchymal transition (EMT) is a dynamic process that has been closely linked with cancer. Long non-coding RNAs (lncRNAs) have been also associated with several cancer-related mechanisms, including EMT. We conducted a literature search in the PubMed database in order to sum up and discuss the role of lncRNAs in regulating OC-related EMT and their underlying mechanisms. Seventy (70) original research articles were identified, as of 23 April 2023. Our review concluded that the dysregulation of lncRNAs is highly associated with EMT-mediated OC progression. A comprehensive understanding of lncRNAs’ mechanisms in OC will help in identifying novel and sensitive biomarkers and therapeutic targets for this malignancy. |
| first_indexed | 2024-03-11T02:21:21Z |
| format | Article |
| id | doaj.art-62c09a18d9f2422090b2deb749d5d438 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T02:21:21Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-62c09a18d9f2422090b2deb749d5d4382023-11-18T10:48:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124121007910.3390/ijms241210079The Role of EMT-Related lncRNAs in Ovarian CancerDimitra Ioanna Lampropoulou0Marios Papadimitriou1Christos Papadimitriou2Dimitrios Filippou3Georgia Kourlaba4Gerasimos Aravantinos5Maria Gazouli6ECONCARE LP, Health Research & Consulting, 11528 Athens, GreeceMyeloma Division, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USASecond Department of Surgery, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceDepartment of Anatomy and Surgical Anatomy, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceDepartment of Nursing, University of Peloponnese, 22100 Tripoli, GreeceEuroclinic, Athanasiadou 7-9, 11521 Athens, GreeceDepartment of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceOvarian cancer (OC) is one of the deadliest cancers worldwide; late diagnosis and drug resistance are two major factors often responsible for high morbidity and treatment failure. Epithelial-to-mesenchymal transition (EMT) is a dynamic process that has been closely linked with cancer. Long non-coding RNAs (lncRNAs) have been also associated with several cancer-related mechanisms, including EMT. We conducted a literature search in the PubMed database in order to sum up and discuss the role of lncRNAs in regulating OC-related EMT and their underlying mechanisms. Seventy (70) original research articles were identified, as of 23 April 2023. Our review concluded that the dysregulation of lncRNAs is highly associated with EMT-mediated OC progression. A comprehensive understanding of lncRNAs’ mechanisms in OC will help in identifying novel and sensitive biomarkers and therapeutic targets for this malignancy.https://www.mdpi.com/1422-0067/24/12/10079lncRNAsovarian cancerEMTbiomarkers |
| spellingShingle | Dimitra Ioanna Lampropoulou Marios Papadimitriou Christos Papadimitriou Dimitrios Filippou Georgia Kourlaba Gerasimos Aravantinos Maria Gazouli The Role of EMT-Related lncRNAs in Ovarian Cancer International Journal of Molecular Sciences lncRNAs ovarian cancer EMT biomarkers |
| title | The Role of EMT-Related lncRNAs in Ovarian Cancer |
| title_full | The Role of EMT-Related lncRNAs in Ovarian Cancer |
| title_fullStr | The Role of EMT-Related lncRNAs in Ovarian Cancer |
| title_full_unstemmed | The Role of EMT-Related lncRNAs in Ovarian Cancer |
| title_short | The Role of EMT-Related lncRNAs in Ovarian Cancer |
| title_sort | role of emt related lncrnas in ovarian cancer |
| topic | lncRNAs ovarian cancer EMT biomarkers |
| url | https://www.mdpi.com/1422-0067/24/12/10079 |
| work_keys_str_mv | AT dimitraioannalampropoulou theroleofemtrelatedlncrnasinovariancancer AT mariospapadimitriou theroleofemtrelatedlncrnasinovariancancer AT christospapadimitriou theroleofemtrelatedlncrnasinovariancancer AT dimitriosfilippou theroleofemtrelatedlncrnasinovariancancer AT georgiakourlaba theroleofemtrelatedlncrnasinovariancancer AT gerasimosaravantinos theroleofemtrelatedlncrnasinovariancancer AT mariagazouli theroleofemtrelatedlncrnasinovariancancer AT dimitraioannalampropoulou roleofemtrelatedlncrnasinovariancancer AT mariospapadimitriou roleofemtrelatedlncrnasinovariancancer AT christospapadimitriou roleofemtrelatedlncrnasinovariancancer AT dimitriosfilippou roleofemtrelatedlncrnasinovariancancer AT georgiakourlaba roleofemtrelatedlncrnasinovariancancer AT gerasimosaravantinos roleofemtrelatedlncrnasinovariancancer AT mariagazouli roleofemtrelatedlncrnasinovariancancer |