The Experimental overactive bladder modelling
An experimental study was conducted, which resulted in the development of a hyperactive urinary bladder model. Animals of the main group administered once daily for 14 days i.p. 0.3 ml of the hombiotensin, containing 0.45 mg of reserpine. This model development is confirmed by histological studies r...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Kazimierz Wielki University
2018-07-01
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| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/JEHS/article/view/25439 |
| _version_ | 1811301878443540480 |
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| author | O. I. Iatsyna R. S. Vastyanov I. M. Savytska S. V. Vernygorodskyi |
| author_facet | O. I. Iatsyna R. S. Vastyanov I. M. Savytska S. V. Vernygorodskyi |
| author_sort | O. I. Iatsyna |
| collection | DOAJ |
| description | An experimental study was conducted, which resulted in the development of a hyperactive urinary bladder model. Animals of the main group administered once daily for 14 days i.p. 0.3 ml of the hombiotensin, containing 0.45 mg of reserpine. This model development is confirmed by histological studies results. Morphological changes that arose in reproduction of the model of hyperactive bladder are determined by the following stages. Namely: compensatory hypertrophy of the wall with degenerative changes in smooth myocytes, disturbances of intercellular bonds due to the increase of immature collagen type 3 and type 4 in the early stages of observation (14 days), eventually leads to the depletion of adaptive capabilities with subsequent decompensation and sclerosis of the bladder wall at a late end of the experiment (28 days).
The obtained model meets the requirements for qualitative indicators in the study of morphological changes in hyperactive urinary bladder model and can be used as a basis in the preclinical stage of research. |
| first_indexed | 2024-04-13T07:16:43Z |
| format | Article |
| id | doaj.art-62c4227afcbf4d3d8a679a8432aa1a4d |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-04-13T07:16:43Z |
| publishDate | 2018-07-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-62c4227afcbf4d3d8a679a8432aa1a4d2022-12-22T02:56:43ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062018-07-0187The Experimental overactive bladder modellingO. I. Iatsyna0R. S. Vastyanov1I. M. Savytska2S. V. Vernygorodskyi3Odessa National Medical UniversityOdessa National Medical UniversityO.O. Shalimov national Institute of Surgery and TransplantologyМ.І. Pyrogov Vinnytsya National Medical UniversityAn experimental study was conducted, which resulted in the development of a hyperactive urinary bladder model. Animals of the main group administered once daily for 14 days i.p. 0.3 ml of the hombiotensin, containing 0.45 mg of reserpine. This model development is confirmed by histological studies results. Morphological changes that arose in reproduction of the model of hyperactive bladder are determined by the following stages. Namely: compensatory hypertrophy of the wall with degenerative changes in smooth myocytes, disturbances of intercellular bonds due to the increase of immature collagen type 3 and type 4 in the early stages of observation (14 days), eventually leads to the depletion of adaptive capabilities with subsequent decompensation and sclerosis of the bladder wall at a late end of the experiment (28 days). The obtained model meets the requirements for qualitative indicators in the study of morphological changes in hyperactive urinary bladder model and can be used as a basis in the preclinical stage of research.https://apcz.umk.pl/JEHS/article/view/25439hyperactive urinary bladderexperimental modelingratshombiotensindegenerationcollagen |
| spellingShingle | O. I. Iatsyna R. S. Vastyanov I. M. Savytska S. V. Vernygorodskyi The Experimental overactive bladder modelling Journal of Education, Health and Sport hyperactive urinary bladder experimental modeling rats hombiotensin degeneration collagen |
| title | The Experimental overactive bladder modelling |
| title_full | The Experimental overactive bladder modelling |
| title_fullStr | The Experimental overactive bladder modelling |
| title_full_unstemmed | The Experimental overactive bladder modelling |
| title_short | The Experimental overactive bladder modelling |
| title_sort | experimental overactive bladder modelling |
| topic | hyperactive urinary bladder experimental modeling rats hombiotensin degeneration collagen |
| url | https://apcz.umk.pl/JEHS/article/view/25439 |
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