Construction of Chi(Zn/BMP2)/HA composite coating on AZ31B magnesium alloy surface to improve the corrosion resistance and biocompatibility
As biodegradable orthopedic implant materials, magnesium alloys have been attracted enough attentions recently. However, too fast degradation in vivo, limited biocompatibilities, and insufficient antibacterial properties are three main challenges at present. In order to solve these problems, a multi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2021-08-01
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| Series: | Nanotechnology Reviews |
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| Online Access: | https://doi.org/10.1515/ntrev-2021-0063 |
| _version_ | 1818405323077058560 |
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| author | Zhang Qiuyang Zhang Li Yang Minhui Hong Qingxiang Yang Zhongmei Liu Sen Xiong Qingping Pan Changjiang |
| author_facet | Zhang Qiuyang Zhang Li Yang Minhui Hong Qingxiang Yang Zhongmei Liu Sen Xiong Qingping Pan Changjiang |
| author_sort | Zhang Qiuyang |
| collection | DOAJ |
| description | As biodegradable orthopedic implant materials, magnesium alloys have been attracted enough attentions recently. However, too fast degradation in vivo, limited biocompatibilities, and insufficient antibacterial properties are three main challenges at present. In order to solve these problems, a multifunctional composite coating of Chi(Zn/BMP2)/HA was constructed on AZ31B magnesium alloy surface, successively by the alkali heating treatment, self-assembly of 16-phosphonyl-hexadecanoic acid, in situ immobilization of Chi(Zn/BMP2) (chitosan, zinc ions, and bone morphogenetic protein 2), and the deposition of HA (hydroxyapatite). The results of ATR-FTIR (attenuated total reflection Fourier transform infrared spectrum) spectra and elemental compositions confirmed that 16-phosphonyl-hexadecanoic acid, Chi(Zn/BMP2), and HA were successfully immobilized on the surface. Compared with Mg, Mg-OH, Mg-16, and Mg-Chi(Zn/BMP2), Mg-Chi(Zn/BMP2)/HA with the concave–convex structure surface significantly enhanced the hydrophilicity and corrosion resistance. On the other hand, Mg-Chi(Zn/BMP2)/HA coating also showed excellent biocompatibilities, which not only significantly promoted the osteoblast adhesion and proliferation, but also upregulated ALP and OCN expression of osteoblasts. Furthermore, due to the synergistic antibacterial effect of zinc ions and chitosan, Mg-Chi(Zn/BMP2)/HA showed a good antibacterial property against Escherichia coli (E. coli). Therefore, it can be said that the method used in this work has a good application prospect in improving the corrosion resistance, biocompatibility of magnesium alloys, and inhibiting infections against E. coli. |
| first_indexed | 2024-12-14T08:54:13Z |
| format | Article |
| id | doaj.art-62c541c8ae2544739b2db5355a7b934e |
| institution | Directory Open Access Journal |
| issn | 2191-9097 |
| language | English |
| last_indexed | 2024-12-14T08:54:13Z |
| publishDate | 2021-08-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Nanotechnology Reviews |
| spelling | doaj.art-62c541c8ae2544739b2db5355a7b934e2022-12-21T23:08:58ZengDe GruyterNanotechnology Reviews2191-90972021-08-0110187088210.1515/ntrev-2021-0063Construction of Chi(Zn/BMP2)/HA composite coating on AZ31B magnesium alloy surface to improve the corrosion resistance and biocompatibilityZhang Qiuyang0Zhang Li1Yang Minhui2Hong Qingxiang3Yang Zhongmei4Liu Sen5Xiong Qingping6Pan Changjiang7Faculty of Mechanical and Material Engineering, Jiangsu Provincial Engineering Research Center for Biomedical Materials and Advanced Medical Devices, Huaiyin Institute of Technology, Huai’an 223003, ChinaThe Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an 223003, ChinaFaculty of Mechanical and Material Engineering, Jiangsu Provincial Engineering Research Center for Biomedical Materials and Advanced Medical Devices, Huaiyin Institute of Technology, Huai’an 223003, ChinaFaculty of Mechanical and Material Engineering, Jiangsu Provincial Engineering Research Center for Biomedical Materials and Advanced Medical Devices, Huaiyin Institute of Technology, Huai’an 223003, ChinaFaculty of Mechanical and Material Engineering, Jiangsu Provincial Engineering Research Center for Biomedical Materials and Advanced Medical Devices, Huaiyin Institute of Technology, Huai’an 223003, ChinaFaculty of Mechanical and Material Engineering, Jiangsu Provincial Engineering Research Center for Biomedical Materials and Advanced Medical Devices, Huaiyin Institute of Technology, Huai’an 223003, ChinaFaculty of Chemical Engineering, Huaiyin Institute of Technology, Huai’an 223003, ChinaFaculty of Mechanical and Material Engineering, Jiangsu Provincial Engineering Research Center for Biomedical Materials and Advanced Medical Devices, Huaiyin Institute of Technology, Huai’an 223003, ChinaAs biodegradable orthopedic implant materials, magnesium alloys have been attracted enough attentions recently. However, too fast degradation in vivo, limited biocompatibilities, and insufficient antibacterial properties are three main challenges at present. In order to solve these problems, a multifunctional composite coating of Chi(Zn/BMP2)/HA was constructed on AZ31B magnesium alloy surface, successively by the alkali heating treatment, self-assembly of 16-phosphonyl-hexadecanoic acid, in situ immobilization of Chi(Zn/BMP2) (chitosan, zinc ions, and bone morphogenetic protein 2), and the deposition of HA (hydroxyapatite). The results of ATR-FTIR (attenuated total reflection Fourier transform infrared spectrum) spectra and elemental compositions confirmed that 16-phosphonyl-hexadecanoic acid, Chi(Zn/BMP2), and HA were successfully immobilized on the surface. Compared with Mg, Mg-OH, Mg-16, and Mg-Chi(Zn/BMP2), Mg-Chi(Zn/BMP2)/HA with the concave–convex structure surface significantly enhanced the hydrophilicity and corrosion resistance. On the other hand, Mg-Chi(Zn/BMP2)/HA coating also showed excellent biocompatibilities, which not only significantly promoted the osteoblast adhesion and proliferation, but also upregulated ALP and OCN expression of osteoblasts. Furthermore, due to the synergistic antibacterial effect of zinc ions and chitosan, Mg-Chi(Zn/BMP2)/HA showed a good antibacterial property against Escherichia coli (E. coli). Therefore, it can be said that the method used in this work has a good application prospect in improving the corrosion resistance, biocompatibility of magnesium alloys, and inhibiting infections against E. coli.https://doi.org/10.1515/ntrev-2021-0063magnesium alloymultifunctional composite coatingscorrosion resistancebiocompatibilitiesantibacterial properties |
| spellingShingle | Zhang Qiuyang Zhang Li Yang Minhui Hong Qingxiang Yang Zhongmei Liu Sen Xiong Qingping Pan Changjiang Construction of Chi(Zn/BMP2)/HA composite coating on AZ31B magnesium alloy surface to improve the corrosion resistance and biocompatibility Nanotechnology Reviews magnesium alloy multifunctional composite coatings corrosion resistance biocompatibilities antibacterial properties |
| title | Construction of Chi(Zn/BMP2)/HA composite coating on AZ31B magnesium alloy surface to improve the corrosion resistance and biocompatibility |
| title_full | Construction of Chi(Zn/BMP2)/HA composite coating on AZ31B magnesium alloy surface to improve the corrosion resistance and biocompatibility |
| title_fullStr | Construction of Chi(Zn/BMP2)/HA composite coating on AZ31B magnesium alloy surface to improve the corrosion resistance and biocompatibility |
| title_full_unstemmed | Construction of Chi(Zn/BMP2)/HA composite coating on AZ31B magnesium alloy surface to improve the corrosion resistance and biocompatibility |
| title_short | Construction of Chi(Zn/BMP2)/HA composite coating on AZ31B magnesium alloy surface to improve the corrosion resistance and biocompatibility |
| title_sort | construction of chi zn bmp2 ha composite coating on az31b magnesium alloy surface to improve the corrosion resistance and biocompatibility |
| topic | magnesium alloy multifunctional composite coatings corrosion resistance biocompatibilities antibacterial properties |
| url | https://doi.org/10.1515/ntrev-2021-0063 |
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