Rates of Primary and Secondary Prevention of Cervical Cancer: A Study in a Province in the South of Italy
In Italy, cervical cancer represents the fifth most prevalent cancer in women under 50 years of age and is one of the most commonly detected lesions globally. Given the developing burden of the disease and the availability of both primary and secondary prevention measures, their accurate surveillanc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/11/1688 |
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| author | Miriam Gorgone Andrea Squeri Sara Cuffari Vincenza La Fauci Ioselita Giunta Serena Calderone Raffaele Squeri Cristina Genovese |
| author_facet | Miriam Gorgone Andrea Squeri Sara Cuffari Vincenza La Fauci Ioselita Giunta Serena Calderone Raffaele Squeri Cristina Genovese |
| author_sort | Miriam Gorgone |
| collection | DOAJ |
| description | In Italy, cervical cancer represents the fifth most prevalent cancer in women under 50 years of age and is one of the most commonly detected lesions globally. Given the developing burden of the disease and the availability of both primary and secondary prevention measures, their accurate surveillance is of paramount importance. The aim of this study was to evaluate the trends in cervical cancer screening adherence in the period between 2020 and 2022, as well as to evaluate positive tests, identifying the most frequently associated genotypes and the vaccination coverage. The study sample was made up of 6880 women from the health district of Messina. We highlighted that there was a high proportion of positive results in the investigated period, with a high prevalence of HSIL. Moreover, HPV vaccination coverage was clearly inadequate, as was adherence to screening, both far away from WHO goals. This finding is probably linked to inadequate communication and awareness of the issue in the population and to the lack of data relating to tests carried out privately. In accordance with existing data in the literature, the introduction of the HPV-DNA test in Sicily made it possible to identify women positive for the genotypes most frequently involved in the etiopathogenesis of neoplastic lesions (genotypes 16 and 18), as well as for those in the “others” category, which should be investigated because some of them could have an impact on carcinogenicity and, for this reason, a future vaccine including them could represent a new prevention weapon. |
| first_indexed | 2024-03-09T16:23:36Z |
| format | Article |
| id | doaj.art-62c54e17442d446ca7fa53ab4e4a1da0 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T16:23:36Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-62c54e17442d446ca7fa53ab4e4a1da02023-11-24T15:10:06ZengMDPI AGVaccines2076-393X2023-11-011111168810.3390/vaccines11111688Rates of Primary and Secondary Prevention of Cervical Cancer: A Study in a Province in the South of ItalyMiriam Gorgone0Andrea Squeri1Sara Cuffari2Vincenza La Fauci3Ioselita Giunta4Serena Calderone5Raffaele Squeri6Cristina Genovese7Department of Biomedical and Dental Sciences and Morpho Functional Imaging, Postgraduate Medical School of Preventive Medicine and Hygiene, University of Messina, 98121 Messina, ItalyMedical Oncology Unit, Department of Human Pathology “G. Barresi”, University of Messina, 98122 Messina, ItalyLocal Health Unit of Messina, 98123 Messina, ItalyDepartment of Biomedical and Dental Sciences and Morpho Functional Imaging, University of Messina, 98124 Messina, ItalyDepartment of Biomedical and Dental Sciences and Morpho Functional Imaging, Postgraduate Medical School of Preventive Medicine and Hygiene, University of Messina, 98121 Messina, ItalyDepartment of Biomedical and Dental Sciences and Morpho Functional Imaging, Postgraduate Medical School of Preventive Medicine and Hygiene, University of Messina, 98121 Messina, ItalyDepartment of Biomedical and Dental Sciences and Morpho Functional Imaging, University of Messina, 98124 Messina, ItalyLocal Health Unit of Messina, 98123 Messina, ItalyIn Italy, cervical cancer represents the fifth most prevalent cancer in women under 50 years of age and is one of the most commonly detected lesions globally. Given the developing burden of the disease and the availability of both primary and secondary prevention measures, their accurate surveillance is of paramount importance. The aim of this study was to evaluate the trends in cervical cancer screening adherence in the period between 2020 and 2022, as well as to evaluate positive tests, identifying the most frequently associated genotypes and the vaccination coverage. The study sample was made up of 6880 women from the health district of Messina. We highlighted that there was a high proportion of positive results in the investigated period, with a high prevalence of HSIL. Moreover, HPV vaccination coverage was clearly inadequate, as was adherence to screening, both far away from WHO goals. This finding is probably linked to inadequate communication and awareness of the issue in the population and to the lack of data relating to tests carried out privately. In accordance with existing data in the literature, the introduction of the HPV-DNA test in Sicily made it possible to identify women positive for the genotypes most frequently involved in the etiopathogenesis of neoplastic lesions (genotypes 16 and 18), as well as for those in the “others” category, which should be investigated because some of them could have an impact on carcinogenicity and, for this reason, a future vaccine including them could represent a new prevention weapon.https://www.mdpi.com/2076-393X/11/11/1688cervical cancerHPVvaccinepreventionPAP testscreening |
| spellingShingle | Miriam Gorgone Andrea Squeri Sara Cuffari Vincenza La Fauci Ioselita Giunta Serena Calderone Raffaele Squeri Cristina Genovese Rates of Primary and Secondary Prevention of Cervical Cancer: A Study in a Province in the South of Italy Vaccines cervical cancer HPV vaccine prevention PAP test screening |
| title | Rates of Primary and Secondary Prevention of Cervical Cancer: A Study in a Province in the South of Italy |
| title_full | Rates of Primary and Secondary Prevention of Cervical Cancer: A Study in a Province in the South of Italy |
| title_fullStr | Rates of Primary and Secondary Prevention of Cervical Cancer: A Study in a Province in the South of Italy |
| title_full_unstemmed | Rates of Primary and Secondary Prevention of Cervical Cancer: A Study in a Province in the South of Italy |
| title_short | Rates of Primary and Secondary Prevention of Cervical Cancer: A Study in a Province in the South of Italy |
| title_sort | rates of primary and secondary prevention of cervical cancer a study in a province in the south of italy |
| topic | cervical cancer HPV vaccine prevention PAP test screening |
| url | https://www.mdpi.com/2076-393X/11/11/1688 |
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