Improvement of diagnostic accuracy of Parkinson's disease on I-123-ioflupane single photon emission computed tomography (123I FP-CIT SPECT) using new Japanese normal database
<strong><em>Objective(s):</em></strong> I-123-ioflupane single photon emission computed tomography (FP-CIT-SPECT) has been used to assess dopamine transporter (DAT) loss in Parkinson's disease. The specific binding ratio (SBR), a quantitative parameter of DAT density in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2020-07-01
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| Series: | Asia Oceania Journal of Nuclear Medicine and Biology |
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| Online Access: | http://aojnmb.mums.ac.ir/article_15054_7adb0d762c38c07338b062a299a7e065.pdf |
| _version_ | 1828762067809599488 |
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| author | Takao Kanzaki Tetsuya Higuchi Yasuyuki Takahashi Takayuki Suto Yoshito Tsushima |
| author_facet | Takao Kanzaki Tetsuya Higuchi Yasuyuki Takahashi Takayuki Suto Yoshito Tsushima |
| author_sort | Takao Kanzaki |
| collection | DOAJ |
| description | <strong><em>Objective(s):</em></strong> I-123-ioflupane single photon emission computed tomography (FP-CIT-SPECT) has been used to assess dopamine transporter (DAT) loss in Parkinson's disease. The specific binding ratio (SBR), a quantitative parameter of DAT density in the striatum, may be affected by differences in age, sex, and SPECT system. The purpose of this study was to evaluate the utility of FP-CIT-SPECT using the Japanese normal database (NDB) in the diagnosis of Parkinson's disease.<br /> <strong><em>Methods: </em></strong>To standardize the quantitative outcome measures of DAT density obtained with different SPECT systems, striatal phantoms filled with striatal to background materials at ratios between 8:1 and 1:1 were measured using a gamma camera (ECAM) in our institute. Consecutive fifty patients (23 men and 27 women; age range, 40-86 years) with suspected PD undergoing FP-CIT SPECT brain imaging during the period from April to October 2016 were enrolled in this retrospective study. Their final diagnoses were PD in 28 patients and PD in 22 patients. SBRs of the patients were calculated using either new (Japanese database with different age and sex; NEWver) or old (non-Japanese database not specifying age and sex; OLDver) version software (AZE Virtual Place Hayabusa [DaTView], AZE, Ltd. Tokyo, Japan). The McNemar test was used to compare the diagnostic accuracy between old and new versions.<br /> <strong><em>R</em></strong><strong><em>esults</em></strong><em>: </em>Based on the phantom study, the calibrated SBR could be calculated by Y=1.25×Measured SBR+0.78. The sensitivities for OLDver and NEWver were 100% and 93%, respectively (p=0.5), and the specificities were 55% and 100% (p=0.002). The diagnostic accuracy of NEWver (96%) was better than that of OLDver (80%, p<0.001). <br /> <strong><em>Conclusion: </em></strong>FP-CIT-SPECT using the Japanese NDB improved the diagnostic accuracy of PD by improving specificity. |
| first_indexed | 2024-12-11T01:38:45Z |
| format | Article |
| id | doaj.art-62c553907985482bb439c305fd696410 |
| institution | Directory Open Access Journal |
| issn | 2322-5718 2322-5726 |
| language | English |
| last_indexed | 2024-12-11T01:38:45Z |
| publishDate | 2020-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Asia Oceania Journal of Nuclear Medicine and Biology |
| spelling | doaj.art-62c553907985482bb439c305fd6964102022-12-22T01:25:07ZengMashhad University of Medical SciencesAsia Oceania Journal of Nuclear Medicine and Biology2322-57182322-57262020-07-01829510110.22038/aojnmb.2019.43685.129015054Improvement of diagnostic accuracy of Parkinson's disease on I-123-ioflupane single photon emission computed tomography (123I FP-CIT SPECT) using new Japanese normal databaseTakao Kanzaki0Tetsuya Higuchi1Yasuyuki Takahashi2Takayuki Suto3Yoshito Tsushima4Department of Radiology, Gunma University Hospital, Gunma, JapanDepartment of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Gunma, JapanDepartment of Nuclear Medicine Technology, Hirosaki University Graduate School of Health Sciences, Hirosaki, JapanDepartment of Radiology, Gunma University Hospital, Gunma, JapanDepartment of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Gunma, Japan<strong><em>Objective(s):</em></strong> I-123-ioflupane single photon emission computed tomography (FP-CIT-SPECT) has been used to assess dopamine transporter (DAT) loss in Parkinson's disease. The specific binding ratio (SBR), a quantitative parameter of DAT density in the striatum, may be affected by differences in age, sex, and SPECT system. The purpose of this study was to evaluate the utility of FP-CIT-SPECT using the Japanese normal database (NDB) in the diagnosis of Parkinson's disease.<br /> <strong><em>Methods: </em></strong>To standardize the quantitative outcome measures of DAT density obtained with different SPECT systems, striatal phantoms filled with striatal to background materials at ratios between 8:1 and 1:1 were measured using a gamma camera (ECAM) in our institute. Consecutive fifty patients (23 men and 27 women; age range, 40-86 years) with suspected PD undergoing FP-CIT SPECT brain imaging during the period from April to October 2016 were enrolled in this retrospective study. Their final diagnoses were PD in 28 patients and PD in 22 patients. SBRs of the patients were calculated using either new (Japanese database with different age and sex; NEWver) or old (non-Japanese database not specifying age and sex; OLDver) version software (AZE Virtual Place Hayabusa [DaTView], AZE, Ltd. Tokyo, Japan). The McNemar test was used to compare the diagnostic accuracy between old and new versions.<br /> <strong><em>R</em></strong><strong><em>esults</em></strong><em>: </em>Based on the phantom study, the calibrated SBR could be calculated by Y=1.25×Measured SBR+0.78. The sensitivities for OLDver and NEWver were 100% and 93%, respectively (p=0.5), and the specificities were 55% and 100% (p=0.002). The diagnostic accuracy of NEWver (96%) was better than that of OLDver (80%, p<0.001). <br /> <strong><em>Conclusion: </em></strong>FP-CIT-SPECT using the Japanese NDB improved the diagnostic accuracy of PD by improving specificity.http://aojnmb.mums.ac.ir/article_15054_7adb0d762c38c07338b062a299a7e065.pdfjapanese normal databaseparkinson's diseasedat scanspecific binding ratio |
| spellingShingle | Takao Kanzaki Tetsuya Higuchi Yasuyuki Takahashi Takayuki Suto Yoshito Tsushima Improvement of diagnostic accuracy of Parkinson's disease on I-123-ioflupane single photon emission computed tomography (123I FP-CIT SPECT) using new Japanese normal database Asia Oceania Journal of Nuclear Medicine and Biology japanese normal database parkinson's disease dat scan specific binding ratio |
| title | Improvement of diagnostic accuracy of Parkinson's disease on I-123-ioflupane single photon emission computed tomography (123I FP-CIT SPECT) using new Japanese normal database |
| title_full | Improvement of diagnostic accuracy of Parkinson's disease on I-123-ioflupane single photon emission computed tomography (123I FP-CIT SPECT) using new Japanese normal database |
| title_fullStr | Improvement of diagnostic accuracy of Parkinson's disease on I-123-ioflupane single photon emission computed tomography (123I FP-CIT SPECT) using new Japanese normal database |
| title_full_unstemmed | Improvement of diagnostic accuracy of Parkinson's disease on I-123-ioflupane single photon emission computed tomography (123I FP-CIT SPECT) using new Japanese normal database |
| title_short | Improvement of diagnostic accuracy of Parkinson's disease on I-123-ioflupane single photon emission computed tomography (123I FP-CIT SPECT) using new Japanese normal database |
| title_sort | improvement of diagnostic accuracy of parkinson s disease on i 123 ioflupane single photon emission computed tomography 123i fp cit spect using new japanese normal database |
| topic | japanese normal database parkinson's disease dat scan specific binding ratio |
| url | http://aojnmb.mums.ac.ir/article_15054_7adb0d762c38c07338b062a299a7e065.pdf |
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