Remodeling in Persistent Atrial Fibrillation: Pathophysiology and Therapeutic Targets—A Systematic Review
Atrial fibrillation (AF) is characterized by disorganized rapid atrial electrical activity, which leads to impaired atrial function, adverse hemodynamic effects, and increased thromboembolic risk. The paroxysmal forms of AF can be effectively treated with current pharmacological and non-pharmacologi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Physiologia |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-9488/3/1/4 |
| _version_ | 1797609426091245568 |
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| author | Attila Roka Isaac Burright |
| author_facet | Attila Roka Isaac Burright |
| author_sort | Attila Roka |
| collection | DOAJ |
| description | Atrial fibrillation (AF) is characterized by disorganized rapid atrial electrical activity, which leads to impaired atrial function, adverse hemodynamic effects, and increased thromboembolic risk. The paroxysmal forms of AF can be effectively treated with current pharmacological and non-pharmacological modalities by targeting the arrhythmia triggers. Persistent AF, however, is more difficult to treat due to remodeling processes which may become major factors in the maintenance of the arrhythmia, rendering trigger-targeting treatment options less effective. We will systematically review the recent findings of the development and maintenance of persistent AF, including genetic, cellular, organ level, and systemic processes. As AF remains the most common sustained arrhythmia with the ongoing need to find effective treatment, we will also discuss potential treatment options targeting the remodeling processes. |
| first_indexed | 2024-03-11T06:01:11Z |
| format | Article |
| id | doaj.art-62c69e949f9c4b3c8656348810b41138 |
| institution | Directory Open Access Journal |
| issn | 2673-9488 |
| language | English |
| last_indexed | 2024-03-11T06:01:11Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Physiologia |
| spelling | doaj.art-62c69e949f9c4b3c8656348810b411382023-11-17T13:20:27ZengMDPI AGPhysiologia2673-94882023-01-0131437210.3390/physiologia3010004Remodeling in Persistent Atrial Fibrillation: Pathophysiology and Therapeutic Targets—A Systematic ReviewAttila Roka0Isaac Burright1Division of Cardiology, Creighton University and CHI Health, 7500 Mercy Rd, Omaha, NE 68124, USADivision of Cardiology, Creighton University and CHI Health, 7500 Mercy Rd, Omaha, NE 68124, USAAtrial fibrillation (AF) is characterized by disorganized rapid atrial electrical activity, which leads to impaired atrial function, adverse hemodynamic effects, and increased thromboembolic risk. The paroxysmal forms of AF can be effectively treated with current pharmacological and non-pharmacological modalities by targeting the arrhythmia triggers. Persistent AF, however, is more difficult to treat due to remodeling processes which may become major factors in the maintenance of the arrhythmia, rendering trigger-targeting treatment options less effective. We will systematically review the recent findings of the development and maintenance of persistent AF, including genetic, cellular, organ level, and systemic processes. As AF remains the most common sustained arrhythmia with the ongoing need to find effective treatment, we will also discuss potential treatment options targeting the remodeling processes.https://www.mdpi.com/2673-9488/3/1/4persistent atrial fibrillationremodelingpathophysiologyupstream therapybiomarkers |
| spellingShingle | Attila Roka Isaac Burright Remodeling in Persistent Atrial Fibrillation: Pathophysiology and Therapeutic Targets—A Systematic Review Physiologia persistent atrial fibrillation remodeling pathophysiology upstream therapy biomarkers |
| title | Remodeling in Persistent Atrial Fibrillation: Pathophysiology and Therapeutic Targets—A Systematic Review |
| title_full | Remodeling in Persistent Atrial Fibrillation: Pathophysiology and Therapeutic Targets—A Systematic Review |
| title_fullStr | Remodeling in Persistent Atrial Fibrillation: Pathophysiology and Therapeutic Targets—A Systematic Review |
| title_full_unstemmed | Remodeling in Persistent Atrial Fibrillation: Pathophysiology and Therapeutic Targets—A Systematic Review |
| title_short | Remodeling in Persistent Atrial Fibrillation: Pathophysiology and Therapeutic Targets—A Systematic Review |
| title_sort | remodeling in persistent atrial fibrillation pathophysiology and therapeutic targets a systematic review |
| topic | persistent atrial fibrillation remodeling pathophysiology upstream therapy biomarkers |
| url | https://www.mdpi.com/2673-9488/3/1/4 |
| work_keys_str_mv | AT attilaroka remodelinginpersistentatrialfibrillationpathophysiologyandtherapeutictargetsasystematicreview AT isaacburright remodelinginpersistentatrialfibrillationpathophysiologyandtherapeutictargetsasystematicreview |