Phytochemical based nanomedicine: a panacea for cancer treatment, present status and future prospective
Cancer is one of the leading causes of mortality worldwide. Currently available anticancer therapeutic strategies are not able to improve the survival rate of patients over the past few decades. Research suggests that cancer cells develop multidrug resistance (MDR) against chemotherapeutics that lea...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | OpenNano |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352952022000184 |
| _version_ | 1798037586442190848 |
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| author | Priyanka Mohapatra Priya Singh Deepika Singh Sonali Sahoo Sanjeeb Kumar Sahoo |
| author_facet | Priyanka Mohapatra Priya Singh Deepika Singh Sonali Sahoo Sanjeeb Kumar Sahoo |
| author_sort | Priyanka Mohapatra |
| collection | DOAJ |
| description | Cancer is one of the leading causes of mortality worldwide. Currently available anticancer therapeutic strategies are not able to improve the survival rate of patients over the past few decades. Research suggests that cancer cells develop multidrug resistance (MDR) against chemotherapeutics that lead to enhanced proliferation, epithelial to mesenchymal transition (EMT), invasion and metastasis. Hence, there is an urgent need for an alternative strategy to treat this disease. Recently, phytochemicals have gained immense attention as a promising anticancer agent by targeting multimodal oncogenic pathways, inducing cell cycle arrest and apoptosis in preclinical studies. However, their clinical application is limited due to poor aqueous solubility, poor bioavailability, low cellular uptake and narrow therapeutic index. Therefore, to address these challenges, phytochemical-based nanomedicine i.e. phytonanomedicine have been developed that can improve pharmacokinetics profile in in vivo systems. In this review, we aim to summarize challenges in cancer treatment and the status of phytonanomedicine for effective cancer treatment in preclinical and clinical studies. |
| first_indexed | 2024-04-11T21:28:34Z |
| format | Article |
| id | doaj.art-62c84dcf671f4e5086e0dbdb9ac14693 |
| institution | Directory Open Access Journal |
| issn | 2352-9520 |
| language | English |
| last_indexed | 2024-04-11T21:28:34Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | OpenNano |
| spelling | doaj.art-62c84dcf671f4e5086e0dbdb9ac146932022-12-22T04:02:16ZengElsevierOpenNano2352-95202022-07-017100055Phytochemical based nanomedicine: a panacea for cancer treatment, present status and future prospectivePriyanka Mohapatra0Priya Singh1Deepika Singh2Sonali Sahoo3Sanjeeb Kumar Sahoo4Institute of Life Sciences, Nalco Square, Bhubaneswar, Odisha, India; Regional Centre for Biotechnology, Faridabad, Haryana (NCR Delhi), IndiaInstitute of Life Sciences, Nalco Square, Bhubaneswar, Odisha, India; Regional Centre for Biotechnology, Faridabad, Haryana (NCR Delhi), IndiaInstitute of Life Sciences, Nalco Square, Bhubaneswar, Odisha, IndiaInstitute of Life Sciences, Nalco Square, Bhubaneswar, Odisha, India; Regional Centre for Biotechnology, Faridabad, Haryana (NCR Delhi), IndiaInstitute of Life Sciences, Nalco Square, Bhubaneswar, Odisha, India; Corresponding author.Cancer is one of the leading causes of mortality worldwide. Currently available anticancer therapeutic strategies are not able to improve the survival rate of patients over the past few decades. Research suggests that cancer cells develop multidrug resistance (MDR) against chemotherapeutics that lead to enhanced proliferation, epithelial to mesenchymal transition (EMT), invasion and metastasis. Hence, there is an urgent need for an alternative strategy to treat this disease. Recently, phytochemicals have gained immense attention as a promising anticancer agent by targeting multimodal oncogenic pathways, inducing cell cycle arrest and apoptosis in preclinical studies. However, their clinical application is limited due to poor aqueous solubility, poor bioavailability, low cellular uptake and narrow therapeutic index. Therefore, to address these challenges, phytochemical-based nanomedicine i.e. phytonanomedicine have been developed that can improve pharmacokinetics profile in in vivo systems. In this review, we aim to summarize challenges in cancer treatment and the status of phytonanomedicine for effective cancer treatment in preclinical and clinical studies.http://www.sciencedirect.com/science/article/pii/S2352952022000184CancerDrug resistancePhytochemicalNanomedicinePhytonanomedicine |
| spellingShingle | Priyanka Mohapatra Priya Singh Deepika Singh Sonali Sahoo Sanjeeb Kumar Sahoo Phytochemical based nanomedicine: a panacea for cancer treatment, present status and future prospective OpenNano Cancer Drug resistance Phytochemical Nanomedicine Phytonanomedicine |
| title | Phytochemical based nanomedicine: a panacea for cancer treatment, present status and future prospective |
| title_full | Phytochemical based nanomedicine: a panacea for cancer treatment, present status and future prospective |
| title_fullStr | Phytochemical based nanomedicine: a panacea for cancer treatment, present status and future prospective |
| title_full_unstemmed | Phytochemical based nanomedicine: a panacea for cancer treatment, present status and future prospective |
| title_short | Phytochemical based nanomedicine: a panacea for cancer treatment, present status and future prospective |
| title_sort | phytochemical based nanomedicine a panacea for cancer treatment present status and future prospective |
| topic | Cancer Drug resistance Phytochemical Nanomedicine Phytonanomedicine |
| url | http://www.sciencedirect.com/science/article/pii/S2352952022000184 |
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