Interleukin-6 on postoperative day three as an early predictor of infections following laparoscopic gastric cancer resection
Abstract Background To investigate the role of C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) as early predictors of infectious complications after laparoscopic gastric cancer surgery. Methods Patients who underwent laparoscopic gastric cancer surgery between January 2020 an...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | BMC Surgery |
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| Online Access: | https://doi.org/10.1186/s12893-024-02381-8 |
| _version_ | 1797247470853423104 |
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| author | Yongzhou Huang Lei Yang Wenchang Yang Pei Zhou Qi Jiang Weizhen Liu Yuping Yin Xiangyu Zeng Peng Zhang Kaixiong Tao |
| author_facet | Yongzhou Huang Lei Yang Wenchang Yang Pei Zhou Qi Jiang Weizhen Liu Yuping Yin Xiangyu Zeng Peng Zhang Kaixiong Tao |
| author_sort | Yongzhou Huang |
| collection | DOAJ |
| description | Abstract Background To investigate the role of C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) as early predictors of infectious complications after laparoscopic gastric cancer surgery. Methods Patients who underwent laparoscopic gastric cancer surgery between January 2020 and June 2022 were retrospectively enrolled. IL-6, PCT, and CRP levels were assessed before surgery and on postoperative days (PODs) 3 and 5. Differences in serum IL-6, PCT, and CRP levels between the infected and non-infected groups were compared. The diagnostic accuracy was determined using the area under the receiver operating characteristic curve (AUC). Results A total of 206 patients were enrolled, and 21 patients (10.19%) developed postoperative infections. Serum IL-6, PCT, and CRP levels in the infected group were significantly higher than those in the non-infected group on PODs 3 and 5. IL-6 with an optimal cutoff value of 84.00 pg/mL (AUC 0.84), PCT with an optimal cutoff value of 1.39 ng/mL (AUC 0.80), CRP with an optimal cutoff value of 150.00 mg/L (AUC 0.76) on POD 3 had superior diagnostic accuracy in predicting postoperative infections. Multivariate analysis identified PCT and IL-6 levels on POD 3 as independent risk factors, the AUC of the combination of IL-6 and PCT was 0.89. The Delong test showed no difference between the AUC of IL-6 alone and IL-6 combined with PCT prediction (P = 0.07, Z = 1.81). Conclusions IL-6 level on POD 3 is an excellent predictor of infectious complications following laparoscopic gastric cancer surgery. Patients with IL-6 levels lower than 84.00 pg/mL on POD 3 can ensure safe early discharge with a low probability of infection. |
| first_indexed | 2024-04-24T19:59:13Z |
| format | Article |
| id | doaj.art-62c8f7cbeeb542e7a9b054e325f1538c |
| institution | Directory Open Access Journal |
| issn | 1471-2482 |
| language | English |
| last_indexed | 2024-04-24T19:59:13Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Surgery |
| spelling | doaj.art-62c8f7cbeeb542e7a9b054e325f1538c2024-03-24T12:09:06ZengBMCBMC Surgery1471-24822024-03-012411910.1186/s12893-024-02381-8Interleukin-6 on postoperative day three as an early predictor of infections following laparoscopic gastric cancer resectionYongzhou Huang0Lei Yang1Wenchang Yang2Pei Zhou3Qi Jiang4Weizhen Liu5Yuping Yin6Xiangyu Zeng7Peng Zhang8Kaixiong Tao9Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Background To investigate the role of C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) as early predictors of infectious complications after laparoscopic gastric cancer surgery. Methods Patients who underwent laparoscopic gastric cancer surgery between January 2020 and June 2022 were retrospectively enrolled. IL-6, PCT, and CRP levels were assessed before surgery and on postoperative days (PODs) 3 and 5. Differences in serum IL-6, PCT, and CRP levels between the infected and non-infected groups were compared. The diagnostic accuracy was determined using the area under the receiver operating characteristic curve (AUC). Results A total of 206 patients were enrolled, and 21 patients (10.19%) developed postoperative infections. Serum IL-6, PCT, and CRP levels in the infected group were significantly higher than those in the non-infected group on PODs 3 and 5. IL-6 with an optimal cutoff value of 84.00 pg/mL (AUC 0.84), PCT with an optimal cutoff value of 1.39 ng/mL (AUC 0.80), CRP with an optimal cutoff value of 150.00 mg/L (AUC 0.76) on POD 3 had superior diagnostic accuracy in predicting postoperative infections. Multivariate analysis identified PCT and IL-6 levels on POD 3 as independent risk factors, the AUC of the combination of IL-6 and PCT was 0.89. The Delong test showed no difference between the AUC of IL-6 alone and IL-6 combined with PCT prediction (P = 0.07, Z = 1.81). Conclusions IL-6 level on POD 3 is an excellent predictor of infectious complications following laparoscopic gastric cancer surgery. Patients with IL-6 levels lower than 84.00 pg/mL on POD 3 can ensure safe early discharge with a low probability of infection.https://doi.org/10.1186/s12893-024-02381-8Interleukin-6ProcalcitoninC-reactive proteinGastric cancerPostoperative complications |
| spellingShingle | Yongzhou Huang Lei Yang Wenchang Yang Pei Zhou Qi Jiang Weizhen Liu Yuping Yin Xiangyu Zeng Peng Zhang Kaixiong Tao Interleukin-6 on postoperative day three as an early predictor of infections following laparoscopic gastric cancer resection BMC Surgery Interleukin-6 Procalcitonin C-reactive protein Gastric cancer Postoperative complications |
| title | Interleukin-6 on postoperative day three as an early predictor of infections following laparoscopic gastric cancer resection |
| title_full | Interleukin-6 on postoperative day three as an early predictor of infections following laparoscopic gastric cancer resection |
| title_fullStr | Interleukin-6 on postoperative day three as an early predictor of infections following laparoscopic gastric cancer resection |
| title_full_unstemmed | Interleukin-6 on postoperative day three as an early predictor of infections following laparoscopic gastric cancer resection |
| title_short | Interleukin-6 on postoperative day three as an early predictor of infections following laparoscopic gastric cancer resection |
| title_sort | interleukin 6 on postoperative day three as an early predictor of infections following laparoscopic gastric cancer resection |
| topic | Interleukin-6 Procalcitonin C-reactive protein Gastric cancer Postoperative complications |
| url | https://doi.org/10.1186/s12893-024-02381-8 |
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