Pleiotropic Effect of a High Resolution Mapped Blood Pressure QTL on Tumorigenesis.

Pleiotropic Effect of a High Resolution Mapped Blood Pressure QTL on Tumorigenesis.

This study is focused on a translationally significant, genome-wide-association-study (GWAS) locus for cardiovascular disease (QT-interval) on human chromosome 17. We have previously validated and high resolution mapped the homologous genomic segment of this human locus to <42.5 kb on rat chromos...

Full description

Bibliographic Details
Main Authors:	Xi Cheng, Harshal Waghulde, Blair Mell, Kathryn Smedlund, Guillermo Vazquez, Bina Joe
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2016-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4830557?pdf=render

Similar Items

QTL mapping of rat blood pressure loci on RNO1 within a homologous region linked to human hypertension on HSA15.
by: Blair Mell, et al.
Published: (2019-01-01)

Positional cloning of quantitative trait nucleotides for blood pressure and cardiac QT-interval by targeted CRISPR/Cas9 editing of a novel long non-coding RNA.
by: Xi Cheng, et al.
Published: (2017-08-01)

Dissection of Pleiotropic QTL Regions Controlling Wheat Spike Characteristics Under Different Nitrogen Treatments Using Traditional and Conditional QTL Mapping
by: Xiaoli Fan, et al.
Published: (2019-02-01)

A new approach to detect non-pleiotropic QTL for correlated traits
by: A. Carta, et al.
Published: (2010-01-01)

A Bayesian partition method for detecting pleiotropic and epistatic eQTL modules.
by: Wei Zhang, et al.
Published: (2010-01-01)

Fine Mapping of a Major Pleiotropic QTL Associated with Sesamin and Sesamolin Variation in Sesame (<i>Sesamum indicum</i> L.)
by: Fangtao Xu, et al.
Published: (2021-06-01)

QTL Mapping for Agronomic and Adaptive Traits Confirmed Pleiotropic Effect of mog Gene in Black Gram [Vigna mungo (L.) Hepper]
by: Prakit Somta, et al.
Published: (2020-06-01)

Pleiotropic effect of sodium-glucose cotransporter 2 inhibitors on blood pressure
by: Ting-Wei Kao, et al.
Published: (2022-12-01)

Ivabradine and Blood Pressure Reduction: Underlying Pleiotropic Mechanisms and Clinical Implications
by: Fedor Simko, et al.
Published: (2021-02-01)

β-catenin functions pleiotropically in differentiation and tumorigenesis in mouse embryo-derived stem cells.
by: Noriko Okumura, et al.
Published: (2013-01-01)

Exposure to Amoxicillin in Early Life Is Associated With Changes in Gut Microbiota and Reduction in Blood Pressure: Findings From a Study on Rat Dams and Offspring
by: Sarah Galla, et al.
Published: (2020-01-01)

Gene by environment QTL mapping through multiple trait analyses in blood pressure salt-sensitivity: identification of a novel QTL in rat chromosome 5
by: Tôrres César H, et al.
Published: (2006-05-01)

A pleiotropic QTL increased economic water use efficiency in bread wheat (Triticum aestivum L.)
by: Jian Hui, et al.
Published: (2023-01-01)

Congenic Strains Confirm the Pleiotropic Effect of Chromosome 4 QTL on Mouse Femoral Geometry and Biomechanical Performance.
by: Jasmin Kristianto, et al.
Published: (2016-01-01)

Whole-organism eQTL mapping at cellular resolution with single-cell sequencing
by: Eyal Ben-David, et al.
Published: (2021-03-01)

High-Resolution Linkage Map and QTL Analyses of Fruit Firmness in Autotetraploid Blueberry
by: Francesco Cappai, et al.
Published: (2020-11-01)

Mendelian randomization integrating GWAS and eQTL data revealed genes pleiotropically associated with major depressive disorder
by: Huarong Yang, et al.
Published: (2021-04-01)

Pleiotropic analysis of lung cancer and blood triglycerides.
by: Zuber, V, et al.
Published: (2016)

Genome‐wide association mapping for pre‐harvest sprouting in European winter wheat detects novel resistance QTL, pleiotropic effects, and structural variation in multiple genomes
by: Hermann G. Dallinger, et al.
Published: (2024-03-01)

Genetic predisposition for increased red blood cell distribution width is an early risk factor for cardiovascular and renal comorbidities
by: Xi Cheng, et al.
Published: (2020-05-01)

Mapping of QTL affecting incidence of blood and meat inclusions in egg layers
by: Vennerström Pia, et al.
Published: (2011-06-01)

High-resolution genetic mapping of the ACE-linked QTL influencing circulating ACE activity.
by: Soubrier, F, et al.
Published: (2002)

Advances in QTL Mapping in Pigs
by: Max F. Rothschild, Zhi-liang Hu, Zhihua Jiang
Published: (2007-01-01)

The power of QTL mapping with RILs.
by: Shohei Takuno, et al.
Published: (2012-01-01)

Fine mapping of multiple QTL using combined linkage and linkage disequilibrium mapping – A comparison of single QTL and multi QTL methods
by: Meuwissen Theo HE, et al.
Published: (2007-04-01)

Novel QTL and Meta-QTL Mapping for Major Quality Traits in Soybean
by: Heng Chen, et al.
Published: (2021-12-01)

Cis-meQTL for cocaine use-associated DNA methylation in an HIV-positive cohort show pleiotropic effects on multiple traits
by: Youshu Cheng, et al.
Published: (2023-09-01)

Integration of eQTL and machine learning to dissect causal genes with pleiotropic effects in genetic regulation networks of seed cotton yield
by: Ting Zhao, et al.
Published: (2023-09-01)

Value Creation in the Internet of Things: Mapping Business Models and Ecosystem Roles
by: Heini Ikävalko, et al.
Published: (2018-03-01)

QTL mapping reveals candidate genes for main agronomic traits in Luffa based on a high-resolution genetic map
by: Lili Liu, et al.
Published: (2022-11-01)

High-resolution genetic linkage map of European pear (Pyrus communis) and QTL fine-mapping of vegetative budbreak time
by: Gilad Gabay, et al.
Published: (2018-08-01)

High resolution physical map of porcine chromosome 7 QTL region and comparative mapping of this region among vertebrate genomes
by: Demeure Olivier, et al.
Published: (2006-01-01)

A high-resolution linkage map for comparative genome analysis and QTL fine mapping in Asian seabass, <it>Lates calcarifer</it>
by: Feng Felicia, et al.
Published: (2011-04-01)

QTL mapping and BSA-seq map a major QTL for the node of the first fruiting branch in cotton
by: Xiaoyun Jia, et al.
Published: (2023-01-01)

Dissection of rat chromosome 1 blood pressure QTL region: Evidence for multiple loci
by: Frantz, S, et al.
Published: (2000)

Massive QTL analysis identifies pleiotropic genetic determinants for stress resistance, aroma formation, and ethanol, glycerol and isobutanol production in Saccharomyces cerevisiae
by: Ping-Wei Ho, et al.
Published: (2021-11-01)

The genetic architecture of phosphorus efficiency in sorghum involves pleiotropic QTL for root morphology and grain yield under low phosphorus availability in the soil
by: Karine C. Bernardino, et al.
Published: (2019-02-01)

Genetic and QTL mapping in African bermudagrass
by: Shuhao Yu, et al.
Published: (2021-03-01)

Integrative analysis of low- and high-resolution eQTL.
by: Salvatore Loguercio, et al.
Published: (2010-11-01)

qtl.outbred: Interfacing outbred line cross data with the R/qtl mapping software
by: Carlborg Örjan, et al.
Published: (2011-05-01)