Kinetic Release Studies of Antibiotic Patches for Local Transdermal Delivery
This study investigates the usage of electrohydrodynamic (EHD)-3D printing for the fabrication of bacterial cellulose (BC)/polycaprolactone (PCL) patches loaded with different antibiotics (amoxicillin (AMX), ampicillin (AMP), and kanamycin (KAN)) for transdermal delivery. The composite patches demon...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/13/5/613 |
| _version_ | 1797536517054267392 |
|---|---|
| author | Esra Altun Esra Yuca Nazmi Ekren Deepak M. Kalaskar Denisa Ficai Georgiana Dolete Anton Ficai Oguzhan Gunduz |
| author_facet | Esra Altun Esra Yuca Nazmi Ekren Deepak M. Kalaskar Denisa Ficai Georgiana Dolete Anton Ficai Oguzhan Gunduz |
| author_sort | Esra Altun |
| collection | DOAJ |
| description | This study investigates the usage of electrohydrodynamic (EHD)-3D printing for the fabrication of bacterial cellulose (BC)/polycaprolactone (PCL) patches loaded with different antibiotics (amoxicillin (AMX), ampicillin (AMP), and kanamycin (KAN)) for transdermal delivery. The composite patches demonstrated facilitated drug loading and encapsulation efficiency of drugs along with extended drug release profiles. Release curves were also subjected to model fitting, and it was found that drug release was optimally adapted to the Higuchi square root model for each drug. They performed a time-dependent and diffusion-controlled release from the patches and followed Fick’s diffusion law by the Korsmeyer–Peppas energy law equation. Moreover, produced patches demonstrated excellent antimicrobial activity against Gram-positive (<i>Staphylococcus aureus</i>) and Gram-negative (<i>Escherichia coli</i>) strains, so they could be helpful in the treatment of chronic infectious lesions during wound closures. As different tests have confirmed, various types of antibiotics could be loaded and successfully released regardless of their types from produced BC/PCL patches. This study could breathe life into the production of antibiotic patches for local transdermal applications in wound dressing studies and improve the quality of life of patients. |
| first_indexed | 2024-03-10T12:01:50Z |
| format | Article |
| id | doaj.art-62ca7dbafc4b428d95501368f8ab781f |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T12:01:50Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-62ca7dbafc4b428d95501368f8ab781f2023-11-21T16:54:06ZengMDPI AGPharmaceutics1999-49232021-04-0113561310.3390/pharmaceutics13050613Kinetic Release Studies of Antibiotic Patches for Local Transdermal DeliveryEsra Altun0Esra Yuca1Nazmi Ekren2Deepak M. Kalaskar3Denisa Ficai4Georgiana Dolete5Anton Ficai6Oguzhan Gunduz7Centre for Nanotechnology & Biomaterials Research, Department of Metallurgical and Materials Engineering, Faculty of Technology, Goztepe Campus, Marmara University, Istanbul 34722, TurkeyDepartment of Molecular Biology and Genetics, Faculty of Arts and Sciences, Davutpasa Campus, Yildiz Technical University, Istanbul 34220, TurkeyCentre for Nanotechnology & Biomaterials Research, Department of Electrical-Electronics Engineering, Faculty of Technology, Goztepe Campus, Marmara University, Istanbul 34722, TurkeyUCL Division of Surgery and Interventional Science, Royal Free Hospital Campus, University College London, Rowland Hill Street, London NW3 2PF, UKDepartment of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, 060042 Bucharest, RomaniaNational Centre for Micro- and Nanomaterials, University POLITEHNICA of Bucharest, 060042 Bucharest, RomaniaNational Centre for Micro- and Nanomaterials, University POLITEHNICA of Bucharest, 060042 Bucharest, RomaniaCentre for Nanotechnology & Biomaterials Research, Department of Metallurgical and Materials Engineering, Faculty of Technology, Goztepe Campus, Marmara University, Istanbul 34722, TurkeyThis study investigates the usage of electrohydrodynamic (EHD)-3D printing for the fabrication of bacterial cellulose (BC)/polycaprolactone (PCL) patches loaded with different antibiotics (amoxicillin (AMX), ampicillin (AMP), and kanamycin (KAN)) for transdermal delivery. The composite patches demonstrated facilitated drug loading and encapsulation efficiency of drugs along with extended drug release profiles. Release curves were also subjected to model fitting, and it was found that drug release was optimally adapted to the Higuchi square root model for each drug. They performed a time-dependent and diffusion-controlled release from the patches and followed Fick’s diffusion law by the Korsmeyer–Peppas energy law equation. Moreover, produced patches demonstrated excellent antimicrobial activity against Gram-positive (<i>Staphylococcus aureus</i>) and Gram-negative (<i>Escherichia coli</i>) strains, so they could be helpful in the treatment of chronic infectious lesions during wound closures. As different tests have confirmed, various types of antibiotics could be loaded and successfully released regardless of their types from produced BC/PCL patches. This study could breathe life into the production of antibiotic patches for local transdermal applications in wound dressing studies and improve the quality of life of patients.https://www.mdpi.com/1999-4923/13/5/613electrohydrodynamic printingantibiotic patchesdrug releasepolymerbacterial cellulose |
| spellingShingle | Esra Altun Esra Yuca Nazmi Ekren Deepak M. Kalaskar Denisa Ficai Georgiana Dolete Anton Ficai Oguzhan Gunduz Kinetic Release Studies of Antibiotic Patches for Local Transdermal Delivery Pharmaceutics electrohydrodynamic printing antibiotic patches drug release polymer bacterial cellulose |
| title | Kinetic Release Studies of Antibiotic Patches for Local Transdermal Delivery |
| title_full | Kinetic Release Studies of Antibiotic Patches for Local Transdermal Delivery |
| title_fullStr | Kinetic Release Studies of Antibiotic Patches for Local Transdermal Delivery |
| title_full_unstemmed | Kinetic Release Studies of Antibiotic Patches for Local Transdermal Delivery |
| title_short | Kinetic Release Studies of Antibiotic Patches for Local Transdermal Delivery |
| title_sort | kinetic release studies of antibiotic patches for local transdermal delivery |
| topic | electrohydrodynamic printing antibiotic patches drug release polymer bacterial cellulose |
| url | https://www.mdpi.com/1999-4923/13/5/613 |
| work_keys_str_mv | AT esraaltun kineticreleasestudiesofantibioticpatchesforlocaltransdermaldelivery AT esrayuca kineticreleasestudiesofantibioticpatchesforlocaltransdermaldelivery AT nazmiekren kineticreleasestudiesofantibioticpatchesforlocaltransdermaldelivery AT deepakmkalaskar kineticreleasestudiesofantibioticpatchesforlocaltransdermaldelivery AT denisaficai kineticreleasestudiesofantibioticpatchesforlocaltransdermaldelivery AT georgianadolete kineticreleasestudiesofantibioticpatchesforlocaltransdermaldelivery AT antonficai kineticreleasestudiesofantibioticpatchesforlocaltransdermaldelivery AT oguzhangunduz kineticreleasestudiesofantibioticpatchesforlocaltransdermaldelivery |