Temporal muscle thickness has no prognostic relevance in patients with high-grade glioma compared to functional scales
BackgroundGBM research is constantly assessing potential valuable prognostic biomarkers to better understand the disease and prognosticate future outcomes. Measuring temporal muscle thickness (TMT) has appeared to be a promising new surrogate marker for skeletal muscle mass and sarcopenia, which fur...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1237105/full |
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| author | Julia Klingenschmid Aleksandrs Krigers Victoria Schön Daniel Pinggera Johannes Kerschbaumer Astrid E. Grams Claudius Thomé Christian F. Freyschlag |
| author_facet | Julia Klingenschmid Aleksandrs Krigers Victoria Schön Daniel Pinggera Johannes Kerschbaumer Astrid E. Grams Claudius Thomé Christian F. Freyschlag |
| author_sort | Julia Klingenschmid |
| collection | DOAJ |
| description | BackgroundGBM research is constantly assessing potential valuable prognostic biomarkers to better understand the disease and prognosticate future outcomes. Measuring temporal muscle thickness (TMT) has appeared to be a promising new surrogate marker for skeletal muscle mass and sarcopenia, which further indicates frailty and predicts overall survival (OS). The aim of this study was to determine its usefulness as a prognostic marker in patients with high-grade glioma compared to functional status scales.MethodsTMT was measured in preoperative axial T1-weighted contrast-enhanced magnetic resonance images in 277 patients who received surgical treatment of newly diagnosed WHO III and IV gliomas in our institution between 2015 and 2020. Clinical Frailty Scale (CFS) and Karnofsky Performance Scale (KPS) were assessed preoperatively and during a follow-up visit.ResultsFemale gender has shown significant correlation with TMT, while TMT did not correlate with preoperative and follow-up functional scores, age, WHO classification, IDH mutation, MGMT promoter methylation, EGFR and ATRX expression, or 1p/19q co-deletion. No significant prognostic value of TMT could be shown in 6, 12, and 24 months OS, while changes in CFS and KPS proved to have a significant impact.ConclusionOnly female gender, but no other clinical, histological, or molecular marker showed any interrelation with TMT. Functional scores outclass measuring TMT as a reliable prognostic factor for predicting OS in patients with high-grade glioma. |
| first_indexed | 2024-03-12T11:41:36Z |
| format | Article |
| id | doaj.art-62cb2ea7a7844787a0e6fcbd24a13460 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-12T11:41:36Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-62cb2ea7a7844787a0e6fcbd24a134602023-08-31T15:10:13ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-08-011310.3389/fonc.2023.12371051237105Temporal muscle thickness has no prognostic relevance in patients with high-grade glioma compared to functional scalesJulia Klingenschmid0Aleksandrs Krigers1Victoria Schön2Daniel Pinggera3Johannes Kerschbaumer4Astrid E. Grams5Claudius Thomé6Christian F. Freyschlag7Department of Neurosurgery, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Neurosurgery, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Neurosurgery, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Neurosurgery, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Neurosurgery, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Radiology, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Neurosurgery, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Neurosurgery, Medical University of Innsbruck, Innsbruck, AustriaBackgroundGBM research is constantly assessing potential valuable prognostic biomarkers to better understand the disease and prognosticate future outcomes. Measuring temporal muscle thickness (TMT) has appeared to be a promising new surrogate marker for skeletal muscle mass and sarcopenia, which further indicates frailty and predicts overall survival (OS). The aim of this study was to determine its usefulness as a prognostic marker in patients with high-grade glioma compared to functional status scales.MethodsTMT was measured in preoperative axial T1-weighted contrast-enhanced magnetic resonance images in 277 patients who received surgical treatment of newly diagnosed WHO III and IV gliomas in our institution between 2015 and 2020. Clinical Frailty Scale (CFS) and Karnofsky Performance Scale (KPS) were assessed preoperatively and during a follow-up visit.ResultsFemale gender has shown significant correlation with TMT, while TMT did not correlate with preoperative and follow-up functional scores, age, WHO classification, IDH mutation, MGMT promoter methylation, EGFR and ATRX expression, or 1p/19q co-deletion. No significant prognostic value of TMT could be shown in 6, 12, and 24 months OS, while changes in CFS and KPS proved to have a significant impact.ConclusionOnly female gender, but no other clinical, histological, or molecular marker showed any interrelation with TMT. Functional scores outclass measuring TMT as a reliable prognostic factor for predicting OS in patients with high-grade glioma.https://www.frontiersin.org/articles/10.3389/fonc.2023.1237105/fullfrailtytemporal muscle thicknessGBMCFSsurvival |
| spellingShingle | Julia Klingenschmid Aleksandrs Krigers Victoria Schön Daniel Pinggera Johannes Kerschbaumer Astrid E. Grams Claudius Thomé Christian F. Freyschlag Temporal muscle thickness has no prognostic relevance in patients with high-grade glioma compared to functional scales Frontiers in Oncology frailty temporal muscle thickness GBM CFS survival |
| title | Temporal muscle thickness has no prognostic relevance in patients with high-grade glioma compared to functional scales |
| title_full | Temporal muscle thickness has no prognostic relevance in patients with high-grade glioma compared to functional scales |
| title_fullStr | Temporal muscle thickness has no prognostic relevance in patients with high-grade glioma compared to functional scales |
| title_full_unstemmed | Temporal muscle thickness has no prognostic relevance in patients with high-grade glioma compared to functional scales |
| title_short | Temporal muscle thickness has no prognostic relevance in patients with high-grade glioma compared to functional scales |
| title_sort | temporal muscle thickness has no prognostic relevance in patients with high grade glioma compared to functional scales |
| topic | frailty temporal muscle thickness GBM CFS survival |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1237105/full |
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