DARDN: A Deep-Learning Approach for CTCF Binding Sequence Classification and Oncogenic Regulatory Feature Discovery

DARDN: A Deep-Learning Approach for CTCF Binding Sequence Classification and Oncogenic Regulatory Feature Discovery

Characterization of gene regulatory mechanisms in cancer is a key task in cancer genomics. CCCTC-binding factor (CTCF), a DNA binding protein, exhibits specific binding patterns in the genome of cancer cells and has a non-canonical function to facilitate oncogenic transcription programs by cooperati...

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Bibliographic Details
Main Authors: Hyun Jae Cho, Zhenjia Wang, Yidan Cong, Stefan Bekiranov, Aidong Zhang, Chongzhi Zang
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Genes
Subjects:
CTCF
machine learning
DARDN
DeepLIFT
Online Access:https://www.mdpi.com/2073-4425/15/2/144

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