<i>Myristica fragrans</i> Kernels Prevent Paracetamol-Induced Hepatotoxicity by Inducing Anti-Apoptotic Genes and Nrf2/HO-1 Pathway

<i>Myristica fragrans</i> Kernels Prevent Paracetamol-Induced Hepatotoxicity by Inducing Anti-Apoptotic Genes and Nrf2/HO-1 Pathway

Paracetamol is responsible for acute liver failure in humans and experimental animals when taken at high doses and transformed into a reactive metabolite by the liver cytochrome P450. On the other hand, nutmeg is rich with many phytochemical ingredients that are known for their ability to inhibit cy...

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Bibliographic Details
Main Authors: Mohamed A. Dkhil, Ahmed E. Abdel Moneim, Taghreed A. Hafez, Murad A. Mubaraki, Walid F. Mohamed, Felwa A. Thagfan, Saleh Al-Quraishy
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:International Journal of Molecular Sciences
Subjects:
paracetamol
<i>Myristica fragrans</i> kernels
heme oxygenase 1
liver
Online Access:https://www.mdpi.com/1422-0067/20/4/993

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