The Role of Bone Morphogenetic Protein Receptor Type 2 (<i>BMPR2</i>) and the Prospects of Utilizing Induced Pluripotent Stem Cells (iPSCs) in Pulmonary Arterial Hypertension Disease Modeling

The Role of Bone Morphogenetic Protein Receptor Type 2 (<i>BMPR2</i>) and the Prospects of Utilizing Induced Pluripotent Stem Cells (iPSCs) in Pulmonary Arterial Hypertension Disease Modeling

Pulmonary arterial hypertension (PAH) is a progressive disease characterized by increased pulmonary vascular resistance (PVR), causing right ventricular hypertrophy and ultimately death from right heart failure. Heterozygous mutations in the bone morphogenetic protein receptor type 2 (<i>BMPR2...

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Bibliographic Details
Main Authors: Anichavezhi Devendran, Sumanta Kar, Rasheed Bailey, Maria Giovanna Trivieri
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
pulmonary arterial hypertension
pulmonary vascular resistance
vascular remodeling
induced pluripotent stem cell
disease modeling
pulmonary arterial endothelial cells
Online Access:https://www.mdpi.com/2073-4409/11/23/3823

Internet

https://www.mdpi.com/2073-4409/11/23/3823

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