A Case of a Beta-Human Chorionic Gonadotropin Secreting Sinonasal Teratocarcinosarcoma
Abstract Background and Importance Sinonasal teratocarcinosarcoma (SNTCS) is an unusual and aggressive neoplasm characterized by the combination of teratoma and carcinosarcoma features that is often misdiagnosed based on a biopsy sample. Approximately 60 cases have been reported in the...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Georg Thieme Verlag KG
2014-05-01
|
| Series: | Journal of Neurological Surgery Reports |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0034-1373667 |
| _version_ | 1811327308402786304 |
|---|---|
| author | Benjamin D. Weinberg Kathy L. Newell Fen Wang |
| author_facet | Benjamin D. Weinberg Kathy L. Newell Fen Wang |
| author_sort | Benjamin D. Weinberg |
| collection | DOAJ |
| description | Abstract
Background and Importance Sinonasal teratocarcinosarcoma (SNTCS) is an unusual and aggressive neoplasm characterized by the combination of teratoma and carcinosarcoma features that is often misdiagnosed based on a biopsy sample. Approximately 60 cases have been reported in the English literature, but none have been associated with serum tumor markers. We report a case of SNTCS with elevation of serum β-human chorionic gonadotropin (hCG) level.
Clinical Presentation The patient was a 22-year-old pregnant woman at diagnosis, and her β-hCG level was appropriately elevated. Her initial treatment was a surgical resection followed by radiation therapy (RT). Two years later, the patient had a pregnancy work-up after a sexual assault. Her serum β-hCG was elevated, but a nongravid uterus was seen on ultrasound. Magnetic resonance imaging (MRI) of the head revealed an intracranial tumor recurrence in the right frontal lobe. During salvage RT, β-hCG decreased rapidly to normal levels, with a complete tumor response on MRI. Retrospective examination of the initial surgical specimen showed expression of β-hCG associated with the anaplastic mesenchymal component.
Conclusion This is the first reported case of a β-hCG secreting SNTCS. The source of β-hCG production was traced to a neoplastic smooth muscle component of the tumor. |
| first_indexed | 2024-04-13T15:04:21Z |
| format | Article |
| id | doaj.art-62d3a33dc9874a718a841fcbf5489daf |
| institution | Directory Open Access Journal |
| issn | 2193-6358 2193-6366 |
| language | English |
| last_indexed | 2024-04-13T15:04:21Z |
| publishDate | 2014-05-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | Journal of Neurological Surgery Reports |
| spelling | doaj.art-62d3a33dc9874a718a841fcbf5489daf2022-12-22T02:42:12ZengGeorg Thieme Verlag KGJournal of Neurological Surgery Reports2193-63582193-63662014-05-017501e103e10710.1055/s-0034-1373667A Case of a Beta-Human Chorionic Gonadotropin Secreting Sinonasal TeratocarcinosarcomaBenjamin D. Weinberg0Kathy L. Newell1Fen Wang2Department of Radiation Oncology, Wayne State University, Detroit, Michigan, United StatesDepartment of Pathology, University of Kansas Medical Center, Kansas City, Kansas, United StatesDepartment of Radiation Oncology, University of Kansas Medical Center, Kansas City, Kansas, United StatesAbstract Background and Importance Sinonasal teratocarcinosarcoma (SNTCS) is an unusual and aggressive neoplasm characterized by the combination of teratoma and carcinosarcoma features that is often misdiagnosed based on a biopsy sample. Approximately 60 cases have been reported in the English literature, but none have been associated with serum tumor markers. We report a case of SNTCS with elevation of serum β-human chorionic gonadotropin (hCG) level. Clinical Presentation The patient was a 22-year-old pregnant woman at diagnosis, and her β-hCG level was appropriately elevated. Her initial treatment was a surgical resection followed by radiation therapy (RT). Two years later, the patient had a pregnancy work-up after a sexual assault. Her serum β-hCG was elevated, but a nongravid uterus was seen on ultrasound. Magnetic resonance imaging (MRI) of the head revealed an intracranial tumor recurrence in the right frontal lobe. During salvage RT, β-hCG decreased rapidly to normal levels, with a complete tumor response on MRI. Retrospective examination of the initial surgical specimen showed expression of β-hCG associated with the anaplastic mesenchymal component. Conclusion This is the first reported case of a β-hCG secreting SNTCS. The source of β-hCG production was traced to a neoplastic smooth muscle component of the tumor.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0034-1373667teratocarcinosarcomaβ-hcggonadotropinserumintracranial |
| spellingShingle | Benjamin D. Weinberg Kathy L. Newell Fen Wang A Case of a Beta-Human Chorionic Gonadotropin Secreting Sinonasal Teratocarcinosarcoma Journal of Neurological Surgery Reports teratocarcinosarcoma β-hcg gonadotropin serum intracranial |
| title | A Case of a Beta-Human Chorionic Gonadotropin Secreting Sinonasal Teratocarcinosarcoma |
| title_full | A Case of a Beta-Human Chorionic Gonadotropin Secreting Sinonasal Teratocarcinosarcoma |
| title_fullStr | A Case of a Beta-Human Chorionic Gonadotropin Secreting Sinonasal Teratocarcinosarcoma |
| title_full_unstemmed | A Case of a Beta-Human Chorionic Gonadotropin Secreting Sinonasal Teratocarcinosarcoma |
| title_short | A Case of a Beta-Human Chorionic Gonadotropin Secreting Sinonasal Teratocarcinosarcoma |
| title_sort | case of a beta human chorionic gonadotropin secreting sinonasal teratocarcinosarcoma |
| topic | teratocarcinosarcoma β-hcg gonadotropin serum intracranial |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0034-1373667 |
| work_keys_str_mv | AT benjamindweinberg acaseofabetahumanchorionicgonadotropinsecretingsinonasalteratocarcinosarcoma AT kathylnewell acaseofabetahumanchorionicgonadotropinsecretingsinonasalteratocarcinosarcoma AT fenwang acaseofabetahumanchorionicgonadotropinsecretingsinonasalteratocarcinosarcoma AT benjamindweinberg caseofabetahumanchorionicgonadotropinsecretingsinonasalteratocarcinosarcoma AT kathylnewell caseofabetahumanchorionicgonadotropinsecretingsinonasalteratocarcinosarcoma AT fenwang caseofabetahumanchorionicgonadotropinsecretingsinonasalteratocarcinosarcoma |