Intranasal melanoma treated with radiation therapy in three dogs
Three dogs were investigated for chronic unilateral nasal discharge. In all cases CT imaging showed an intranasal mass causing turbinate lysis and no evidence of metastasis. Cytology in cases 1 (a 14-year-old neutered male crossbreed dog) and 2 (a five-year-old neutered male German Shepherd dog) dem...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-01-01
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| Series: | Veterinary Quarterly |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/01652176.2017.1387828 |
| _version_ | 1818836408791465984 |
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| author | Owen Davies Sarah Spencer Slavomira Necova Emma Holmes Angela Taylor Laura Blackwood Ana Lara-Garcia |
| author_facet | Owen Davies Sarah Spencer Slavomira Necova Emma Holmes Angela Taylor Laura Blackwood Ana Lara-Garcia |
| author_sort | Owen Davies |
| collection | DOAJ |
| description | Three dogs were investigated for chronic unilateral nasal discharge. In all cases CT imaging showed an intranasal mass causing turbinate lysis and no evidence of metastasis. Cytology in cases 1 (a 14-year-old neutered male crossbreed dog) and 2 (a five-year-old neutered male German Shepherd dog) demonstrated a pleomorphic cell population with variable intracellular pigment suspicious of melanocytic neoplasia. Histopathology with immunohistochemistry (Melan-A and vimentin, plus PNL-2 in one case) confirmed the diagnosis of melanoma in all dogs. All dogs were treated with megavoltage radiotherapy using linear accelerators. Cases 1 and 3 (a nine-year-old neutered female beagle dog) received a hypofractionated (4 × 8 Gy) protocol and case 2 received a definitive (12 × 4 Gy) protocol. Complete remission was demonstrated on repeat CT scan five months after diagnosis in case 1 and seven months in case 2. Stable disease was documented on CT at four months for case 3; however, clinical signs in this dog remained controlled for 10 months in total. Case 1 died of unrelated causes five months after diagnosis, case 2 was euthanased due to the development of seizures 13 months after diagnosis, and case 3 was lost to follow-up 12 months after diagnosis. Melanoma should be considered as a rare differential diagnosis for primary nasal neoplasia in the dog and radiation therapy can be used as effective local therapy. |
| first_indexed | 2024-12-19T03:06:08Z |
| format | Article |
| id | doaj.art-62d648443eb148dbbf2c250e227f886d |
| institution | Directory Open Access Journal |
| issn | 0165-2176 1875-5941 |
| language | English |
| last_indexed | 2024-12-19T03:06:08Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Veterinary Quarterly |
| spelling | doaj.art-62d648443eb148dbbf2c250e227f886d2022-12-21T20:38:06ZengTaylor & Francis GroupVeterinary Quarterly0165-21761875-59412017-01-0137127428110.1080/01652176.2017.13878281387828Intranasal melanoma treated with radiation therapy in three dogsOwen Davies0Sarah Spencer1Slavomira Necova2Emma Holmes3Angela Taylor4Laura Blackwood5Ana Lara-Garcia6University of LondonUniversity of BristolVRCCUniversity of LondonUniversity of LondonUniversity of Liverpool, Leahurst CampusUniversity of LondonThree dogs were investigated for chronic unilateral nasal discharge. In all cases CT imaging showed an intranasal mass causing turbinate lysis and no evidence of metastasis. Cytology in cases 1 (a 14-year-old neutered male crossbreed dog) and 2 (a five-year-old neutered male German Shepherd dog) demonstrated a pleomorphic cell population with variable intracellular pigment suspicious of melanocytic neoplasia. Histopathology with immunohistochemistry (Melan-A and vimentin, plus PNL-2 in one case) confirmed the diagnosis of melanoma in all dogs. All dogs were treated with megavoltage radiotherapy using linear accelerators. Cases 1 and 3 (a nine-year-old neutered female beagle dog) received a hypofractionated (4 × 8 Gy) protocol and case 2 received a definitive (12 × 4 Gy) protocol. Complete remission was demonstrated on repeat CT scan five months after diagnosis in case 1 and seven months in case 2. Stable disease was documented on CT at four months for case 3; however, clinical signs in this dog remained controlled for 10 months in total. Case 1 died of unrelated causes five months after diagnosis, case 2 was euthanased due to the development of seizures 13 months after diagnosis, and case 3 was lost to follow-up 12 months after diagnosis. Melanoma should be considered as a rare differential diagnosis for primary nasal neoplasia in the dog and radiation therapy can be used as effective local therapy.http://dx.doi.org/10.1080/01652176.2017.1387828Dogcaninenasalcancermelanomaradiotherapy |
| spellingShingle | Owen Davies Sarah Spencer Slavomira Necova Emma Holmes Angela Taylor Laura Blackwood Ana Lara-Garcia Intranasal melanoma treated with radiation therapy in three dogs Veterinary Quarterly Dog canine nasal cancer melanoma radiotherapy |
| title | Intranasal melanoma treated with radiation therapy in three dogs |
| title_full | Intranasal melanoma treated with radiation therapy in three dogs |
| title_fullStr | Intranasal melanoma treated with radiation therapy in three dogs |
| title_full_unstemmed | Intranasal melanoma treated with radiation therapy in three dogs |
| title_short | Intranasal melanoma treated with radiation therapy in three dogs |
| title_sort | intranasal melanoma treated with radiation therapy in three dogs |
| topic | Dog canine nasal cancer melanoma radiotherapy |
| url | http://dx.doi.org/10.1080/01652176.2017.1387828 |
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