Alpha-Adrenergic Mechanisms in the Cardiovascular Hyperreactivity to Norepinephrine-Infusion in Essential Hypertension
AimsEssential hypertension (EHT) is characterized by cardiovascular hyperreactivity to stress but underlying mechanism are not fully understood. Here, we investigated the role of α-adrenergic receptors (α-AR) in the cardiovascular reactivity to a norepinephrine (NE)-stress reactivity-mimicking NE-in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.824616/full |
| _version_ | 1828400251767095296 |
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| author | Lisa-Marie Walther Lisa-Marie Walther Roland von Känel Nadja Heimgartner Claudia Zuccarella-Hackl Guido Stirnimann Petra H. Wirtz Petra H. Wirtz |
| author_facet | Lisa-Marie Walther Lisa-Marie Walther Roland von Känel Nadja Heimgartner Claudia Zuccarella-Hackl Guido Stirnimann Petra H. Wirtz Petra H. Wirtz |
| author_sort | Lisa-Marie Walther |
| collection | DOAJ |
| description | AimsEssential hypertension (EHT) is characterized by cardiovascular hyperreactivity to stress but underlying mechanism are not fully understood. Here, we investigated the role of α-adrenergic receptors (α-AR) in the cardiovascular reactivity to a norepinephrine (NE)-stress reactivity-mimicking NE-infusion in essential hypertensive individuals (HT) as compared to normotensive individuals (NT).Methods24 male HT and 24 male NT participated in three experimental trials on three separate days with a 1-min infusion followed by a 15-min infusion. Trials varied in infusion-substances: placebo saline (Sal)-infusions (trial-1:Sal+Sal), NE-infusion without (trial-2:Sal+NE) or with non-selective α-AR blockade by phentolamine (PHE) (trial-3:PHE+NE). NE-infusion dosage (5µg/ml/min) and duration were chosen to mimic duration and physiological effects of NE-release in reaction to established stress induction protocols. We repeatedly measured systolic (SBP) and diastolic blood pressure (DBP) as well as heart rate before, during, and after infusions.ResultsSBP and DBP reactivity to the three infusion-trials differed between HT and NT (p’s≤.014). HT exhibited greater BP reactivity to NE-infusion alone compared to NT (trial-2-vs-trial-1: p’s≤.033). Group differences in DBP reactivity to NE disappeared with prior PHE blockade (trial-3: p=.26), while SBP reactivity differences remained (trial-3: p=.016). Heart rate reactivity to infusion-trials did not differ between HT and NT (p=.73).ConclusionOur findings suggest a mediating role of α-AR in DBP hyperreactivity to NE-infusion in EHT. However, in SBP hyperreactivity to NE-infusion in EHT, the functioning of α-AR seems impaired suggesting that the SBP hyperreactivity in hypertension is not mediated by α-AR. |
| first_indexed | 2024-12-10T09:28:44Z |
| format | Article |
| id | doaj.art-62d8d120823549e7908de278ebe3404a |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-10T09:28:44Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-62d8d120823549e7908de278ebe3404a2022-12-22T01:54:25ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-07-011310.3389/fendo.2022.824616824616Alpha-Adrenergic Mechanisms in the Cardiovascular Hyperreactivity to Norepinephrine-Infusion in Essential HypertensionLisa-Marie Walther0Lisa-Marie Walther1Roland von Känel2Nadja Heimgartner3Claudia Zuccarella-Hackl4Guido Stirnimann5Petra H. Wirtz6Petra H. Wirtz7Biological Work and Health Psychology, University of Konstanz, Konstanz, GermanyCentre for the Advanced Study of Collective Behaviour, University of Konstanz, Konstanz, GermanyDepartment of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Zurich, SwitzerlandDivision of Clinical Psychology and Psychotherapy, University of Basel, Basel, SwitzerlandDepartment of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Zurich, SwitzerlandDepartment of Visceral Surgery and Medicine, University Hospital Inselspital and University of Bern, Bern, SwitzerlandBiological Work and Health Psychology, University of Konstanz, Konstanz, GermanyCentre for the Advanced Study of Collective Behaviour, University of Konstanz, Konstanz, GermanyAimsEssential hypertension (EHT) is characterized by cardiovascular hyperreactivity to stress but underlying mechanism are not fully understood. Here, we investigated the role of α-adrenergic receptors (α-AR) in the cardiovascular reactivity to a norepinephrine (NE)-stress reactivity-mimicking NE-infusion in essential hypertensive individuals (HT) as compared to normotensive individuals (NT).Methods24 male HT and 24 male NT participated in three experimental trials on three separate days with a 1-min infusion followed by a 15-min infusion. Trials varied in infusion-substances: placebo saline (Sal)-infusions (trial-1:Sal+Sal), NE-infusion without (trial-2:Sal+NE) or with non-selective α-AR blockade by phentolamine (PHE) (trial-3:PHE+NE). NE-infusion dosage (5µg/ml/min) and duration were chosen to mimic duration and physiological effects of NE-release in reaction to established stress induction protocols. We repeatedly measured systolic (SBP) and diastolic blood pressure (DBP) as well as heart rate before, during, and after infusions.ResultsSBP and DBP reactivity to the three infusion-trials differed between HT and NT (p’s≤.014). HT exhibited greater BP reactivity to NE-infusion alone compared to NT (trial-2-vs-trial-1: p’s≤.033). Group differences in DBP reactivity to NE disappeared with prior PHE blockade (trial-3: p=.26), while SBP reactivity differences remained (trial-3: p=.016). Heart rate reactivity to infusion-trials did not differ between HT and NT (p=.73).ConclusionOur findings suggest a mediating role of α-AR in DBP hyperreactivity to NE-infusion in EHT. However, in SBP hyperreactivity to NE-infusion in EHT, the functioning of α-AR seems impaired suggesting that the SBP hyperreactivity in hypertension is not mediated by α-AR.https://www.frontiersin.org/articles/10.3389/fendo.2022.824616/fullessential hypertensionnorepinephrine-infusionalpha-adrenergic receptor blockadephentolaminecardiovascular reactivity |
| spellingShingle | Lisa-Marie Walther Lisa-Marie Walther Roland von Känel Nadja Heimgartner Claudia Zuccarella-Hackl Guido Stirnimann Petra H. Wirtz Petra H. Wirtz Alpha-Adrenergic Mechanisms in the Cardiovascular Hyperreactivity to Norepinephrine-Infusion in Essential Hypertension Frontiers in Endocrinology essential hypertension norepinephrine-infusion alpha-adrenergic receptor blockade phentolamine cardiovascular reactivity |
| title | Alpha-Adrenergic Mechanisms in the Cardiovascular Hyperreactivity to Norepinephrine-Infusion in Essential Hypertension |
| title_full | Alpha-Adrenergic Mechanisms in the Cardiovascular Hyperreactivity to Norepinephrine-Infusion in Essential Hypertension |
| title_fullStr | Alpha-Adrenergic Mechanisms in the Cardiovascular Hyperreactivity to Norepinephrine-Infusion in Essential Hypertension |
| title_full_unstemmed | Alpha-Adrenergic Mechanisms in the Cardiovascular Hyperreactivity to Norepinephrine-Infusion in Essential Hypertension |
| title_short | Alpha-Adrenergic Mechanisms in the Cardiovascular Hyperreactivity to Norepinephrine-Infusion in Essential Hypertension |
| title_sort | alpha adrenergic mechanisms in the cardiovascular hyperreactivity to norepinephrine infusion in essential hypertension |
| topic | essential hypertension norepinephrine-infusion alpha-adrenergic receptor blockade phentolamine cardiovascular reactivity |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.824616/full |
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