Vesicle Docking Is a Key Target of Local PI(4,5)P2 Metabolism in the Secretory Pathway of INS-1 Cells

Vesicle Docking Is a Key Target of Local PI(4,5)P2 Metabolism in the Secretory Pathway of INS-1 Cells

Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) signaling is transient and spatially confined in live cells. How this pattern of signaling regulates transmitter release and hormone secretion has not been addressed. We devised an optogenetic approach to control PI(4,5)P2 levels in time and space in...

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Bibliographic Details
Main Authors: Chen Ji, Fan Fan, Xuelin Lou
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
optogenetics
insulin secretion
PI(4,5)P2 lipid signaling
dense core vesicles
docking
exocytosis
Ca2+ signal
TIRFM
live-cell imaging
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717310070

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