STUDIU DE SPECTROSCOPIE ÎN INFRAROŞU AL UNOR PRODUSE TERNARE DE SUBSTANŢE ANTIVIRALE DIN GRUPA AMANTADINELOR CU CICLODEXTRINE
Rimantadine hydrochloride (rimantadine) and amantadine hydrochloride (amantadine) are synthetic antiviral drugs, inhibitors of M2 membrane protein ion channel of the influenza A virus. Both amantadine and rimantadine are slowly absorbed after the oral administration and induce significant gastroint...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Moldova State University
2008-12-01
|
| Series: | Studia Universitatis Moldaviae: Stiinte reale si ale naturii |
| Online Access: | https://ojs.studiamsu.md/index.php/stiinte_reale_naturii/article/view/370 |
| _version_ | 1811187650140307456 |
|---|---|
| author | USM ADMIN |
| author_facet | USM ADMIN |
| author_sort | USM ADMIN |
| collection | DOAJ |
| description |
Rimantadine hydrochloride (rimantadine) and amantadine hydrochloride (amantadine) are synthetic antiviral drugs, inhibitors of M2 membrane protein ion channel of the influenza A virus. Both amantadine and rimantadine are slowly absorbed after the oral administration and induce significant gastrointestinal adverse effects. In order to reduce the side effects and to improve pharmacokinetics of the studied drugs, cyclodextrin complexation has been proposed. This study is dedicated to characterization, by means of infrared spectrometry, of amantadine and rimantadine products with β- cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HPβCD) at the presence of a hydrosoluble polymer - polyvinylpyrrolidone (PVP). The corresponding ternary products were obtained using two main methods: kneading and coevaporation. In the result of this study we concluded that, as well as in the spectra of binary products studied before, the stretching vibrations of cyclodextrin glycosidic bonds and hydroxyl groups have significantly changed their frequencies in the spectra of AM-βCD-PVP and RIM-βCD-PVP products. At the same time these vibrations retained their frequencies unchanged in the spectra of AM-HPβCD-PVP and RIM-HPβCD-PVP products. Supposedly, the inclusion complex formation took place in the case of βCD-containing products, while the HPβCD-containing products remained uncomplexed.
|
| first_indexed | 2024-04-11T14:06:56Z |
| format | Article |
| id | doaj.art-62dbdd8b4357423696c9f54d213a1dee |
| institution | Directory Open Access Journal |
| issn | 1814-3237 1857-498X |
| language | English |
| last_indexed | 2024-04-11T14:06:56Z |
| publishDate | 2008-12-01 |
| publisher | Moldova State University |
| record_format | Article |
| series | Studia Universitatis Moldaviae: Stiinte reale si ale naturii |
| spelling | doaj.art-62dbdd8b4357423696c9f54d213a1dee2022-12-22T04:19:52ZengMoldova State UniversityStudia Universitatis Moldaviae: Stiinte reale si ale naturii1814-32371857-498X2008-12-017STUDIU DE SPECTROSCOPIE ÎN INFRAROŞU AL UNOR PRODUSE TERNARE DE SUBSTANŢE ANTIVIRALE DIN GRUPA AMANTADINELOR CU CICLODEXTRINEUSM ADMIN0Studia Universitas Moldaviae Rimantadine hydrochloride (rimantadine) and amantadine hydrochloride (amantadine) are synthetic antiviral drugs, inhibitors of M2 membrane protein ion channel of the influenza A virus. Both amantadine and rimantadine are slowly absorbed after the oral administration and induce significant gastrointestinal adverse effects. In order to reduce the side effects and to improve pharmacokinetics of the studied drugs, cyclodextrin complexation has been proposed. This study is dedicated to characterization, by means of infrared spectrometry, of amantadine and rimantadine products with β- cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HPβCD) at the presence of a hydrosoluble polymer - polyvinylpyrrolidone (PVP). The corresponding ternary products were obtained using two main methods: kneading and coevaporation. In the result of this study we concluded that, as well as in the spectra of binary products studied before, the stretching vibrations of cyclodextrin glycosidic bonds and hydroxyl groups have significantly changed their frequencies in the spectra of AM-βCD-PVP and RIM-βCD-PVP products. At the same time these vibrations retained their frequencies unchanged in the spectra of AM-HPβCD-PVP and RIM-HPβCD-PVP products. Supposedly, the inclusion complex formation took place in the case of βCD-containing products, while the HPβCD-containing products remained uncomplexed. https://ojs.studiamsu.md/index.php/stiinte_reale_naturii/article/view/370 |
| spellingShingle | USM ADMIN STUDIU DE SPECTROSCOPIE ÎN INFRAROŞU AL UNOR PRODUSE TERNARE DE SUBSTANŢE ANTIVIRALE DIN GRUPA AMANTADINELOR CU CICLODEXTRINE Studia Universitatis Moldaviae: Stiinte reale si ale naturii |
| title | STUDIU DE SPECTROSCOPIE ÎN INFRAROŞU AL UNOR PRODUSE TERNARE DE SUBSTANŢE ANTIVIRALE DIN GRUPA AMANTADINELOR CU CICLODEXTRINE |
| title_full | STUDIU DE SPECTROSCOPIE ÎN INFRAROŞU AL UNOR PRODUSE TERNARE DE SUBSTANŢE ANTIVIRALE DIN GRUPA AMANTADINELOR CU CICLODEXTRINE |
| title_fullStr | STUDIU DE SPECTROSCOPIE ÎN INFRAROŞU AL UNOR PRODUSE TERNARE DE SUBSTANŢE ANTIVIRALE DIN GRUPA AMANTADINELOR CU CICLODEXTRINE |
| title_full_unstemmed | STUDIU DE SPECTROSCOPIE ÎN INFRAROŞU AL UNOR PRODUSE TERNARE DE SUBSTANŢE ANTIVIRALE DIN GRUPA AMANTADINELOR CU CICLODEXTRINE |
| title_short | STUDIU DE SPECTROSCOPIE ÎN INFRAROŞU AL UNOR PRODUSE TERNARE DE SUBSTANŢE ANTIVIRALE DIN GRUPA AMANTADINELOR CU CICLODEXTRINE |
| title_sort | studiu de spectroscopie in infrarosu al unor produse ternare de substante antivirale din grupa amantadinelor cu ciclodextrine |
| url | https://ojs.studiamsu.md/index.php/stiinte_reale_naturii/article/view/370 |
| work_keys_str_mv | AT usmadmin studiudespectroscopieininfrarosualunorproduseternaredesubstanteantiviraledingrupaamantadinelorcuciclodextrine |